Paradigm shifts in atherosclerotic renovascular disease

Where are we now?

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Results of recent clinical trials and experimental studies indicate that whereas atherosclerotic renovascular disease can accelerate both systemic hypertension and tissue injury in the poststenotic kidney, restoring vessel patency alone is insufficient to recover kidney function formost subjects. Kidney injury in atherosclerotic renovascular disease reflects complex interactions among vascular rarefication, oxidative stress injury, and recruitment of inflammatory cellular elements that ultimately produce fibrosis. Classic paradigms for simply restoring blood flow are shifting to implementation of therapy targeting mitochondria and cell-based functions to allow regeneration of vascular, glomerular, and tubular structures sufficient to recover, or at least stabilize, renal function. These developments offer exciting possibilities of repair and regeneration of kidney tissue thatmaylimit progressiveCKDin atherosclerotic renovascular disease and may apply to other conditions in which inflammatory injury is amajor common pathway.

Original languageEnglish (US)
Pages (from-to)2074-2080
Number of pages7
JournalJournal of the American Society of Nephrology
Volume26
Issue number9
DOIs
StatePublished - Sep 1 2015

Fingerprint

Kidney
Wounds and Injuries
Blood Vessels
Regeneration
Mitochondria
Oxidative Stress
Fibrosis
Clinical Trials
Hypertension
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Paradigm shifts in atherosclerotic renovascular disease : Where are we now? / Textor, Stephen C; Lerman, Lilach O.

In: Journal of the American Society of Nephrology, Vol. 26, No. 9, 01.09.2015, p. 2074-2080.

Research output: Contribution to journalArticle

@article{5ba8582cf93343ee83e9202c480cdd22,
title = "Paradigm shifts in atherosclerotic renovascular disease: Where are we now?",
abstract = "Results of recent clinical trials and experimental studies indicate that whereas atherosclerotic renovascular disease can accelerate both systemic hypertension and tissue injury in the poststenotic kidney, restoring vessel patency alone is insufficient to recover kidney function formost subjects. Kidney injury in atherosclerotic renovascular disease reflects complex interactions among vascular rarefication, oxidative stress injury, and recruitment of inflammatory cellular elements that ultimately produce fibrosis. Classic paradigms for simply restoring blood flow are shifting to implementation of therapy targeting mitochondria and cell-based functions to allow regeneration of vascular, glomerular, and tubular structures sufficient to recover, or at least stabilize, renal function. These developments offer exciting possibilities of repair and regeneration of kidney tissue thatmaylimit progressiveCKDin atherosclerotic renovascular disease and may apply to other conditions in which inflammatory injury is amajor common pathway.",
author = "Textor, {Stephen C} and Lerman, {Lilach O}",
year = "2015",
month = "9",
day = "1",
doi = "10.1681/ASN.2014121274",
language = "English (US)",
volume = "26",
pages = "2074--2080",
journal = "Journal of the American Society of Nephrology : JASN",
issn = "1046-6673",
publisher = "American Society of Nephrology",
number = "9",

}

TY - JOUR

T1 - Paradigm shifts in atherosclerotic renovascular disease

T2 - Where are we now?

AU - Textor, Stephen C

AU - Lerman, Lilach O

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Results of recent clinical trials and experimental studies indicate that whereas atherosclerotic renovascular disease can accelerate both systemic hypertension and tissue injury in the poststenotic kidney, restoring vessel patency alone is insufficient to recover kidney function formost subjects. Kidney injury in atherosclerotic renovascular disease reflects complex interactions among vascular rarefication, oxidative stress injury, and recruitment of inflammatory cellular elements that ultimately produce fibrosis. Classic paradigms for simply restoring blood flow are shifting to implementation of therapy targeting mitochondria and cell-based functions to allow regeneration of vascular, glomerular, and tubular structures sufficient to recover, or at least stabilize, renal function. These developments offer exciting possibilities of repair and regeneration of kidney tissue thatmaylimit progressiveCKDin atherosclerotic renovascular disease and may apply to other conditions in which inflammatory injury is amajor common pathway.

AB - Results of recent clinical trials and experimental studies indicate that whereas atherosclerotic renovascular disease can accelerate both systemic hypertension and tissue injury in the poststenotic kidney, restoring vessel patency alone is insufficient to recover kidney function formost subjects. Kidney injury in atherosclerotic renovascular disease reflects complex interactions among vascular rarefication, oxidative stress injury, and recruitment of inflammatory cellular elements that ultimately produce fibrosis. Classic paradigms for simply restoring blood flow are shifting to implementation of therapy targeting mitochondria and cell-based functions to allow regeneration of vascular, glomerular, and tubular structures sufficient to recover, or at least stabilize, renal function. These developments offer exciting possibilities of repair and regeneration of kidney tissue thatmaylimit progressiveCKDin atherosclerotic renovascular disease and may apply to other conditions in which inflammatory injury is amajor common pathway.

UR - http://www.scopus.com/inward/record.url?scp=84940752624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940752624&partnerID=8YFLogxK

U2 - 10.1681/ASN.2014121274

DO - 10.1681/ASN.2014121274

M3 - Article

VL - 26

SP - 2074

EP - 2080

JO - Journal of the American Society of Nephrology : JASN

JF - Journal of the American Society of Nephrology : JASN

SN - 1046-6673

IS - 9

ER -