Paromomycin-associated pancreatitis in HIV-related cryptosporidiosis

W. W. Tan; E. K. Chapnick; E. I.M. Abter; S. Haddad; E. H. Zimbalist; L. I. Lutwick

doi:10.1177/106002809502900104

Paromomycin-associated pancreatitis in HIV-related cryptosporidiosis

W. W. Tan, E. K. Chapnick, E. I.M. Abter, S. Haddad, E. H. Zimbalist, L. I. Lutwick

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

OBJECTIVE: To report a case of pancreatitis related to paromomycin administration. CASE SUMMARY: A 39-year-old man with AIDS developed pancreatitis concurrent with successful treatment of intestinal cryptosporidiosis with paromomycin. The hyperamylasemia resolved with discontinuation of the agent and recurred when paromomycin treatment was reinstituted. DISCUSSION: To our knowledge, this is the first reported case of pancreatitis believed to be induced by paromomycin. Although pancreatitis in HIV-infected patients has multiple causes, the nature of this case suggests the involvement of paromomycin. The mechanism of action is unclear. CONCLUSIONS: Pancreatitis should be considered in the differential diagnosis of abdominal pain in patients who are treated with paromomycin.

Original language	English (US)
Pages (from-to)	22-24
Number of pages	3
Journal	Annals of Pharmacotherapy
Volume	29
Issue number	1
DOIs	https://doi.org/10.1177/106002809502900104
State	Published - 1995

ASJC Scopus subject areas

Pharmacology (medical)

Access to Document

10.1177/106002809502900104

Cite this

@article{48668bc7f3964ffdb999897f2e6a264e,

title = "Paromomycin-associated pancreatitis in HIV-related cryptosporidiosis",

abstract = "OBJECTIVE: To report a case of pancreatitis related to paromomycin administration. CASE SUMMARY: A 39-year-old man with AIDS developed pancreatitis concurrent with successful treatment of intestinal cryptosporidiosis with paromomycin. The hyperamylasemia resolved with discontinuation of the agent and recurred when paromomycin treatment was reinstituted. DISCUSSION: To our knowledge, this is the first reported case of pancreatitis believed to be induced by paromomycin. Although pancreatitis in HIV-infected patients has multiple causes, the nature of this case suggests the involvement of paromomycin. The mechanism of action is unclear. CONCLUSIONS: Pancreatitis should be considered in the differential diagnosis of abdominal pain in patients who are treated with paromomycin.",

author = "Tan, {W. W.} and Chapnick, {E. K.} and Abter, {E. I.M.} and S. Haddad and Zimbalist, {E. H.} and Lutwick, {L. I.}",

year = "1995",

doi = "10.1177/106002809502900104",

language = "English (US)",

volume = "29",

pages = "22--24",

journal = "Annals of Pharmacotherapy",

issn = "1060-0280",

publisher = "Harvey Whitney Books Company",

number = "1",

}

TY - JOUR

T1 - Paromomycin-associated pancreatitis in HIV-related cryptosporidiosis

AU - Tan, W. W.

AU - Chapnick, E. K.

AU - Abter, E. I.M.

AU - Haddad, S.

AU - Zimbalist, E. H.

AU - Lutwick, L. I.

PY - 1995

Y1 - 1995

N2 - OBJECTIVE: To report a case of pancreatitis related to paromomycin administration. CASE SUMMARY: A 39-year-old man with AIDS developed pancreatitis concurrent with successful treatment of intestinal cryptosporidiosis with paromomycin. The hyperamylasemia resolved with discontinuation of the agent and recurred when paromomycin treatment was reinstituted. DISCUSSION: To our knowledge, this is the first reported case of pancreatitis believed to be induced by paromomycin. Although pancreatitis in HIV-infected patients has multiple causes, the nature of this case suggests the involvement of paromomycin. The mechanism of action is unclear. CONCLUSIONS: Pancreatitis should be considered in the differential diagnosis of abdominal pain in patients who are treated with paromomycin.

AB - OBJECTIVE: To report a case of pancreatitis related to paromomycin administration. CASE SUMMARY: A 39-year-old man with AIDS developed pancreatitis concurrent with successful treatment of intestinal cryptosporidiosis with paromomycin. The hyperamylasemia resolved with discontinuation of the agent and recurred when paromomycin treatment was reinstituted. DISCUSSION: To our knowledge, this is the first reported case of pancreatitis believed to be induced by paromomycin. Although pancreatitis in HIV-infected patients has multiple causes, the nature of this case suggests the involvement of paromomycin. The mechanism of action is unclear. CONCLUSIONS: Pancreatitis should be considered in the differential diagnosis of abdominal pain in patients who are treated with paromomycin.

UR - http://www.scopus.com/inward/record.url?scp=0028833169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028833169&partnerID=8YFLogxK

U2 - 10.1177/106002809502900104

DO - 10.1177/106002809502900104

M3 - Article

C2 - 7711341

AN - SCOPUS:0028833169

SN - 1060-0280

VL - 29

SP - 22

EP - 24

JO - Annals of Pharmacotherapy

JF - Annals of Pharmacotherapy

IS - 1

ER -

Paromomycin-associated pancreatitis in HIV-related cryptosporidiosis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this