Parathyroid carcinoma: 50-year experience at The Cleveland Clinic Foundation.

Albert Hakaim, C. B. Esselstyn

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

BACKGROUND: Parathyroid carcinoma is rare, with a reported prevalence of 0.6% to 4.0% in patients presumed to have primary hyperparathyroidism. This study examines the long-term results of surgical therapy and combination chemotherapy. PATIENTS: From 1938 to 1988, 1260 operations for primary hyperparathyroidism were performed; only six patients (0.47%) were subsequently found to have parathyroid carcinoma. A seventh patient was referred to our institution after the diagnosis of parathyroid carcinoma had been made. RESULTS: All patients had excessive hypercalcemia (serum calcium concentration > 12.0 mg/dL) with a range of 12.3 to 18.3 mg/dL. Locally recurrent tumors causing recurrent hypercalcemia were managed by repeated neck exploration and tumor resection. Six of the seven patients (85%) survived 5 years, while four patients (57%) survived 10 years. CONCLUSIONS: Diagnosis of parathyroid carcinoma rests upon postoperative surveillance of patients who have undergone previous neck exploration and resection of apparently benign adenomas. Long-term survival is possible with repeated resection of locally recurrent tumors.

Original languageEnglish (US)
Pages (from-to)331-335
Number of pages5
JournalCleveland Clinic Journal of Medicine
Volume60
Issue number4
StatePublished - Jul 1993
Externally publishedYes

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Parathyroid Neoplasms
Primary Hyperparathyroidism
Hypercalcemia
Neck
Neoplasms
Combination Drug Therapy
Adenoma
Calcium
Survival
Serum

ASJC Scopus subject areas

  • Medicine(all)

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Parathyroid carcinoma : 50-year experience at The Cleveland Clinic Foundation. / Hakaim, Albert; Esselstyn, C. B.

In: Cleveland Clinic Journal of Medicine, Vol. 60, No. 4, 07.1993, p. 331-335.

Research output: Contribution to journalArticle

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