Peripheral mechanisms in appetite regulation

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Peripheral mechanisms in appetite regulation include the motor functions of the stomach, such as the rate of emptying and accommodation, which convey symptoms of satiation to the brain. The rich repertoire of peripherally released peptides and hormones provides feedback from the arrival of nutrients in different regions of the gut from where they are released to exert effects on satiation, or regulate metabolism through their incretin effects. Ultimately, these peripheral factors provide input to the highly organized hypothalamic circuitry and vagal complex of nuclei to determine cessation of energy intake during meal ingestion, and the return of appetite and hunger after fasting. Understanding these mechanisms is key to the physiological control of feeding and the derangements that occur in obesity and their restoration with treatment (as shown by the effects of bariatric surgery).

Original languageEnglish (US)
Pages (from-to)1219-1233
Number of pages15
JournalGastroenterology
Volume148
Issue number6
DOIs
StatePublished - May 1 2015

Fingerprint

Satiation
Appetite Regulation
Incretins
Hunger
Bariatric Surgery
Peptide Hormones
Appetite
Energy Intake
Meals
Fasting
Stomach
Obesity
Eating
Food
Brain
Therapeutics

Keywords

  • Neurohormonal
  • Satiation
  • Satiety
  • Stomach

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Peripheral mechanisms in appetite regulation. / Camilleri, Michael.

In: Gastroenterology, Vol. 148, No. 6, 01.05.2015, p. 1219-1233.

Research output: Contribution to journalArticle

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