Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity

Maureen S. Williams, Mary Burk, Charles L. Loprinzi, Mary Hill, Paula J. Schomberg, Kim Nearhood, Judith R. O'Fallon, John A. Laurie, Thomas G. Shanahan, Randy L. Moore, Rodolfo E. Urias, Robert R. Kuske, Roland E. Engel, William D. Eggleston

Research output: Contribution to journalArticlepeer-review

194 Scopus citations

Abstract

Purpose: Considerable pilot data and clinical experience suggested that an aloe vera gel might help to prevent radiation therapy-induced dermatitis. Methods and Materials: Two Phase III randomized trials were conducted. The first one was double blinded, utilized a placebo gel, and involved 194 women receiving breast or chest wall irradiation. The second trial randomized 108 such patients to aloe vera gel vs. no treatment. Skin dermatitis was scored weekly during both trials both by patients and by health care providers. Results: Skin dermatitis scores were virtually identical on both treatment arms during both of the trials. The only toxicity from the gel was rare contact dermatitis. Conclusions: This dose and schedule of an aloe vera gel does not protect against radiation therapy-induced dermatitis.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalInternational Journal of Radiation Oncology Biology Physics
Volume36
Issue number2
DOIs
StatePublished - Sep 1 1996

Keywords

  • Aloe vera gel
  • Radiation-induced dermatitis

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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