@article{124eba42c0c6475aa7973b3edc33a208,
title = "Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity",
abstract = "Purpose: Considerable pilot data and clinical experience suggested that an aloe vera gel might help to prevent radiation therapy-induced dermatitis. Methods and Materials: Two Phase III randomized trials were conducted. The first one was double blinded, utilized a placebo gel, and involved 194 women receiving breast or chest wall irradiation. The second trial randomized 108 such patients to aloe vera gel vs. no treatment. Skin dermatitis was scored weekly during both trials both by patients and by health care providers. Results: Skin dermatitis scores were virtually identical on both treatment arms during both of the trials. The only toxicity from the gel was rare contact dermatitis. Conclusions: This dose and schedule of an aloe vera gel does not protect against radiation therapy-induced dermatitis.",
keywords = "Aloe vera gel, Radiation-induced dermatitis",
author = "Williams, {Maureen S.} and Mary Burk and Loprinzi, {Charles L.} and Mary Hill and Schomberg, {Paula J.} and Kim Nearhood and O'Fallon, {Judith R.} and Laurie, {John A.} and Shanahan, {Thomas G.} and Moore, {Randy L.} and Urias, {Rodolfo E.} and Kuske, {Robert R.} and Engel, {Roland E.} and Eggleston, {William D.}",
note = "Funding Information: There are no well-established prophylactic skin treatment measures to prevent radiation skin toxicity, although it is generally recommended that the skin in the irradiated Reprint requests to: Charles L. Loprinzi, M.D., Mayo Clinic, 200 First Street SW, Rochester, MN 55905. Acknowledgements-This study was conducted as a collaborative trial of North Central Cancer Treatment Group and Mayo Clinic and was supported in part by Public Health Service Grants CA-25224, CA-37404, CA-15083, CA-35415, CA-35195, CA-35269, CA-35101, CA-37417, CA-35272, CA-52352, CA-35448, CA-35103, and CA-351 13 from the National Cancer Institute, Department of Health and Human Services. Additional participating institutions include: Saskatchewan Cancer Foundation, Allan Blair Cancer Centre, Regina, Saskatchewan CANADA S4T 7Tl (Michael A. Poon, M.B., B.S.); Quain and Ramstad Clinic, Bismarck. ND 58506 (Delano M. Pfeifle, M.D.): Cedar Rapids On-",
year = "1996",
month = sep,
day = "1",
doi = "10.1016/S0360-3016(96)00320-3",
language = "English (US)",
volume = "36",
pages = "345--349",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "2",
}