Peripheral and cranial nerve sheath tumors

Maciej Mrugala, Tracy T. Batchelor, Scott R. Plotkin

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Purpose of review: The intention of the authors is to provide the reader with an overview of the recent advances in the diagnosis and treatment of nerve sheath tumors. Vestibular schwannomas, neurogenetic syndromes such as schwannomatosis and multiple isolated neurofibromas, and malignant peripheral nerve sheath tumors are covered in this review. Recent findings: Over the last year, literature focusing on different management strategies for patients with vestibular schwannomas dominated the field. Surgical options for this group of patients are changing. Stereotactic radiation is also employed more frequently with promising results. New insights into the biology of peripheral nerve tumor development and growth, including expression of vascular endothelial growth factor by vestibular schwannomas and the role of Notch signaling in malignant transformation of benign neurofibromas have been described. Diagnostic criteria for schwannomatosis, a recently described condition, are being developed. Several cases of multiple isolated neurofibromas and spinal neurofibromas were reported. Summary: Peripheral nerve tumors are classified according to the specific features of cellular differentiation. The most common types include schwannoma and neurofibroma. These tumors can occur sporadically or as manifestations of genetic syndromes such as neurofibromatosis types 1 and 2 or schwannomatosis. The majority of peripheral nerve tumors are benign but malignant transformation does occur. Metastatic tumors can also affect peripheral nerves. The diagnostic modality of choice is magnetic resonance imaging. Positron emission tomography is a useful technique in the presurgical differentiation between benign and malignant peripheral nerve sheath tumors. Treatment is directed towards symptomatic control. Surgery, radiation and, in rare instances, chemotherapy are the major treatment modalities employed.

Original languageEnglish (US)
Pages (from-to)604-610
Number of pages7
JournalCurrent opinion in neurology
Volume18
Issue number5
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

Peripheral Nervous System Neoplasms
Nerve Sheath Neoplasms
Neurofibroma
Acoustic Neuroma
Cranial Nerves
Neurilemmoma
Neurofibromatoses
Radiation
Neurofibromatosis 2
Neurofibromatosis 1
Growth and Development
Peripheral Nerves
Positron-Emission Tomography
Vascular Endothelial Growth Factor A
Neoplasms
Therapeutics
Magnetic Resonance Imaging
Drug Therapy
Schwannomatosis

Keywords

  • Neurofibromatosis
  • Peripheral nerve sheath tumor
  • Schwannoma
  • Schwannomatosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Peripheral and cranial nerve sheath tumors. / Mrugala, Maciej; Batchelor, Tracy T.; Plotkin, Scott R.

In: Current opinion in neurology, Vol. 18, No. 5, 01.01.2005, p. 604-610.

Research output: Contribution to journalReview article

Mrugala, Maciej ; Batchelor, Tracy T. ; Plotkin, Scott R. / Peripheral and cranial nerve sheath tumors. In: Current opinion in neurology. 2005 ; Vol. 18, No. 5. pp. 604-610.
@article{f6356d2cb8c24f49b21074253946c66c,
title = "Peripheral and cranial nerve sheath tumors",
abstract = "Purpose of review: The intention of the authors is to provide the reader with an overview of the recent advances in the diagnosis and treatment of nerve sheath tumors. Vestibular schwannomas, neurogenetic syndromes such as schwannomatosis and multiple isolated neurofibromas, and malignant peripheral nerve sheath tumors are covered in this review. Recent findings: Over the last year, literature focusing on different management strategies for patients with vestibular schwannomas dominated the field. Surgical options for this group of patients are changing. Stereotactic radiation is also employed more frequently with promising results. New insights into the biology of peripheral nerve tumor development and growth, including expression of vascular endothelial growth factor by vestibular schwannomas and the role of Notch signaling in malignant transformation of benign neurofibromas have been described. Diagnostic criteria for schwannomatosis, a recently described condition, are being developed. Several cases of multiple isolated neurofibromas and spinal neurofibromas were reported. Summary: Peripheral nerve tumors are classified according to the specific features of cellular differentiation. The most common types include schwannoma and neurofibroma. These tumors can occur sporadically or as manifestations of genetic syndromes such as neurofibromatosis types 1 and 2 or schwannomatosis. The majority of peripheral nerve tumors are benign but malignant transformation does occur. Metastatic tumors can also affect peripheral nerves. The diagnostic modality of choice is magnetic resonance imaging. Positron emission tomography is a useful technique in the presurgical differentiation between benign and malignant peripheral nerve sheath tumors. Treatment is directed towards symptomatic control. Surgery, radiation and, in rare instances, chemotherapy are the major treatment modalities employed.",
keywords = "Neurofibromatosis, Peripheral nerve sheath tumor, Schwannoma, Schwannomatosis",
author = "Maciej Mrugala and Batchelor, {Tracy T.} and Plotkin, {Scott R.}",
year = "2005",
month = "1",
day = "1",
doi = "10.1097/01.wco.0000179507.51647.02",
language = "English (US)",
volume = "18",
pages = "604--610",
journal = "Current Opinion in Neurology",
issn = "1350-7540",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Peripheral and cranial nerve sheath tumors

