Patient-reported distress and survival among patients receiving definitive radiation therapy

Yacob Habboush, Robert P. Shannon, Shehzad K. Niazi, Laeticia Hollant, Megan Single, Katherine Gaines, Bridget Smart, Nicolette T. Chimato, Michael G. Heckman, Steven J. Buskirk, Laura A. Vallow, Katherine S. Tzou, Stephen J. Ko, Jennifer L. Peterson, Heather A. Biers, Atiya B. Day, Kimberly A. Nelson, Jeff A Sloan, Michele Y. Halyard, Robert C. Miller

Research output: Contribution to journalArticle

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Abstract

Objective Patient-reported distress (PRD) has not been well assessed in association with survival after radiation therapy (RT). The aims of this study were to evaluate the association between PRD level and survival after definitive RT and to identify the main causes of distress in definitive RT patients. Methods and materials A total of 678 consecutive patients receiving definitive RT at our institution from April 2012 through May 2015 were included. All patients answered a PRD questionnaire that contained 30 items related to possible causes of distress, which could be rated from 1 (no distress) to 5 (high distress). Additionally, patients were asked to rate their overall distress level from 0 (no distress) to 10 (extreme distress). This overall distress level was our primary patient-reported distress measure and was examined as a continuous variable and as a categorical variable with 3 PRD levels (low, 0-3 [n = 295]; moderate, 4-6 [n = 222]; and high, 7-10 [n = 161]). Results As a continuous variable in multivariable Cox regression analysis, a higher overall PRD level was associated with poorer survival after RT (hazard ratio [HR], 1.39; P = .004). As a categorical variable, compared with patients with low distress, survival was poorer for patients with moderate distress (HR, 1.62; P = .038) or high distress (HR, 1.49; P = .12), but the latter difference was not significant. When the moderate and high distress levels were combined, survival was significantly poorer compared with the low distress level (HR, 1.57; P = .034). The top 5 specific causes of distress that patients mentioned were “How I feel during treatment,” “Fatigue,” “Out-of-pocket medical costs,” “Pain that affects my daily functioning,” and “Sleep difficulties.” Conclusions PRD before or during RT is a prognostic factor associated with decreased survival. Distress screening guidelines and interventions should be implemented for patients receiving definitive RT.

Original languageEnglish (US)
Pages (from-to)211-219
Number of pages9
JournalAdvances in Radiation Oncology
Volume2
Issue number2
DOIs
StatePublished - Apr 1 2017

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Radiotherapy
Survival
Health Expenditures
Fatigue
Sleep
Regression Analysis
Guidelines
Pain

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Habboush, Y., Shannon, R. P., Niazi, S. K., Hollant, L., Single, M., Gaines, K., ... Miller, R. C. (2017). Patient-reported distress and survival among patients receiving definitive radiation therapy. Advances in Radiation Oncology, 2(2), 211-219. https://doi.org/10.1016/j.adro.2017.03.004

Patient-reported distress and survival among patients receiving definitive radiation therapy. / Habboush, Yacob; Shannon, Robert P.; Niazi, Shehzad K.; Hollant, Laeticia; Single, Megan; Gaines, Katherine; Smart, Bridget; Chimato, Nicolette T.; Heckman, Michael G.; Buskirk, Steven J.; Vallow, Laura A.; Tzou, Katherine S.; Ko, Stephen J.; Peterson, Jennifer L.; Biers, Heather A.; Day, Atiya B.; Nelson, Kimberly A.; Sloan, Jeff A; Halyard, Michele Y.; Miller, Robert C.

In: Advances in Radiation Oncology, Vol. 2, No. 2, 01.04.2017, p. 211-219.

Research output: Contribution to journalArticle

Habboush, Y, Shannon, RP, Niazi, SK, Hollant, L, Single, M, Gaines, K, Smart, B, Chimato, NT, Heckman, MG, Buskirk, SJ, Vallow, LA, Tzou, KS, Ko, SJ, Peterson, JL, Biers, HA, Day, AB, Nelson, KA, Sloan, JA, Halyard, MY & Miller, RC 2017, 'Patient-reported distress and survival among patients receiving definitive radiation therapy', Advances in Radiation Oncology, vol. 2, no. 2, pp. 211-219. https://doi.org/10.1016/j.adro.2017.03.004
Habboush, Yacob ; Shannon, Robert P. ; Niazi, Shehzad K. ; Hollant, Laeticia ; Single, Megan ; Gaines, Katherine ; Smart, Bridget ; Chimato, Nicolette T. ; Heckman, Michael G. ; Buskirk, Steven J. ; Vallow, Laura A. ; Tzou, Katherine S. ; Ko, Stephen J. ; Peterson, Jennifer L. ; Biers, Heather A. ; Day, Atiya B. ; Nelson, Kimberly A. ; Sloan, Jeff A ; Halyard, Michele Y. ; Miller, Robert C. / Patient-reported distress and survival among patients receiving definitive radiation therapy. In: Advances in Radiation Oncology. 2017 ; Vol. 2, No. 2. pp. 211-219.
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abstract = "Objective Patient-reported distress (PRD) has not been well assessed in association with survival after radiation therapy (RT). The aims of this study were to evaluate the association between PRD level and survival after definitive RT and to identify the main causes of distress in definitive RT patients. Methods and materials A total of 678 consecutive patients receiving definitive RT at our institution from April 2012 through May 2015 were included. All patients answered a PRD questionnaire that contained 30 items related to possible causes of distress, which could be rated from 1 (no distress) to 5 (high distress). Additionally, patients were asked to rate their overall distress level from 0 (no distress) to 10 (extreme distress). This overall distress level was our primary patient-reported distress measure and was examined as a continuous variable and as a categorical variable with 3 PRD levels (low, 0-3 [n = 295]; moderate, 4-6 [n = 222]; and high, 7-10 [n = 161]). Results As a continuous variable in multivariable Cox regression analysis, a higher overall PRD level was associated with poorer survival after RT (hazard ratio [HR], 1.39; P = .004). As a categorical variable, compared with patients with low distress, survival was poorer for patients with moderate distress (HR, 1.62; P = .038) or high distress (HR, 1.49; P = .12), but the latter difference was not significant. When the moderate and high distress levels were combined, survival was significantly poorer compared with the low distress level (HR, 1.57; P = .034). The top 5 specific causes of distress that patients mentioned were “How I feel during treatment,” “Fatigue,” “Out-of-pocket medical costs,” “Pain that affects my daily functioning,” and “Sleep difficulties.” Conclusions PRD before or during RT is a prognostic factor associated with decreased survival. Distress screening guidelines and interventions should be implemented for patients receiving definitive RT.",
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AU - Habboush, Yacob

