@inproceedings{dfbcc0db9e6c4c7c98bd21ec54d8d673,
title = "Phantom-based MRI corrections and power to track brain change",
abstract = "The Alzheimer's Disease Neuroimaging Initiative (ADNI) employed phantom-based scaling of T1-weighted MP-RAGE brain images to improve spatial calibration of scans and longitudinal stability across study sites. Early in ADNI, errors in phantom based scaling were identified due to incorrect acquisition protocols or replacement of phantoms. Images initially made available with questionable scaling factors (scaled) were reprocessed (scaled-2) and made available to the scientific community. As many studies were conducted using images with sub-optimal scaling, we aimed to determine if the power to detect brain change differed between scaled and scaled-2 images. Using tensor-based morphometry, we found a high degree of correlation and no significant difference between scaled and scaled-2 images. We detected no significant differences between effect sizes derived from scaled and scaled-2 images. Our findings support the ADNI MRI core assessment that analyses carried out with either scaled or scaled-2 images may not offer a substantial difference in power.",
keywords = "Brain Modeling, Magnetic Resonance Imaging, Phantoms, Tensor-Based Morphometry",
author = "Ching, {Christopher R.K.} and Xue Hua and Chadwick Ward and Jeff Gunter and Bernstein, {Matt A.} and Jack, {Clifford R.} and Weiner, {Michael W.} and Thompson, {Paul M.}",
year = "2012",
doi = "10.1109/ISBI.2012.6235769",
language = "English (US)",
isbn = "9781457718588",
series = "Proceedings - International Symposium on Biomedical Imaging",
publisher = "IEEE Computer Society",
pages = "1172--1175",
booktitle = "2012 9th IEEE International Symposium on Biomedical Imaging",
note = "2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 ; Conference date: 02-05-2012 Through 05-05-2012",
}