Pharmacokinetics of bendamustine in the central nervous system: Chemoinformatic screening followed by validation in a murine model

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4 Scopus citations

Abstract

Bendamustine is a novel bifunctional chemotherapeutic agent with activity against multiple cancers. There has been no definitive data on its capacity to penetrate the central nervous system. Our chemoinformatic screening predicted excellent CNS penetration, which was validated by in vivo pharmacokinetic analysis in mice. Bendamustine has 35% CNS penetration in our mouse model. Bendamustine should be further evaluated for use in treatment of primary and secondary CNS tumors.

Original languageEnglish (US)
Pages (from-to)1526-1530
Number of pages5
JournalMedChemComm
Volume3
Issue number12
DOIs
StatePublished - Dec 1 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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