Pathogenesis of Graves' ophthalmopathy: The role of autoantibodies

Teck Kim Khoo, Rebecca S. Bahn

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

The clinical manifestations of Graves' ophthalmopathy (GO) stem from a combination of increased orbital fat and extraocular muscle volume within the orbital space. Fibroblasts residing within orbital tissues are thought to be targets of autoimmune attack in the disease. Thyrotropin receptor (TSHr) mRNA and functional protein have been demonstrated in orbital fibroblasts from both normal individuals and GO patients, with higher levels present in the latter. Autoantibodies directed against TSHr or the insulin-like growth factor-1 (IGF-1) receptor have been implicated in GO pathogenesis. Evidence from our laboratory suggests that monoclonal TSHr autoantibodies (TRAbs) are potent stimulators of adipogenesis in GO orbital cells. Therefore, it is possible that circulating TRAbs in Graves' patients both stimulate overproduction of thyroid hormones and increase orbital adipose tissue volume. Antibodies to the IGF-1 receptor appear to impact GO pathogenesis through recruitment and activation of T-cells and stimulation of hyaluronan production, processes that play key roles in the development of inflammation and increased orbital tissue swelling. Although originally thought to represent another causative agent, antibodies to extraocular muscles are now generally thought to be secondary to extraocular muscle inflammation and damage.

Original languageEnglish (US)
Pages (from-to)1013-1018
Number of pages6
JournalThyroid
Volume17
Issue number10
DOIs
StatePublished - Oct 1 2007

Fingerprint

Graves Ophthalmopathy
Oculomotor Muscles
Autoantibodies
Somatomedin Receptors
Fibroblasts
Inflammation
Thyrotropin Receptors
Adipogenesis
Antibodies
Hyaluronic Acid
Thyroid Hormones
Adipose Tissue
Fats
T-Lymphocytes
Messenger RNA
Proteins

ASJC Scopus subject areas

  • Endocrinology

Cite this

Pathogenesis of Graves' ophthalmopathy : The role of autoantibodies. / Khoo, Teck Kim; Bahn, Rebecca S.

In: Thyroid, Vol. 17, No. 10, 01.10.2007, p. 1013-1018.

Research output: Contribution to journalArticle

Khoo, Teck Kim ; Bahn, Rebecca S. / Pathogenesis of Graves' ophthalmopathy : The role of autoantibodies. In: Thyroid. 2007 ; Vol. 17, No. 10. pp. 1013-1018.
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