Abstract
It has previously been suggested that abnormalities in cardiac repolarization (QTc lengthening and shortening) are more likely to accompany seizures with hypoxemia and may be involved in sudden unexpected death in epilepsy (SUDEP). Accordingly, we evaluated for associations between peri-ictal QTc changes and hypoxemia. We performed a reanalysis of cardiac and respiratory data gathered prospectively in our epilepsy monitoring units. The Bazett, Fridericia, Framingham, and Hodges heart rate correction formulas were utilized to calculate QTc in the pre-ictal, ictal, and post-ictal periods. Hypoxemia (defined as a drop in oxygen saturation below 90% for at least four contiguous seconds) was also examined during identical periods. Fifty-eight seizures from 29 patients were analyzed. Peri-ictal hypoxemia was not rare, occurring in 18/58 (31%) seizures. QTc lengthening was more commonly observed than shortening, with 11/58 (19%) seizures demonstrating peri-ictal QTc values. ≥. 500 using the Bazett formula. There was no significant difference between the minimum and maximum QTc values in seizures with and without peri-ictal hypoxemia, regardless of the correction formula utilized. All examined parameters of QTc lengthening and shortening were not associated with peri-ictal hypoxemia. This suggests that factors other than hypoxia result in peri-ictal cardiac repolarization abnormalities.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 982-985 |
| Number of pages | 4 |
| Journal | Epilepsy Research |
| Volume | 108 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Cardiac repolarization
- Hypoxemia
- Peri-ictal autonomic changes
- QTc
- SUDEP
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Medicine(all)
Cite this
Peri-ictal QTc changes are not associated with hypoxemia. / Moseley, Brian D.; Britton, Jeffrey W.
In: Epilepsy Research, Vol. 108, No. 5, 2014, p. 982-985.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peri-ictal QTc changes are not associated with hypoxemia
AU - Moseley, Brian D.
AU - Britton, Jeffrey W.
PY - 2014
Y1 - 2014
N2 - It has previously been suggested that abnormalities in cardiac repolarization (QTc lengthening and shortening) are more likely to accompany seizures with hypoxemia and may be involved in sudden unexpected death in epilepsy (SUDEP). Accordingly, we evaluated for associations between peri-ictal QTc changes and hypoxemia. We performed a reanalysis of cardiac and respiratory data gathered prospectively in our epilepsy monitoring units. The Bazett, Fridericia, Framingham, and Hodges heart rate correction formulas were utilized to calculate QTc in the pre-ictal, ictal, and post-ictal periods. Hypoxemia (defined as a drop in oxygen saturation below 90% for at least four contiguous seconds) was also examined during identical periods. Fifty-eight seizures from 29 patients were analyzed. Peri-ictal hypoxemia was not rare, occurring in 18/58 (31%) seizures. QTc lengthening was more commonly observed than shortening, with 11/58 (19%) seizures demonstrating peri-ictal QTc values. ≥. 500 using the Bazett formula. There was no significant difference between the minimum and maximum QTc values in seizures with and without peri-ictal hypoxemia, regardless of the correction formula utilized. All examined parameters of QTc lengthening and shortening were not associated with peri-ictal hypoxemia. This suggests that factors other than hypoxia result in peri-ictal cardiac repolarization abnormalities.
AB - It has previously been suggested that abnormalities in cardiac repolarization (QTc lengthening and shortening) are more likely to accompany seizures with hypoxemia and may be involved in sudden unexpected death in epilepsy (SUDEP). Accordingly, we evaluated for associations between peri-ictal QTc changes and hypoxemia. We performed a reanalysis of cardiac and respiratory data gathered prospectively in our epilepsy monitoring units. The Bazett, Fridericia, Framingham, and Hodges heart rate correction formulas were utilized to calculate QTc in the pre-ictal, ictal, and post-ictal periods. Hypoxemia (defined as a drop in oxygen saturation below 90% for at least four contiguous seconds) was also examined during identical periods. Fifty-eight seizures from 29 patients were analyzed. Peri-ictal hypoxemia was not rare, occurring in 18/58 (31%) seizures. QTc lengthening was more commonly observed than shortening, with 11/58 (19%) seizures demonstrating peri-ictal QTc values. ≥. 500 using the Bazett formula. There was no significant difference between the minimum and maximum QTc values in seizures with and without peri-ictal hypoxemia, regardless of the correction formula utilized. All examined parameters of QTc lengthening and shortening were not associated with peri-ictal hypoxemia. This suggests that factors other than hypoxia result in peri-ictal cardiac repolarization abnormalities.
KW - Cardiac repolarization
KW - Hypoxemia
KW - Peri-ictal autonomic changes
KW - QTc
KW - SUDEP
UR - http://www.scopus.com/inward/record.url?scp=84900515991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900515991&partnerID=8YFLogxK
U2 - 10.1016/j.eplepsyres.2014.03.016
DO - 10.1016/j.eplepsyres.2014.03.016
M3 - Article
VL - 108
SP - 982
EP - 985
JO - Epilepsy Research
JF - Epilepsy Research
SN - 0920-1211
IS - 5
ER -