Peripheral lymphoid tissue-like adhesion molecule expression in nodular infiltrates in inflammatory myopathies

J. L. De Bleecker, A. G. Engel, E. C. Butcher

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Non-granulomatous nodular accumulations of inflammatory cells in inflammatory myopathies were studied to characterize adhesion mechanisms used for leukocyte recruitment. The nodules had a B-cell-rich center surrounded by a helper T-cell-rich peripheral zone, resembling lymph nodes. The T-cell-rich zones harbored high-walled venules resembling high endothelial venules (HEV), whose endothelia frequently expressed ICAM-1, VCAM-1, and less constantly E-selectin. This endothelial adhesion molecule profile differs from that found in polymyositis, inclusion body myositis, or dermatomyositis, but resembles that in lymphoid tissues. Also, the peripheral lymph node addressin, a vascular addressin specific for peripheral lymphoid tissue HEV, was present on many HEV. This adhesion system is probably responsible for the excessive lymphocyte recruitment. The similar cellular organization and lymphocyte recirculation mechanisms of the nodular infiltrates in muscle and of lymph nodes suggest that the former may also produce antibodies.

Original languageEnglish (US)
Pages (from-to)255-260
Number of pages6
JournalNeuromuscular Disorders
Volume6
Issue number4
DOIs
StatePublished - Aug 1996

Keywords

  • Adhesion molecules
  • Immunohistochemistry
  • Immunology
  • Inflammatory myopathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Clinical Neurology
  • Genetics(clinical)

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