Pharmacokinetics of bendamustine in the central nervous system: Chemoinformatic screening followed by validation in a murine model

Zhimin Li; Thomas Caulfield; Yushi Qiu; John A. Copland; Han W. Tun

doi:10.1039/c2md20233f

Pharmacokinetics of bendamustine in the central nervous system: Chemoinformatic screening followed by validation in a murine model

Zhimin Li, Thomas Caulfield, Yushi Qiu, John A. Copland, Han W. Tun

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Bendamustine is a novel bifunctional chemotherapeutic agent with activity against multiple cancers. There has been no definitive data on its capacity to penetrate the central nervous system. Our chemoinformatic screening predicted excellent CNS penetration, which was validated by in vivo pharmacokinetic analysis in mice. Bendamustine has 35% CNS penetration in our mouse model. Bendamustine should be further evaluated for use in treatment of primary and secondary CNS tumors.

Original language	English (US)
Pages (from-to)	1526-1530
Number of pages	5
Journal	MedChemComm
Volume	3
Issue number	12
DOIs	https://doi.org/10.1039/c2md20233f
State	Published - Dec 2012

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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abstract = "Bendamustine is a novel bifunctional chemotherapeutic agent with activity against multiple cancers. There has been no definitive data on its capacity to penetrate the central nervous system. Our chemoinformatic screening predicted excellent CNS penetration, which was validated by in vivo pharmacokinetic analysis in mice. Bendamustine has 35% CNS penetration in our mouse model. Bendamustine should be further evaluated for use in treatment of primary and secondary CNS tumors.",

author = "Zhimin Li and Thomas Caulfield and Yushi Qiu and Copland, {John A.} and Tun, {Han W.}",

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AU - Li, Zhimin

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AU - Qiu, Yushi

AU - Copland, John A.

AU - Tun, Han W.

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Pharmacokinetics of bendamustine in the central nervous system: Chemoinformatic screening followed by validation in a murine model

Abstract

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