Partial characterization of the Purkinje cell antigens in paraneoplastic cerebellar degeneration

Julie M Cunningham, F. Graus, N. Anderson, J. B. Posner

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Serum from seven patients with paraneoplastic cerebellar degeneration contained anti-Purkinje cell antibodies. The samples were examined by immunoblotting to determine whether they recognized common antigens in isolated human Purkinje cell neurons. Two groups of antigens were detected by all seven sera with Mr 62/64 kd and 34 to 38 kd, both of which contributed to the Purkinje cell antigens detected immunohistochemically. These reactivities were absent from all controls tested. These antibodies may play a role in the pathogenesis of paraneoplastic cerebellar degeneration.

Original languageEnglish (US)
Pages (from-to)1163-1168
Number of pages6
JournalNeurology
Volume36
Issue number9
StatePublished - 1986
Externally publishedYes

Fingerprint

Paraneoplastic Cerebellar Degeneration
Purkinje Cells
Antigens
Antibodies
Serum
Immunoblotting

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Partial characterization of the Purkinje cell antigens in paraneoplastic cerebellar degeneration. / Cunningham, Julie M; Graus, F.; Anderson, N.; Posner, J. B.

In: Neurology, Vol. 36, No. 9, 1986, p. 1163-1168.

Research output: Contribution to journalArticle

Cunningham, Julie M ; Graus, F. ; Anderson, N. ; Posner, J. B. / Partial characterization of the Purkinje cell antigens in paraneoplastic cerebellar degeneration. In: Neurology. 1986 ; Vol. 36, No. 9. pp. 1163-1168.
@article{3cadc21b295141bfbd470b3523ce27fa,
title = "Partial characterization of the Purkinje cell antigens in paraneoplastic cerebellar degeneration",
abstract = "Serum from seven patients with paraneoplastic cerebellar degeneration contained anti-Purkinje cell antibodies. The samples were examined by immunoblotting to determine whether they recognized common antigens in isolated human Purkinje cell neurons. Two groups of antigens were detected by all seven sera with Mr 62/64 kd and 34 to 38 kd, both of which contributed to the Purkinje cell antigens detected immunohistochemically. These reactivities were absent from all controls tested. These antibodies may play a role in the pathogenesis of paraneoplastic cerebellar degeneration.",
author = "Cunningham, {Julie M} and F. Graus and N. Anderson and Posner, {J. B.}",
year = "1986",
language = "English (US)",
volume = "36",
pages = "1163--1168",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Partial characterization of the Purkinje cell antigens in paraneoplastic cerebellar degeneration

AU - Cunningham, Julie M

AU - Graus, F.

AU - Anderson, N.

AU - Posner, J. B.

PY - 1986

Y1 - 1986

N2 - Serum from seven patients with paraneoplastic cerebellar degeneration contained anti-Purkinje cell antibodies. The samples were examined by immunoblotting to determine whether they recognized common antigens in isolated human Purkinje cell neurons. Two groups of antigens were detected by all seven sera with Mr 62/64 kd and 34 to 38 kd, both of which contributed to the Purkinje cell antigens detected immunohistochemically. These reactivities were absent from all controls tested. These antibodies may play a role in the pathogenesis of paraneoplastic cerebellar degeneration.

AB - Serum from seven patients with paraneoplastic cerebellar degeneration contained anti-Purkinje cell antibodies. The samples were examined by immunoblotting to determine whether they recognized common antigens in isolated human Purkinje cell neurons. Two groups of antigens were detected by all seven sera with Mr 62/64 kd and 34 to 38 kd, both of which contributed to the Purkinje cell antigens detected immunohistochemically. These reactivities were absent from all controls tested. These antibodies may play a role in the pathogenesis of paraneoplastic cerebellar degeneration.

UR - http://www.scopus.com/inward/record.url?scp=0022543286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022543286&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 1163

EP - 1168

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 9

ER -