Paraneoplastic neuromyelitis optica spectrum disorder associated with metastatic carcinoid expressing aquaporin-4

Michelle Figueroa, Yong Guo, Alexandros Tselis, Sean J. Pittock, Vanda A. Lennon, Claudia F. Lucchinetti, Robert P. Lisak

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

IMPORTANCE: Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunitymay in some cases have a paraneoplastic basis. OBSERVATIONS: In this case report, we describe a patient with NMOSD whose test results were seropositive for aquaporin-4 IgG and who had a hepatic metastasis from a small-bowel neuroendocrine tumor. The tumor cells expressed aquaporin-4 immunoreactivity. She presented to the Neurology Department atWayne State University with bilateral leg weakness, ascending paresthesias, and decreased sensation. CONCLUSIONS AND RELEVANCE: This case extends the context of NMOSD as a paraneoplastic disorder.

Original languageEnglish (US)
Pages (from-to)495-498
Number of pages4
JournalJAMA neurology
Volume71
Issue number4
DOIs
StatePublished - Apr 2014

ASJC Scopus subject areas

  • Clinical Neurology

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