TY - JOUR
T1 - Pathophysiology of variceal bleeding
AU - Roberts, L. R.
AU - Kamath, P. S.
PY - 1999
Y1 - 1999
N2 - A review of the pathophysiology of variceal bleeding, with a discussion of the pathogenesis of portal hypertension, formation of varices, and bleeding from varices. Portal hypertension results from increases in portal flow and portal vascular resistance. The factors increasing portal blood flow are primarily humoral. Resistance to portal flow has fixed and variable components. Elevated portal pressure leads to variceal formation. Variceal bleeding is dependent on portal pressure, variceal size, and variceal wall thickness.
AB - A review of the pathophysiology of variceal bleeding, with a discussion of the pathogenesis of portal hypertension, formation of varices, and bleeding from varices. Portal hypertension results from increases in portal flow and portal vascular resistance. The factors increasing portal blood flow are primarily humoral. Resistance to portal flow has fixed and variable components. Elevated portal pressure leads to variceal formation. Variceal bleeding is dependent on portal pressure, variceal size, and variceal wall thickness.
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U2 - 10.1016/s1052-5157(18)30201-0
DO - 10.1016/s1052-5157(18)30201-0
M3 - Review article
C2 - 10333436
AN - SCOPUS:0033046445
VL - 9
SP - 167
EP - 174
JO - Gastrointestinal Endoscopy Clinics of North America
JF - Gastrointestinal Endoscopy Clinics of North America
SN - 1052-5157
IS - 2
ER -