Abstract
Pharmacogenetics is the study of the role of inheritance in variation in drug response phenotypes. Those phenotypes can range from life-threatening adverse drugs reactions at one end of the spectrum to equally serious lack of therapeutic efficacy at the other. Over the past half century, pharmacogenetics has-like all of medical genetics-evolved from a discipline with a focus on monogenetic traits to become pharmacogenomics, with a genome-wide perspective. This article will briefly review recent examples of the application of genome-wide techniques to clinical pharmacogenomic studies and to pharmacogenomic model systems that vary from cell line-based model systems to yeast gene deletion libraries. Functional validation of candidate genes and the use of genome-wide techniques to gain mechanistic insights will be emphasized for the establishment of biological plausibility and as essential follow-up steps after the identification of candidate genes.
Original language | English (US) |
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Pages (from-to) | R174-R179 |
Journal | Human molecular genetics |
Volume | 17 |
Issue number | R2 |
DOIs | |
State | Published - Oct 15 2008 |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Genetics(clinical)