Parkinson plus syndrome

Diagnosis using high field MR imaging of brain iron

B. P. Drayer, W. Olanow, P. Burger, G. A. Johnson, R. Herfkens, Stephen J Riederer

Research output: Contribution to journalArticle

212 Citations (Scopus)

Abstract

The distribution of iron in the brain was analyzed using high field strength (1.5 T) magnetic resonance (MR) imaging in 14 healthy control individuals and six patients with Parkinson plus syndromes (multisystem atrophy and progressive supranuclear palsy) who were unresponsive to antiparkinsonian therapy. The normal topographic distribution of iron in the brain as indicated by high field MR images coincided precisely with the distribution of iron in the brain as determined by Perls staining for ferric iron. In Parkinson plus syndromes, there were abnormally increased concentrations of iron (decreased T2 relaxation times) in the putamen, and less prominent increases in the caudate nucleus and lateral pars compacta of the substantia nigra. In high field strength MR images of normal patients, the decreased signal intensity in the globus pallidus is more prominent than that of the putamen. In MR images of patients with Parkinson plus syndromes, the decreased signal intensity of the putamen is more prominent than that of the globus pallidus.

Original languageEnglish (US)
Pages (from-to)493-498
Number of pages6
JournalRadiology
Volume159
Issue number2
StatePublished - 1986
Externally publishedYes

Fingerprint

Iron
Magnetic Resonance Imaging
Putamen
Brain
Globus Pallidus
Magnetic Resonance Spectroscopy
Antiparkinson Agents
Progressive Supranuclear Palsy
Multiple System Atrophy
Caudate Nucleus
Normal Distribution
Staining and Labeling
Therapeutics

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Drayer, B. P., Olanow, W., Burger, P., Johnson, G. A., Herfkens, R., & Riederer, S. J. (1986). Parkinson plus syndrome: Diagnosis using high field MR imaging of brain iron. Radiology, 159(2), 493-498.

Parkinson plus syndrome : Diagnosis using high field MR imaging of brain iron. / Drayer, B. P.; Olanow, W.; Burger, P.; Johnson, G. A.; Herfkens, R.; Riederer, Stephen J.

In: Radiology, Vol. 159, No. 2, 1986, p. 493-498.

Research output: Contribution to journalArticle

Drayer, BP, Olanow, W, Burger, P, Johnson, GA, Herfkens, R & Riederer, SJ 1986, 'Parkinson plus syndrome: Diagnosis using high field MR imaging of brain iron', Radiology, vol. 159, no. 2, pp. 493-498.
Drayer BP, Olanow W, Burger P, Johnson GA, Herfkens R, Riederer SJ. Parkinson plus syndrome: Diagnosis using high field MR imaging of brain iron. Radiology. 1986;159(2):493-498.
Drayer, B. P. ; Olanow, W. ; Burger, P. ; Johnson, G. A. ; Herfkens, R. ; Riederer, Stephen J. / Parkinson plus syndrome : Diagnosis using high field MR imaging of brain iron. In: Radiology. 1986 ; Vol. 159, No. 2. pp. 493-498.
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