Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

The Cancer Genome Atlas Research Network

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing. A synthesized view on oncogenic processes based on PanCancer Atlas analyses highlights the complex impact of genome alterations on the signaling and multi-omic profiles of human cancers as well as their influence on tumor microenvironment.

Original languageEnglish (US)
Pages (from-to)305-320.e10
JournalCell
Volume173
Issue number2
DOIs
StatePublished - Apr 5 2018

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Genomics
Tumors
Genes
Neoplasms
Atlases
Genome
Tumor Microenvironment
Proteome
Anchors
Carcinogenesis
Germ-Line Mutation
Drug Delivery Systems
Transcriptome
Immunotherapy

Keywords

  • cancer
  • cancer genomics
  • omics
  • oncogenic process
  • TCGA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics. / The Cancer Genome Atlas Research Network.

In: Cell, Vol. 173, No. 2, 05.04.2018, p. 305-320.e10.

Research output: Contribution to journalArticle

The Cancer Genome Atlas Research Network 2018, 'Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics', Cell, vol. 173, no. 2, pp. 305-320.e10. https://doi.org/10.1016/j.cell.2018.03.033
The Cancer Genome Atlas Research Network. / Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics. In: Cell. 2018 ; Vol. 173, No. 2. pp. 305-320.e10.
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abstract = "The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing. A synthesized view on oncogenic processes based on PanCancer Atlas analyses highlights the complex impact of genome alterations on the signaling and multi-omic profiles of human cancers as well as their influence on tumor microenvironment.",
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