Phactr2 and Parkinson's disease

Christian Wider; Sarah J. Lincoln; Michael G. Heckman; Nancy N. Diehl; Jeremy T. Stone; Kristoffer Haugarvoll; Jan O. Aasly; J. Mark Gibson; Timothy Lynch; Alex Rajput; Michele L. Rajput; Ryan J. Uitti; Zbigniew K. Wszolek; Matthew J. Farrer; Owen A. Ross

doi:10.1016/j.neulet.2009.02.009

Phactr2 and Parkinson's disease

Christian Wider, Sarah J. Lincoln, Michael G. Heckman, Nancy N. Diehl, Jeremy T. Stone, Kristoffer Haugarvoll, Jan O. Aasly, J. Mark Gibson, Timothy Lynch, Alex Rajput, Michele L. Rajput, Ryan J. Uitti, Zbigniew K. Wszolek, Matthew J. Farrer, Owen A. Ross

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P = 0.032), Canadian (OR: 1.41, P = 0.014) and Irish (OR: 1.44, P = 0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P = 0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P < 0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.

Original language	English (US)
Pages (from-to)	9-11
Number of pages	3
Journal	Neuroscience Letters
Volume	453
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2009.02.009
State	Published - Mar 27 2009

Keywords

Genome-wide association
Parkinson's disease
Phactr2

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2009.02.009

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title = "Phactr2 and Parkinson's disease",

abstract = "Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P = 0.032), Canadian (OR: 1.41, P = 0.014) and Irish (OR: 1.44, P = 0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P = 0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P < 0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.",

keywords = "Genome-wide association, Parkinson's disease, Phactr2",

author = "Christian Wider and Lincoln, {Sarah J.} and Heckman, {Michael G.} and Diehl, {Nancy N.} and Stone, {Jeremy T.} and Kristoffer Haugarvoll and Aasly, {Jan O.} and Gibson, {J. Mark} and Timothy Lynch and Alex Rajput and Rajput, {Michele L.} and Uitti, {Ryan J.} and Wszolek, {Zbigniew K.} and Farrer, {Matthew J.} and Ross, {Owen A.}",

note = "Funding Information: Mayo Clinic Jacksonville is a Morris K. Udall Parkinson's Disease Research Center of Excellence (NINDS P50 #NS40256) and is supported by a Pacific Alzheimer Research Foundation (PARF) grant C06-01 (RJU, ZKW & MJF). CW is supported by the Swiss National Science Foundation (PASMP3-123268/1).",

year = "2009",

month = mar,

day = "27",

doi = "10.1016/j.neulet.2009.02.009",

language = "English (US)",

volume = "453",

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T1 - Phactr2 and Parkinson's disease

AU - Wider, Christian

AU - Lincoln, Sarah J.

AU - Heckman, Michael G.

AU - Diehl, Nancy N.

AU - Stone, Jeremy T.

AU - Haugarvoll, Kristoffer

AU - Aasly, Jan O.

AU - Gibson, J. Mark

AU - Lynch, Timothy

AU - Rajput, Alex

AU - Rajput, Michele L.

AU - Uitti, Ryan J.

AU - Wszolek, Zbigniew K.

AU - Farrer, Matthew J.

AU - Ross, Owen A.

N1 - Funding Information: Mayo Clinic Jacksonville is a Morris K. Udall Parkinson's Disease Research Center of Excellence (NINDS P50 #NS40256) and is supported by a Pacific Alzheimer Research Foundation (PARF) grant C06-01 (RJU, ZKW & MJF). CW is supported by the Swiss National Science Foundation (PASMP3-123268/1).

PY - 2009/3/27

Y1 - 2009/3/27

N2 - Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P = 0.032), Canadian (OR: 1.41, P = 0.014) and Irish (OR: 1.44, P = 0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P = 0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P < 0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.

AB - Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P = 0.032), Canadian (OR: 1.41, P = 0.014) and Irish (OR: 1.44, P = 0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P = 0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P < 0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.

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KW - Parkinson's disease

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Phactr2 and Parkinson's disease

Abstract

Keywords

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