AU - Shannon, Robert P.

AU - Niazi, Shehzad K.

AU - Hollant, Laeticia

AU - Single, Megan

AU - Gaines, Katherine

AU - Smart, Bridget

AU - Chimato, Nicolette T.

AU - Heckman, Michael G.

AU - Buskirk, Steven J.

AU - Vallow, Laura A.

AU - Tzou, Katherine S.

AU - Ko, Stephen J.

AU - Peterson, Jennifer L.

AU - Biers, Heather A.

AU - Day, Atiya B.

AU - Nelson, Kimberly A.

AU - Sloan, Jeff A

AU - Halyard, Michele Y.

AU - Miller, Robert C.

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N2 - Objective Patient-reported distress (PRD) has not been well assessed in association with survival after radiation therapy (RT). The aims of this study were to evaluate the association between PRD level and survival after definitive RT and to identify the main causes of distress in definitive RT patients. Methods and materials A total of 678 consecutive patients receiving definitive RT at our institution from April 2012 through May 2015 were included. All patients answered a PRD questionnaire that contained 30 items related to possible causes of distress, which could be rated from 1 (no distress) to 5 (high distress). Additionally, patients were asked to rate their overall distress level from 0 (no distress) to 10 (extreme distress). This overall distress level was our primary patient-reported distress measure and was examined as a continuous variable and as a categorical variable with 3 PRD levels (low, 0-3 [n = 295]; moderate, 4-6 [n = 222]; and high, 7-10 [n = 161]). Results As a continuous variable in multivariable Cox regression analysis, a higher overall PRD level was associated with poorer survival after RT (hazard ratio [HR], 1.39; P = .004). As a categorical variable, compared with patients with low distress, survival was poorer for patients with moderate distress (HR, 1.62; P = .038) or high distress (HR, 1.49; P = .12), but the latter difference was not significant. When the moderate and high distress levels were combined, survival was significantly poorer compared with the low distress level (HR, 1.57; P = .034). The top 5 specific causes of distress that patients mentioned were “How I feel during treatment,” “Fatigue,” “Out-of-pocket medical costs,” “Pain that affects my daily functioning,” and “Sleep difficulties.” Conclusions PRD before or during RT is a prognostic factor associated with decreased survival. Distress screening guidelines and interventions should be implemented for patients receiving definitive RT.

AB - Objective Patient-reported distress (PRD) has not been well assessed in association with survival after radiation therapy (RT). The aims of this study were to evaluate the association between PRD level and survival after definitive RT and to identify the main causes of distress in definitive RT patients. Methods and materials A total of 678 consecutive patients receiving definitive RT at our institution from April 2012 through May 2015 were included. All patients answered a PRD questionnaire that contained 30 items related to possible causes of distress, which could be rated from 1 (no distress) to 5 (high distress). Additionally, patients were asked to rate their overall distress level from 0 (no distress) to 10 (extreme distress). This overall distress level was our primary patient-reported distress measure and was examined as a continuous variable and as a categorical variable with 3 PRD levels (low, 0-3 [n = 295]; moderate, 4-6 [n = 222]; and high, 7-10 [n = 161]). Results As a continuous variable in multivariable Cox regression analysis, a higher overall PRD level was associated with poorer survival after RT (hazard ratio [HR], 1.39; P = .004). As a categorical variable, compared with patients with low distress, survival was poorer for patients with moderate distress (HR, 1.62; P = .038) or high distress (HR, 1.49; P = .12), but the latter difference was not significant. When the moderate and high distress levels were combined, survival was significantly poorer compared with the low distress level (HR, 1.57; P = .034). The top 5 specific causes of distress that patients mentioned were “How I feel during treatment,” “Fatigue,” “Out-of-pocket medical costs,” “Pain that affects my daily functioning,” and “Sleep difficulties.” Conclusions PRD before or during RT is a prognostic factor associated with decreased survival. Distress screening guidelines and interventions should be implemented for patients receiving definitive RT.

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