Parkinsonism and neurofibrillary tangle pathology in pigmented nuclei

A. H. Rajput, R. J. Uitti, S. Sudhakar, B. Rozdilsky

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Four parkinsonian patients had neurofibrillary tangles, neuronal loss, and gliosis restricted to the substantia nigra and locus ceruleus. No Lewy body inclusions or other neuropathologial changes accounting for parkinsonism were found in any of these patients. Their clinical features were characterized by an early age of onset, absence of dementia, absence of other neurological abnormalities, good response to drug therapy, and a long, slowly progressive course of illness. None of the patients had any history of encephalitis. These patients either represent a forme fruste of postencephalitic parkinsonism or a new entity thus far not described.

Original languageEnglish (US)
Pages (from-to)602-606
Number of pages5
JournalAnnals of Neurology
Volume25
Issue number6
StatePublished - 1989
Externally publishedYes

Fingerprint

Neurofibrillary Tangles
Parkinsonian Disorders
Pathology
Postencephalitic Parkinson Disease
Lewy Bodies
Gliosis
Locus Coeruleus
Substantia Nigra
Encephalitis
Age of Onset
Dementia
Drug Therapy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rajput, A. H., Uitti, R. J., Sudhakar, S., & Rozdilsky, B. (1989). Parkinsonism and neurofibrillary tangle pathology in pigmented nuclei. Annals of Neurology, 25(6), 602-606.

Parkinsonism and neurofibrillary tangle pathology in pigmented nuclei. / Rajput, A. H.; Uitti, R. J.; Sudhakar, S.; Rozdilsky, B.

In: Annals of Neurology, Vol. 25, No. 6, 1989, p. 602-606.

Research output: Contribution to journalArticle

Rajput, AH, Uitti, RJ, Sudhakar, S & Rozdilsky, B 1989, 'Parkinsonism and neurofibrillary tangle pathology in pigmented nuclei', Annals of Neurology, vol. 25, no. 6, pp. 602-606.
Rajput AH, Uitti RJ, Sudhakar S, Rozdilsky B. Parkinsonism and neurofibrillary tangle pathology in pigmented nuclei. Annals of Neurology. 1989;25(6):602-606.
Rajput, A. H. ; Uitti, R. J. ; Sudhakar, S. ; Rozdilsky, B. / Parkinsonism and neurofibrillary tangle pathology in pigmented nuclei. In: Annals of Neurology. 1989 ; Vol. 25, No. 6. pp. 602-606.
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