Perioperative Morbidity of Lymph Node Dissection for Renal Cell Carcinoma

A Propensity Score-based Analysis

Boris Gershman, Daniel M. Moreira, R. Houston Thompson, Stephen A. Boorjian, Christine M. Lohse, Brian Costello, John C. Cheville, Bradley C. Leibovich

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: There are little data regarding the morbidity of lymph node dissection (LND) for renal cell carcinoma (RCC) to assess its risk-benefit ratio. Objective: To evaluate the association of LND with 30-d complications among patients undergoing radical nephrectomy (RN) for RCC. Design, setting, and participants: A total of 2066 patients underwent RN for M0 or M1 RCC between 1990 and 2010, of whom 774 (37%) underwent LND. Intervention: RN with or without LND. Outcome measurements and statistical analysis: Associations of LND with 30-d complications were examined using logistic regression with several propensity score techniques. Extended LND, defined as removal of ≥13 lymph nodes, was examined in a sensitivity analysis. Results and limitations: A total of 184 (9%) patients were pN1 and 302 (15%) were M1. Thirty-day complications occurred in 194 (9%) patients, including Clavien grade ≥3 complications in 81 (4%) patients. Clinicopathologic features were well balanced after propensity score adjustment. In the overall cohort, LND was not statistically significantly associated with Clavien grade ≥3 complications, although there was an approximately 40% increased risk of any Clavien grade complication that did not reach statistical significance. Likewise, LND was not significantly associated with any Clavien grade or Clavien grade ≥3 complications when separately evaluated among M0 or M1 patients. Extended LND was not significantly associated with any Clavien grade or Clavien grade ≥3 complications. LND was not associated with length of stay or estimated blood loss. Limitations include a retrospective design. Conclusions: LND is not significantly associated with an increased risk of Clavien grade ≥3 complications, although it may be associated with a modestly increased risk of minor complications. In the absence of increased morbidity, LND may be justified in a predominantly staging role in the management of RCC. Patient summary: Lymph node dissection for renal cell carcinoma is not associated with increased rates of major complications. Lymph node dissection for renal cell carcinoma is not associated with increased rates of major complications among patients undergoing radical nephrectomy.

Original languageEnglish (US)
JournalEuropean Urology
DOIs
StateAccepted/In press - Jan 1 2017

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Propensity Score
Lymph Node Excision
Renal Cell Carcinoma
Morbidity
Nephrectomy

Keywords

  • Complications
  • Lymph node dissection
  • Nephrectomy
  • Propensity score
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Gershman, B., Moreira, D. M., Thompson, R. H., Boorjian, S. A., Lohse, C. M., Costello, B., ... Leibovich, B. C. (Accepted/In press). Perioperative Morbidity of Lymph Node Dissection for Renal Cell Carcinoma: A Propensity Score-based Analysis. European Urology. https://doi.org/10.1016/j.eururo.2017.10.020

Perioperative Morbidity of Lymph Node Dissection for Renal Cell Carcinoma : A Propensity Score-based Analysis. / Gershman, Boris; Moreira, Daniel M.; Thompson, R. Houston; Boorjian, Stephen A.; Lohse, Christine M.; Costello, Brian; Cheville, John C.; Leibovich, Bradley C.

In: European Urology, 01.01.2017.

Research output: Contribution to journalArticle

Gershman, Boris ; Moreira, Daniel M. ; Thompson, R. Houston ; Boorjian, Stephen A. ; Lohse, Christine M. ; Costello, Brian ; Cheville, John C. ; Leibovich, Bradley C. / Perioperative Morbidity of Lymph Node Dissection for Renal Cell Carcinoma : A Propensity Score-based Analysis. In: European Urology. 2017.
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abstract = "Background: There are little data regarding the morbidity of lymph node dissection (LND) for renal cell carcinoma (RCC) to assess its risk-benefit ratio. Objective: To evaluate the association of LND with 30-d complications among patients undergoing radical nephrectomy (RN) for RCC. Design, setting, and participants: A total of 2066 patients underwent RN for M0 or M1 RCC between 1990 and 2010, of whom 774 (37{\%}) underwent LND. Intervention: RN with or without LND. Outcome measurements and statistical analysis: Associations of LND with 30-d complications were examined using logistic regression with several propensity score techniques. Extended LND, defined as removal of ≥13 lymph nodes, was examined in a sensitivity analysis. Results and limitations: A total of 184 (9{\%}) patients were pN1 and 302 (15{\%}) were M1. Thirty-day complications occurred in 194 (9{\%}) patients, including Clavien grade ≥3 complications in 81 (4{\%}) patients. Clinicopathologic features were well balanced after propensity score adjustment. In the overall cohort, LND was not statistically significantly associated with Clavien grade ≥3 complications, although there was an approximately 40{\%} increased risk of any Clavien grade complication that did not reach statistical significance. Likewise, LND was not significantly associated with any Clavien grade or Clavien grade ≥3 complications when separately evaluated among M0 or M1 patients. Extended LND was not significantly associated with any Clavien grade or Clavien grade ≥3 complications. LND was not associated with length of stay or estimated blood loss. Limitations include a retrospective design. Conclusions: LND is not significantly associated with an increased risk of Clavien grade ≥3 complications, although it may be associated with a modestly increased risk of minor complications. In the absence of increased morbidity, LND may be justified in a predominantly staging role in the management of RCC. Patient summary: Lymph node dissection for renal cell carcinoma is not associated with increased rates of major complications. Lymph node dissection for renal cell carcinoma is not associated with increased rates of major complications among patients undergoing radical nephrectomy.",
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T2 - A Propensity Score-based Analysis

