TY - JOUR
T1 - Personalized vaccines
T2 - The emerging field of vaccinomics
AU - Poland, Gregory A.
AU - Ovsyannikova, Inna G.
AU - Jacobson, Robert M.
N1 - Funding Information:
We thank CA Hart for her editorial assistance. In addition we acknowledge support from National Institutes of Health grants AI 33144, AI 48793 and AI 40065 for this work.
PY - 2008/11
Y1 - 2008/11
N2 - The next 'golden age' in vaccinology will be ushered in by the new science of vaccinomics. In turn, this will inform and allow the development of personalized vaccines, based on our increasing understanding of immune response phenotype: genotype information. Rapid advances in developing such data are already occurring for hepatitis B, influenza, measles, mumps, rubella, anthrax and smallpox vaccines. In addition, newly available data suggest that some vaccine-related adverse events may also be genetically determined and, therefore, predictable. This paper reviews the basis and logic of personalized vaccines, and describes recent advances in the field.
AB - The next 'golden age' in vaccinology will be ushered in by the new science of vaccinomics. In turn, this will inform and allow the development of personalized vaccines, based on our increasing understanding of immune response phenotype: genotype information. Rapid advances in developing such data are already occurring for hepatitis B, influenza, measles, mumps, rubella, anthrax and smallpox vaccines. In addition, newly available data suggest that some vaccine-related adverse events may also be genetically determined and, therefore, predictable. This paper reviews the basis and logic of personalized vaccines, and describes recent advances in the field.
KW - Gene association studies
KW - Gene polymorphism
KW - HLA
KW - Immunogenetics
KW - Single nucleotide polymorphisms
KW - Vaccinomics
UR - http://www.scopus.com/inward/record.url?scp=56249122606&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56249122606&partnerID=8YFLogxK
U2 - 10.1517/14712598.8.11.1659
DO - 10.1517/14712598.8.11.1659
M3 - Review article
C2 - 18847302
AN - SCOPUS:56249122606
SN - 1471-2598
VL - 8
SP - 1659
EP - 1667
JO - Expert Opinion on Biological Therapy
JF - Expert Opinion on Biological Therapy
IS - 11
ER -