Pharmacogenomics: Candidate gene identification, functional validation and mechanisms

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48 Citations (Scopus)

Abstract

Pharmacogenetics is the study of the role of inheritance in variation in drug response phenotypes. Those phenotypes can range from life-threatening adverse drugs reactions at one end of the spectrum to equally serious lack of therapeutic efficacy at the other. Over the past half century, pharmacogenetics has-like all of medical genetics-evolved from a discipline with a focus on monogenetic traits to become pharmacogenomics, with a genome-wide perspective. This article will briefly review recent examples of the application of genome-wide techniques to clinical pharmacogenomic studies and to pharmacogenomic model systems that vary from cell line-based model systems to yeast gene deletion libraries. Functional validation of candidate genes and the use of genome-wide techniques to gain mechanistic insights will be emphasized for the establishment of biological plausibility and as essential follow-up steps after the identification of candidate genes.

Original languageEnglish (US)
JournalHuman Molecular Genetics
Volume17
Issue numberR2
DOIs
StatePublished - Oct 15 2008

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Pharmacogenetics
Genetic Association Studies
Genome
Phenotype
Gene Deletion
Medical Genetics
Drug-Related Side Effects and Adverse Reactions
Gene Library
Yeasts
Cell Line
Pharmaceutical Preparations
Genes
Pharmacogenomic Testing
Therapeutics

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

Cite this

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