Perceived Discrimination and Cardiovascular Outcomes in Older African Americans

Insights From the Jackson Heart Study

Shannon M Dunlay, Steven J. Lippmann, Melissa A. Greiner, Emily C. O'Brien, Alanna Chamberlain, Robert J. Mentz, Mario Sims

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective To assess the associations of perceived discrimination and cardiovascular (CV) outcomes in African Americans (AAs) in the Jackson Heart Study. Patients and Methods In 5085 AAs free of clinical CV disease at baseline enrolled in the Jackson Heart Study from September 26, 2000, through March 31, 2004, and followed through 2012, associations of everyday discrimination (frequency of occurrences of perceived unfair treatment) and lifetime discrimination (perceived unfair treatment in 9 life domains) with CV outcomes (all-cause mortality, incident coronary heart disease [CHD], incident stroke, and heart failure [HF] hospitalization) were examined using Cox proportional hazards regression models. Results Higher levels of everyday and lifetime discrimination were more common in participants who were younger and male and had higher education and income, lower perceived standing in the community, worse perceived health care access, and fewer comorbidities. Before adjustment, higher levels of everyday and lifetime discrimination were associated with a lower risk of all-cause mortality, incident CHD, stroke, and HF hospitalization. After adjustment for potential confounders, we found no association of everyday and lifetime discrimination with incident CHD, incident stroke, or HF hospitalization; however, a decrease in all-cause mortality with progressively higher levels of everyday discrimination persisted (hazard ratio per point increase in discrimination measure, 0.90; 95% CI, 0.82-0.99; P=.02). The unexpected association of everyday discrimination and all-cause mortality was partially mediated by perceived stress. Conclusion We found no independent association of perceived discrimination with risk of incident CV disease or HF hospitalization in this AA population. An observed paradoxical negative association of everyday discrimination and all-cause mortality was partially mediated by perceived stress.

Original languageEnglish (US)
Pages (from-to)699-709
Number of pages11
JournalMayo Clinic Proceedings
Volume92
Issue number5
DOIs
StatePublished - May 1 2017

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African Americans
Hospitalization
Heart Failure
Mortality
Coronary Disease
Stroke
Cardiovascular Diseases
Proportional Hazards Models
Comorbidity
Delivery of Health Care
Education
Therapeutics
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Perceived Discrimination and Cardiovascular Outcomes in Older African Americans : Insights From the Jackson Heart Study. / Dunlay, Shannon M; Lippmann, Steven J.; Greiner, Melissa A.; O'Brien, Emily C.; Chamberlain, Alanna; Mentz, Robert J.; Sims, Mario.

In: Mayo Clinic Proceedings, Vol. 92, No. 5, 01.05.2017, p. 699-709.

Research output: Contribution to journalArticle

Dunlay, Shannon M ; Lippmann, Steven J. ; Greiner, Melissa A. ; O'Brien, Emily C. ; Chamberlain, Alanna ; Mentz, Robert J. ; Sims, Mario. / Perceived Discrimination and Cardiovascular Outcomes in Older African Americans : Insights From the Jackson Heart Study. In: Mayo Clinic Proceedings. 2017 ; Vol. 92, No. 5. pp. 699-709.
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