TY - JOUR
T1 - Patients with Sentinel Acute Pancreatitis of Alcoholic Etiology Are at Risk for Organ Failure and Pancreatic Necrosis
T2 - A Dual-Center Experience
AU - Easler, Jeffrey J.
AU - De-Madaria, Enrique
AU - Nawaz, Haq
AU - Moya-Hoyo, Neftalí
AU - Koutroumpakis, Efstratios
AU - Rey-Riveiro, Mónica
AU - Singh, Vijay P.
AU - Acevedo-Piedra, Nelly G.
AU - Whitcomb, David C.
AU - Yadav, Dhiraj
AU - Papachristou, Georgios I.
N1 - Publisher Copyright:
© 2016 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Objectives To assess the relationship between alcoholic etiology, tobacco use, and severe acute pancreatitis (AP). Methods Smoking and alcohol exposure were recorded upon admission in a cohort of patients with AP within the United States. Patients with first, "sentinel" attack of AP were identified for analysis. Associations between alcohol, smoking, and severe AP were validated in an independent cohort of patients from Spain. Results US cohort (n = 222): Thirty-five percent developed organ failure (OF), 35% pancreatic necrosis (PNec), and 7% died. OF (54% vs 33%, P = 0.03), PNec (62% vs 31%, P = 0.006), intensive care unit admission (58% vs 36%, P = 0.03), and length of stay (LOS) (20 vs 8 days, P = 0.007) were greater in alcoholic when compared to other etiologies. Spanish cohort (n = 366): Similar differences in outcomes were also found with between alcoholic and nonalcoholic etiologies: OF (24% vs 8%, P = 0.001), PNec (38% vs 14%, P < 0.001), intensive care unit admission (20% vs 3%, P < 0.001), and LOS (17 vs 11 days, P = 0.04). Multivariable analysis confirmed alcoholic etiology to be independently associated with OF and PNec in both cohorts. Conclusions Alcoholic etiology is independently associated with OF and PNec in patients with sentinel AP and is important when evaluating risk for severe disease in AP.
AB - Objectives To assess the relationship between alcoholic etiology, tobacco use, and severe acute pancreatitis (AP). Methods Smoking and alcohol exposure were recorded upon admission in a cohort of patients with AP within the United States. Patients with first, "sentinel" attack of AP were identified for analysis. Associations between alcohol, smoking, and severe AP were validated in an independent cohort of patients from Spain. Results US cohort (n = 222): Thirty-five percent developed organ failure (OF), 35% pancreatic necrosis (PNec), and 7% died. OF (54% vs 33%, P = 0.03), PNec (62% vs 31%, P = 0.006), intensive care unit admission (58% vs 36%, P = 0.03), and length of stay (LOS) (20 vs 8 days, P = 0.007) were greater in alcoholic when compared to other etiologies. Spanish cohort (n = 366): Similar differences in outcomes were also found with between alcoholic and nonalcoholic etiologies: OF (24% vs 8%, P = 0.001), PNec (38% vs 14%, P < 0.001), intensive care unit admission (20% vs 3%, P < 0.001), and LOS (17 vs 11 days, P = 0.04). Multivariable analysis confirmed alcoholic etiology to be independently associated with OF and PNec in both cohorts. Conclusions Alcoholic etiology is independently associated with OF and PNec in patients with sentinel AP and is important when evaluating risk for severe disease in AP.
KW - Acute pancreatitis
KW - Alcohol
KW - Pancreatic necrosis
KW - Tobacco
UR - http://www.scopus.com/inward/record.url?scp=84964397465&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964397465&partnerID=8YFLogxK
U2 - 10.1097/MPA.0000000000000643
DO - 10.1097/MPA.0000000000000643
M3 - Article
C2 - 27101573
AN - SCOPUS:84964397465
SN - 0885-3177
VL - 45
SP - 997
EP - 1002
JO - Pancreas
JF - Pancreas
IS - 7
ER -