Perineural tumor spread of bladder cancer causing lumbosacral plexopathy: an anatomic explanation

Daniel M. Aghion; Stepan Capek; Benjamin M. Howe; Jaroslaw T. Hepel; Sundaresan Sambandam; Adeotounbo A. Oyelese; Robert J. Spinner

doi:10.1007/s00701-014-2257-8

Perineural tumor spread of bladder cancer causing lumbosacral plexopathy: an anatomic explanation

Daniel M. Aghion, Stepan Capek, Benjamin M. Howe, Jaroslaw T. Hepel, Sundaresan Sambandam, Adeotounbo A. Oyelese, Robert J. Spinner

Neurosurgery

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

We present two cases of biopsy-proven neoplastic lumbosacral plexopathy from perineural spread of bladder cancer: one patient presented with predominantly sciatic nerve involvement and the second predominantly with obturator nerve involvement. These two patterns of perineural spread from bladder cancer were supported by imaging in our cases and solidified by review of the literature. Based on the innervation of the bladder, we provide an anatomic explanation for this observation. To our best knowledge, such an anatomic, mechanistic basis for perineural tumor spread in bladder cancer has not yet been described.

Original language	English (US)
Pages (from-to)	2331-2336
Number of pages	6
Journal	Acta Neurochirurgica
Volume	156
Issue number	12
DOIs	https://doi.org/10.1007/s00701-014-2257-8
State	Published - Nov 16 2014

Keywords

Bladder cancer
Lumbosacral plexopathy
Obturator neuropathy
Perineural tumor spread
Sciatic neuropathy

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1007/s00701-014-2257-8

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Aghion, D. M., Capek, S., Howe, B. M., Hepel, J. T., Sambandam, S., Oyelese, A. A., & Spinner, R. J. (2014). Perineural tumor spread of bladder cancer causing lumbosacral plexopathy: an anatomic explanation. Acta Neurochirurgica, 156(12), 2331-2336. https://doi.org/10.1007/s00701-014-2257-8

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abstract = "We present two cases of biopsy-proven neoplastic lumbosacral plexopathy from perineural spread of bladder cancer: one patient presented with predominantly sciatic nerve involvement and the second predominantly with obturator nerve involvement. These two patterns of perineural spread from bladder cancer were supported by imaging in our cases and solidified by review of the literature. Based on the innervation of the bladder, we provide an anatomic explanation for this observation. To our best knowledge, such an anatomic, mechanistic basis for perineural tumor spread in bladder cancer has not yet been described.",

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