Paraneoplastic neuromyelitis optica spectrum disorder associated with metastatic carcinoid expressing aquaporin-4

Michelle Figueroa, Yong Guo, Alexandros Tselis, Sean J Pittock, Vanda A Lennon, Claudia F Lucchinetti, Robert P. Lisak

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

IMPORTANCE: Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunitymay in some cases have a paraneoplastic basis. OBSERVATIONS: In this case report, we describe a patient with NMOSD whose test results were seropositive for aquaporin-4 IgG and who had a hepatic metastasis from a small-bowel neuroendocrine tumor. The tumor cells expressed aquaporin-4 immunoreactivity. She presented to the Neurology Department atWayne State University with bilateral leg weakness, ascending paresthesias, and decreased sensation. CONCLUSIONS AND RELEVANCE: This case extends the context of NMOSD as a paraneoplastic disorder.

Original languageEnglish (US)
Pages (from-to)495-498
Number of pages4
JournalJAMA Neurology
Volume71
Issue number4
DOIs
StatePublished - 2014

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Aquaporin 4
Neuromyelitis Optica
Carcinoid Tumor
Neuroendocrine Tumors
Paresthesia
Neurology
Neoplasms
Leg
Immunoglobulin G
Neoplasm Metastasis
Liver

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Paraneoplastic neuromyelitis optica spectrum disorder associated with metastatic carcinoid expressing aquaporin-4. / Figueroa, Michelle; Guo, Yong; Tselis, Alexandros; Pittock, Sean J; Lennon, Vanda A; Lucchinetti, Claudia F; Lisak, Robert P.

In: JAMA Neurology, Vol. 71, No. 4, 2014, p. 495-498.

Research output: Contribution to journalArticle

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AU - Figueroa, Michelle

AU - Guo, Yong

AU - Tselis, Alexandros

AU - Pittock, Sean J

AU - Lennon, Vanda A

AU - Lucchinetti, Claudia F

AU - Lisak, Robert P.

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AB - IMPORTANCE: Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunitymay in some cases have a paraneoplastic basis. OBSERVATIONS: In this case report, we describe a patient with NMOSD whose test results were seropositive for aquaporin-4 IgG and who had a hepatic metastasis from a small-bowel neuroendocrine tumor. The tumor cells expressed aquaporin-4 immunoreactivity. She presented to the Neurology Department atWayne State University with bilateral leg weakness, ascending paresthesias, and decreased sensation. CONCLUSIONS AND RELEVANCE: This case extends the context of NMOSD as a paraneoplastic disorder.

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