Pemetrexed, carboplatin, and concomitant radiation followed by surgery for locally advanced esophageal cancer: Results of a planned interim toxicity analysis of North Central Cancer Treatment Group study N044E

Rajini Katipamula, Aminah Jatoi, Nathan R. Foster, Francis Nichols, Joseph Rubin, Matthew Callister, Leonard Gunderson, Steven Alberts

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Purpose: This brief report describes a planned, interim, 6-patient toxicity analysis that confirms the safety of pemetrexed, carboplatin, radiation with subsequent surgery, as prescribed in the North Central Cancer Treatment Group trial N044E, in patients with locally advanced esophageal cancer.

Methods: Six patients with locally advanced, potentially resectable esophageal cancer received pemetrexed 500 mg/m2 and carboplatin AUC = 6 on days 1 and 22 with 5040 centigray of concomitant radiation in 28 fractions over 5.5 weeks followed by esophagectomy as a prelude to a phase II multi-institutional trial.

Results: Only 1 of the 6 patients experienced a grade 4 adverse event (neutropenia). This patient also experienced a grade 3 depression. Of the remaining 5 patients, three experienced at least one grade 3 adverse event (neutropenia, nausea/vomiting, and esophagitis). There were no deaths. Incidentally, one patient manifested a complete pathologic response, three a partial pathologic response, and one stable disease.

Conclusion: These preliminary observations on safety suggest that this regimen can be further studied in this clinical setting.

Original languageEnglish (US)
Pages (from-to)223-225
Number of pages3
JournalClinical Medicine: Oncology
Volume2
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Oncology

Fingerprint Dive into the research topics of 'Pemetrexed, carboplatin, and concomitant radiation followed by surgery for locally advanced esophageal cancer: Results of a planned interim toxicity analysis of North Central Cancer Treatment Group study N044E'. Together they form a unique fingerprint.

  • Cite this