Phactr2 and Parkinson's disease

Christian Wider, Sarah J. Lincoln, Michael G. Heckman, Nancy N. Diehl, Jeremy T. Stone, Kristoffer Haugarvoll, Jan O. Aasly, J. Mark Gibson, Timothy Lynch, Alex Rajput, Michele L. Rajput, Ryan J. Uitti, Zbigniew K. Wszolek, Matthew J. Farrer, Owen A. Ross

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P = 0.032), Canadian (OR: 1.41, P = 0.014) and Irish (OR: 1.44, P = 0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P = 0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P < 0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.

Original languageEnglish (US)
Pages (from-to)9-11
Number of pages3
JournalNeuroscience Letters
Volume453
Issue number1
DOIs
StatePublished - Mar 27 2009

Keywords

  • Genome-wide association
  • Parkinson's disease
  • Phactr2

ASJC Scopus subject areas

  • Neuroscience(all)

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    Wider, C., Lincoln, S. J., Heckman, M. G., Diehl, N. N., Stone, J. T., Haugarvoll, K., Aasly, J. O., Gibson, J. M., Lynch, T., Rajput, A., Rajput, M. L., Uitti, R. J., Wszolek, Z. K., Farrer, M. J., & Ross, O. A. (2009). Phactr2 and Parkinson's disease. Neuroscience Letters, 453(1), 9-11. https://doi.org/10.1016/j.neulet.2009.02.009