Percutaneous Revascularization for Stable Coronary Artery Disease. Temporal Trends and Impact of Drug-Eluting Stents

Anthony A. Hilliard, Aaron M. From, Ryan J. Lennon, Mandeep Singh, Amir Lerman, Bernard J. Gersh, David Holmes, Charanjit Rihal, Abhiram Prasad

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objectives: We sought to determine the characteristics, outcomes, and temporal trends among patients undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) from a single-center registry. Background: There is controversy regarding the generalizability of the findings from randomized trials of PCI for stable CAD to daily practice. An important perspective on the significance of the trial results can be achieved by clearly documenting past and present practice of PCI. Methods: This was a retrospective analysis of 8,912 consecutive patients undergoing elective PCI from 1979 through 2006 at a tertiary referral center. Clinical, angiographic, and procedural characteristics as well as in-hospital and long-term outcomes were measured in patients grouped into 4 eras depending on the dominant interventional strategy of that time: percutaneous transluminal coronary angioplasty, early stent, bare-metal stent, and drug-eluting stent. Results: Procedural success rates have improved (81%, 92%, 96%, and 97%, respectively, p < 0.001), and in-hospital mortality has decreased significantly (1.0%, 0.8%, 0.1%, and 0.1%, respectively, p < 0.001) over time. Kaplan-Meier estimates of mortality at 4 years were 11%, 13%, 10%, and 10%, respectively (p = 0.4). The 1-year target lesion revascularization rates in the 4 groups were 29%, 26%, 13%, and 8%, respectively (p < 0.001). Conclusions: Procedural success rates in contemporary practice of PCI for stable CAD are excellent with very low in-hospital mortality. Introduction of drug-eluting stents has reduced target lesion revascularization but not mortality among all comers. Outcomes similar to that observed in recent clinical trials are being achieved in routine clinical practice.

Original languageEnglish (US)
Pages (from-to)172-179
Number of pages8
JournalJACC: Cardiovascular Interventions
Volume3
Issue number2
DOIs
StatePublished - Feb 2010

Fingerprint

Drug-Eluting Stents
Percutaneous Coronary Intervention
Coronary Artery Disease
Hospital Mortality
Stents
Coronary Balloon Angioplasty
Mortality
Kaplan-Meier Estimate
Tertiary Care Centers
Registries
Metals
Clinical Trials

Keywords

  • angina
  • angioplasty
  • coronary artery disease
  • outcomes
  • stents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Percutaneous Revascularization for Stable Coronary Artery Disease. Temporal Trends and Impact of Drug-Eluting Stents. / Hilliard, Anthony A.; From, Aaron M.; Lennon, Ryan J.; Singh, Mandeep; Lerman, Amir; Gersh, Bernard J.; Holmes, David; Rihal, Charanjit; Prasad, Abhiram.

In: JACC: Cardiovascular Interventions, Vol. 3, No. 2, 02.2010, p. 172-179.

Research output: Contribution to journalArticle

Hilliard, Anthony A. ; From, Aaron M. ; Lennon, Ryan J. ; Singh, Mandeep ; Lerman, Amir ; Gersh, Bernard J. ; Holmes, David ; Rihal, Charanjit ; Prasad, Abhiram. / Percutaneous Revascularization for Stable Coronary Artery Disease. Temporal Trends and Impact of Drug-Eluting Stents. In: JACC: Cardiovascular Interventions. 2010 ; Vol. 3, No. 2. pp. 172-179.
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abstract = "Objectives: We sought to determine the characteristics, outcomes, and temporal trends among patients undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) from a single-center registry. Background: There is controversy regarding the generalizability of the findings from randomized trials of PCI for stable CAD to daily practice. An important perspective on the significance of the trial results can be achieved by clearly documenting past and present practice of PCI. Methods: This was a retrospective analysis of 8,912 consecutive patients undergoing elective PCI from 1979 through 2006 at a tertiary referral center. Clinical, angiographic, and procedural characteristics as well as in-hospital and long-term outcomes were measured in patients grouped into 4 eras depending on the dominant interventional strategy of that time: percutaneous transluminal coronary angioplasty, early stent, bare-metal stent, and drug-eluting stent. Results: Procedural success rates have improved (81{\%}, 92{\%}, 96{\%}, and 97{\%}, respectively, p < 0.001), and in-hospital mortality has decreased significantly (1.0{\%}, 0.8{\%}, 0.1{\%}, and 0.1{\%}, respectively, p < 0.001) over time. Kaplan-Meier estimates of mortality at 4 years were 11{\%}, 13{\%}, 10{\%}, and 10{\%}, respectively (p = 0.4). The 1-year target lesion revascularization rates in the 4 groups were 29{\%}, 26{\%}, 13{\%}, and 8{\%}, respectively (p < 0.001). Conclusions: Procedural success rates in contemporary practice of PCI for stable CAD are excellent with very low in-hospital mortality. Introduction of drug-eluting stents has reduced target lesion revascularization but not mortality among all comers. Outcomes similar to that observed in recent clinical trials are being achieved in routine clinical practice.",
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AU - Singh, Mandeep

AU - Lerman, Amir

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AB - Objectives: We sought to determine the characteristics, outcomes, and temporal trends among patients undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) from a single-center registry. Background: There is controversy regarding the generalizability of the findings from randomized trials of PCI for stable CAD to daily practice. An important perspective on the significance of the trial results can be achieved by clearly documenting past and present practice of PCI. Methods: This was a retrospective analysis of 8,912 consecutive patients undergoing elective PCI from 1979 through 2006 at a tertiary referral center. Clinical, angiographic, and procedural characteristics as well as in-hospital and long-term outcomes were measured in patients grouped into 4 eras depending on the dominant interventional strategy of that time: percutaneous transluminal coronary angioplasty, early stent, bare-metal stent, and drug-eluting stent. Results: Procedural success rates have improved (81%, 92%, 96%, and 97%, respectively, p < 0.001), and in-hospital mortality has decreased significantly (1.0%, 0.8%, 0.1%, and 0.1%, respectively, p < 0.001) over time. Kaplan-Meier estimates of mortality at 4 years were 11%, 13%, 10%, and 10%, respectively (p = 0.4). The 1-year target lesion revascularization rates in the 4 groups were 29%, 26%, 13%, and 8%, respectively (p < 0.001). Conclusions: Procedural success rates in contemporary practice of PCI for stable CAD are excellent with very low in-hospital mortality. Introduction of drug-eluting stents has reduced target lesion revascularization but not mortality among all comers. Outcomes similar to that observed in recent clinical trials are being achieved in routine clinical practice.

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