Pathology of the thyroid in amiodarone-associated thyrotoxicosis

Thomas Christopher Smyrk, J. R. Goellner, M. D. Brennan, J. A. Carney

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Among 83 consecutive patients operated on for thyrotoxicosis at the Mayo Clinic between January 1, 1980 and May 1, 1986, four had a combination of pathologic findings that were similar and unexpected: involutional changes; degnerative and destructive follicular lesions; and zones of fibrosis. These four, but none of the remaining 79, were being treated with amiodarone for cardiac tachyarrhythmias; this drug is known to be taken up by the thyroid gland. Characteristically, small groups of involuted follicles exhibited varying degrees of damage ranging from degenerative changes in a few lining cells to total follicular destruction. Damaged follicular cells were swollen and featured granular or vacuolated cytoplasm. This type of cytoplasmic alteration has been reported to occur in pneumocytes and hepatocytes damaged by amiodarone. Therefore, the drug probably is the cause of the thyroid cell damage, and follicular disruption (with consequent release of iodothyronines into the circulation) is likely to be an important contributor to the associated thyrotoxicosis.

Original languageEnglish (US)
Pages (from-to)197-204
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume11
Issue number3
StatePublished - 1987

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Thyrotoxicosis
Amiodarone
Thyroid Gland
Pathology
Alveolar Epithelial Cells
Tachycardia
Pharmaceutical Preparations
Hepatocytes
Cytoplasm
Fibrosis
Thyroid Epithelial Cells

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Smyrk, T. C., Goellner, J. R., Brennan, M. D., & Carney, J. A. (1987). Pathology of the thyroid in amiodarone-associated thyrotoxicosis. American Journal of Surgical Pathology, 11(3), 197-204.

Pathology of the thyroid in amiodarone-associated thyrotoxicosis. / Smyrk, Thomas Christopher; Goellner, J. R.; Brennan, M. D.; Carney, J. A.

In: American Journal of Surgical Pathology, Vol. 11, No. 3, 1987, p. 197-204.

Research output: Contribution to journalArticle

Smyrk, TC, Goellner, JR, Brennan, MD & Carney, JA 1987, 'Pathology of the thyroid in amiodarone-associated thyrotoxicosis', American Journal of Surgical Pathology, vol. 11, no. 3, pp. 197-204.
Smyrk TC, Goellner JR, Brennan MD, Carney JA. Pathology of the thyroid in amiodarone-associated thyrotoxicosis. American Journal of Surgical Pathology. 1987;11(3):197-204.
Smyrk, Thomas Christopher ; Goellner, J. R. ; Brennan, M. D. ; Carney, J. A. / Pathology of the thyroid in amiodarone-associated thyrotoxicosis. In: American Journal of Surgical Pathology. 1987 ; Vol. 11, No. 3. pp. 197-204.
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