Pathophysiology of variceal bleeding

L. R. Roberts; P. S. Kamath

doi:10.1016/s1052-5157(18)30201-0

Pathophysiology of variceal bleeding

L. R. Roberts, P. S. Kamath

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

A review of the pathophysiology of variceal bleeding, with a discussion of the pathogenesis of portal hypertension, formation of varices, and bleeding from varices. Portal hypertension results from increases in portal flow and portal vascular resistance. The factors increasing portal blood flow are primarily humoral. Resistance to portal flow has fixed and variable components. Elevated portal pressure leads to variceal formation. Variceal bleeding is dependent on portal pressure, variceal size, and variceal wall thickness.

Original language	English (US)
Pages (from-to)	167-174
Number of pages	8
Journal	Gastrointestinal Endoscopy Clinics of North America
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/s1052-5157(18)30201-0
State	Published - 1999

ASJC Scopus subject areas

Gastroenterology

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AB - A review of the pathophysiology of variceal bleeding, with a discussion of the pathogenesis of portal hypertension, formation of varices, and bleeding from varices. Portal hypertension results from increases in portal flow and portal vascular resistance. The factors increasing portal blood flow are primarily humoral. Resistance to portal flow has fixed and variable components. Elevated portal pressure leads to variceal formation. Variceal bleeding is dependent on portal pressure, variceal size, and variceal wall thickness.

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