Permeability of cortical bone of canine tibiae

Guoping Li, James T. Bronk, Kai Nan An, Patrick J. Kelly

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Movement of interstitial fluid in cortical bone is considered one of the important mechanisms affecting bone remodeling and fracture healing. To better understand such interstitial fluid movement, the hydrostatic permeability of cortical bone of the canine tibia was measured in this study. It was found that age has significant influence on permeability. The cortical bone permeability of puppy tibiae is six times higher than that of adult tibiae. Adult tibial cortex is impermeable unless the superficial layer of the periosteal cortex is removed. The permeability differs between regions and locations of the tibia. The pathways for such extravascular interstitial fluid movement were also identified to be primarily the haversian and Volkmann's canals and secondarily the canalicular and lacunar spaces. The high permeability of their cortical bone may explain the increase in periosteal new bone formation seen in puppies when a venous tourniquet is applied.

Original languageEnglish (US)
Pages (from-to)302-310
Number of pages9
JournalMicrovascular Research
Volume34
Issue number3
DOIs
StatePublished - Nov 1987

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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    Li, G., Bronk, J. T., An, K. N., & Kelly, P. J. (1987). Permeability of cortical bone of canine tibiae. Microvascular Research, 34(3), 302-310. https://doi.org/10.1016/0026-2862(87)90063-X