AU - Mrugala, Maciej

AU - Batchelor, Tracy T.

AU - Plotkin, Scott R.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Purpose of review: The intention of the authors is to provide the reader with an overview of the recent advances in the diagnosis and treatment of nerve sheath tumors. Vestibular schwannomas, neurogenetic syndromes such as schwannomatosis and multiple isolated neurofibromas, and malignant peripheral nerve sheath tumors are covered in this review. Recent findings: Over the last year, literature focusing on different management strategies for patients with vestibular schwannomas dominated the field. Surgical options for this group of patients are changing. Stereotactic radiation is also employed more frequently with promising results. New insights into the biology of peripheral nerve tumor development and growth, including expression of vascular endothelial growth factor by vestibular schwannomas and the role of Notch signaling in malignant transformation of benign neurofibromas have been described. Diagnostic criteria for schwannomatosis, a recently described condition, are being developed. Several cases of multiple isolated neurofibromas and spinal neurofibromas were reported. Summary: Peripheral nerve tumors are classified according to the specific features of cellular differentiation. The most common types include schwannoma and neurofibroma. These tumors can occur sporadically or as manifestations of genetic syndromes such as neurofibromatosis types 1 and 2 or schwannomatosis. The majority of peripheral nerve tumors are benign but malignant transformation does occur. Metastatic tumors can also affect peripheral nerves. The diagnostic modality of choice is magnetic resonance imaging. Positron emission tomography is a useful technique in the presurgical differentiation between benign and malignant peripheral nerve sheath tumors. Treatment is directed towards symptomatic control. Surgery, radiation and, in rare instances, chemotherapy are the major treatment modalities employed.

AB - Purpose of review: The intention of the authors is to provide the reader with an overview of the recent advances in the diagnosis and treatment of nerve sheath tumors. Vestibular schwannomas, neurogenetic syndromes such as schwannomatosis and multiple isolated neurofibromas, and malignant peripheral nerve sheath tumors are covered in this review. Recent findings: Over the last year, literature focusing on different management strategies for patients with vestibular schwannomas dominated the field. Surgical options for this group of patients are changing. Stereotactic radiation is also employed more frequently with promising results. New insights into the biology of peripheral nerve tumor development and growth, including expression of vascular endothelial growth factor by vestibular schwannomas and the role of Notch signaling in malignant transformation of benign neurofibromas have been described. Diagnostic criteria for schwannomatosis, a recently described condition, are being developed. Several cases of multiple isolated neurofibromas and spinal neurofibromas were reported. Summary: Peripheral nerve tumors are classified according to the specific features of cellular differentiation. The most common types include schwannoma and neurofibroma. These tumors can occur sporadically or as manifestations of genetic syndromes such as neurofibromatosis types 1 and 2 or schwannomatosis. The majority of peripheral nerve tumors are benign but malignant transformation does occur. Metastatic tumors can also affect peripheral nerves. The diagnostic modality of choice is magnetic resonance imaging. Positron emission tomography is a useful technique in the presurgical differentiation between benign and malignant peripheral nerve sheath tumors. Treatment is directed towards symptomatic control. Surgery, radiation and, in rare instances, chemotherapy are the major treatment modalities employed.

KW - Neurofibromatosis

KW - Peripheral nerve sheath tumor

KW - Schwannoma

KW - Schwannomatosis

UR - http://www.scopus.com/inward/record.url?scp=26944497220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26944497220&partnerID=8YFLogxK

U2 - 10.1097/01.wco.0000179507.51647.02

DO - 10.1097/01.wco.0000179507.51647.02

M3 - Review article

C2 - 16155448

AN - SCOPUS:26944497220

VL - 18

SP - 604

EP - 610

JO - Current Opinion in Neurology

JF - Current Opinion in Neurology

SN - 1350-7540

IS - 5

ER -