Personalized vaccines: The emerging field of vaccinomics

Gregory A. Poland, Inna G. Ovsyannikova, Robert M. Jacobson

Research output: Contribution to journalReview article

103 Scopus citations

Abstract

The next 'golden age' in vaccinology will be ushered in by the new science of vaccinomics. In turn, this will inform and allow the development of personalized vaccines, based on our increasing understanding of immune response phenotype: genotype information. Rapid advances in developing such data are already occurring for hepatitis B, influenza, measles, mumps, rubella, anthrax and smallpox vaccines. In addition, newly available data suggest that some vaccine-related adverse events may also be genetically determined and, therefore, predictable. This paper reviews the basis and logic of personalized vaccines, and describes recent advances in the field.

Original languageEnglish (US)
Pages (from-to)1659-1667
Number of pages9
JournalExpert Opinion on Biological Therapy
Volume8
Issue number11
DOIs
StatePublished - Nov 2008

Keywords

  • Gene association studies
  • Gene polymorphism
  • HLA
  • Immunogenetics
  • Single nucleotide polymorphisms
  • Vaccinomics

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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