AU - Gershman, Boris

AU - Moreira, Daniel M.

AU - Thompson, R. Houston

AU - Boorjian, Stephen A.

AU - Lohse, Christine M.

AU - Costello, Brian

AU - Cheville, John C.

AU - Leibovich, Bradley C.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: There are little data regarding the morbidity of lymph node dissection (LND) for renal cell carcinoma (RCC) to assess its risk-benefit ratio. Objective: To evaluate the association of LND with 30-d complications among patients undergoing radical nephrectomy (RN) for RCC. Design, setting, and participants: A total of 2066 patients underwent RN for M0 or M1 RCC between 1990 and 2010, of whom 774 (37%) underwent LND. Intervention: RN with or without LND. Outcome measurements and statistical analysis: Associations of LND with 30-d complications were examined using logistic regression with several propensity score techniques. Extended LND, defined as removal of ≥13 lymph nodes, was examined in a sensitivity analysis. Results and limitations: A total of 184 (9%) patients were pN1 and 302 (15%) were M1. Thirty-day complications occurred in 194 (9%) patients, including Clavien grade ≥3 complications in 81 (4%) patients. Clinicopathologic features were well balanced after propensity score adjustment. In the overall cohort, LND was not statistically significantly associated with Clavien grade ≥3 complications, although there was an approximately 40% increased risk of any Clavien grade complication that did not reach statistical significance. Likewise, LND was not significantly associated with any Clavien grade or Clavien grade ≥3 complications when separately evaluated among M0 or M1 patients. Extended LND was not significantly associated with any Clavien grade or Clavien grade ≥3 complications. LND was not associated with length of stay or estimated blood loss. Limitations include a retrospective design. Conclusions: LND is not significantly associated with an increased risk of Clavien grade ≥3 complications, although it may be associated with a modestly increased risk of minor complications. In the absence of increased morbidity, LND may be justified in a predominantly staging role in the management of RCC. Patient summary: Lymph node dissection for renal cell carcinoma is not associated with increased rates of major complications. Lymph node dissection for renal cell carcinoma is not associated with increased rates of major complications among patients undergoing radical nephrectomy.

AB - Background: There are little data regarding the morbidity of lymph node dissection (LND) for renal cell carcinoma (RCC) to assess its risk-benefit ratio. Objective: To evaluate the association of LND with 30-d complications among patients undergoing radical nephrectomy (RN) for RCC. Design, setting, and participants: A total of 2066 patients underwent RN for M0 or M1 RCC between 1990 and 2010, of whom 774 (37%) underwent LND. Intervention: RN with or without LND. Outcome measurements and statistical analysis: Associations of LND with 30-d complications were examined using logistic regression with several propensity score techniques. Extended LND, defined as removal of ≥13 lymph nodes, was examined in a sensitivity analysis. Results and limitations: A total of 184 (9%) patients were pN1 and 302 (15%) were M1. Thirty-day complications occurred in 194 (9%) patients, including Clavien grade ≥3 complications in 81 (4%) patients. Clinicopathologic features were well balanced after propensity score adjustment. In the overall cohort, LND was not statistically significantly associated with Clavien grade ≥3 complications, although there was an approximately 40% increased risk of any Clavien grade complication that did not reach statistical significance. Likewise, LND was not significantly associated with any Clavien grade or Clavien grade ≥3 complications when separately evaluated among M0 or M1 patients. Extended LND was not significantly associated with any Clavien grade or Clavien grade ≥3 complications. LND was not associated with length of stay or estimated blood loss. Limitations include a retrospective design. Conclusions: LND is not significantly associated with an increased risk of Clavien grade ≥3 complications, although it may be associated with a modestly increased risk of minor complications. In the absence of increased morbidity, LND may be justified in a predominantly staging role in the management of RCC. Patient summary: Lymph node dissection for renal cell carcinoma is not associated with increased rates of major complications. Lymph node dissection for renal cell carcinoma is not associated with increased rates of major complications among patients undergoing radical nephrectomy.

KW - Complications

KW - Lymph node dissection

KW - Nephrectomy

KW - Propensity score

KW - Renal cell carcinoma

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