Pathology of the liver sinusoids

Elizabeth M. Brunt, Annette S.H. Gouw, Stefan G. Hubscher, Dina G. Tiniakos, Pierre Bedossa, Alastair D. Burt, Francesco Callea, Andrew D. Clouston, Hans P. Dienes, Zachary D. Goodman, Eve A. Roberts, Tania Roskams, Luigi Terracciano, Michael Torbenson, Ian R. Wanless

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

The hepatic sinusoids comprise a complex of vascular conduits to transport blood from the porta hepatis to the inferior vena cava through the liver. Under normal conditions, portal venous and hepatic artery pressures are equalized within the sinusoids, oxygen and nutrients from the systemic circulation are delivered to the parenchymal cells and differentially distributed throughout the liver acini, and proteins of liver derivation are carried into the cardiac/systemic circulation. Liver sinusoid structures are lined by endothelial cells unique to their location, and Kupffer cells. Multifunctional hepatic stellate cells and various immune active cells are localized within the space of Disse between the sinusoid and the adjacent hepatocytes. Flow within the sinusoids can be compromised by physical or pressure blockage in their lumina as well as obstructive processes within the space of Disse. The intimate relationship of the liver sinusoids to neighbouring hepatocytes is a significant factor affecting the health of hepatocytes, or transmission of the effects of injury within the sinusoidal space. Pathologists should recognize several patterns of injury involving the sinusoids and surrounding hepatocytes. In this review, injury, alterations and accumulations within the liver sinusoids are illustrated and discussed.

Original languageEnglish (US)
Pages (from-to)907-920
Number of pages14
JournalHistopathology
Volume64
Issue number7
DOIs
StatePublished - Jan 1 2014

Fingerprint

Pathology
Liver
Hepatocytes
Wounds and Injuries
Pressure
Hepatic Stellate Cells
Kupffer Cells
Hepatic Artery
Inferior Vena Cava
Blood Vessels
Endothelial Cells
Oxygen
Food
Health
Proteins

Keywords

  • Capillarization
  • Endothelial cells
  • Kupffer cells
  • Liver sinusoids
  • Space of Disse

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Brunt, E. M., Gouw, A. S. H., Hubscher, S. G., Tiniakos, D. G., Bedossa, P., Burt, A. D., ... Wanless, I. R. (2014). Pathology of the liver sinusoids. Histopathology, 64(7), 907-920. https://doi.org/10.1111/his.12364

Pathology of the liver sinusoids. / Brunt, Elizabeth M.; Gouw, Annette S.H.; Hubscher, Stefan G.; Tiniakos, Dina G.; Bedossa, Pierre; Burt, Alastair D.; Callea, Francesco; Clouston, Andrew D.; Dienes, Hans P.; Goodman, Zachary D.; Roberts, Eve A.; Roskams, Tania; Terracciano, Luigi; Torbenson, Michael; Wanless, Ian R.

In: Histopathology, Vol. 64, No. 7, 01.01.2014, p. 907-920.

Research output: Contribution to journalReview article

Brunt, EM, Gouw, ASH, Hubscher, SG, Tiniakos, DG, Bedossa, P, Burt, AD, Callea, F, Clouston, AD, Dienes, HP, Goodman, ZD, Roberts, EA, Roskams, T, Terracciano, L, Torbenson, M & Wanless, IR 2014, 'Pathology of the liver sinusoids', Histopathology, vol. 64, no. 7, pp. 907-920. https://doi.org/10.1111/his.12364
Brunt EM, Gouw ASH, Hubscher SG, Tiniakos DG, Bedossa P, Burt AD et al. Pathology of the liver sinusoids. Histopathology. 2014 Jan 1;64(7):907-920. https://doi.org/10.1111/his.12364
Brunt, Elizabeth M. ; Gouw, Annette S.H. ; Hubscher, Stefan G. ; Tiniakos, Dina G. ; Bedossa, Pierre ; Burt, Alastair D. ; Callea, Francesco ; Clouston, Andrew D. ; Dienes, Hans P. ; Goodman, Zachary D. ; Roberts, Eve A. ; Roskams, Tania ; Terracciano, Luigi ; Torbenson, Michael ; Wanless, Ian R. / Pathology of the liver sinusoids. In: Histopathology. 2014 ; Vol. 64, No. 7. pp. 907-920.
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