Phantom-based MRI corrections and power to track brain change

Christopher R.K. Ching, Xue Hua, Chadwick Ward, Jeff Gunter, Matt A. Bernstein, Clifford R. Jack, Michael W. Weiner, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The Alzheimer's Disease Neuroimaging Initiative (ADNI) employed phantom-based scaling of T1-weighted MP-RAGE brain images to improve spatial calibration of scans and longitudinal stability across study sites. Early in ADNI, errors in phantom based scaling were identified due to incorrect acquisition protocols or replacement of phantoms. Images initially made available with questionable scaling factors (scaled) were reprocessed (scaled-2) and made available to the scientific community. As many studies were conducted using images with sub-optimal scaling, we aimed to determine if the power to detect brain change differed between scaled and scaled-2 images. Using tensor-based morphometry, we found a high degree of correlation and no significant difference between scaled and scaled-2 images. We detected no significant differences between effect sizes derived from scaled and scaled-2 images. Our findings support the ADNI MRI core assessment that analyses carried out with either scaled or scaled-2 images may not offer a substantial difference in power.

Original languageEnglish (US)
Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2012 - Proceedings
Pages1172-1175
Number of pages4
DOIs
StatePublished - Aug 15 2012
Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: May 2 2012May 5 2012

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
CountrySpain
CityBarcelona
Period5/2/125/5/12

Keywords

  • Brain Modeling
  • Magnetic Resonance Imaging
  • Phantoms
  • Tensor-Based Morphometry

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Phantom-based MRI corrections and power to track brain change'. Together they form a unique fingerprint.

  • Cite this

    Ching, C. R. K., Hua, X., Ward, C., Gunter, J., Bernstein, M. A., Jack, C. R., Weiner, M. W., & Thompson, P. M. (2012). Phantom-based MRI corrections and power to track brain change. In 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings (pp. 1172-1175). [6235769] (Proceedings - International Symposium on Biomedical Imaging). https://doi.org/10.1109/ISBI.2012.6235769