Pancreatic Disorders in Patients with Inflammatory Bowel Disease

Marilia L. Montenegro; Juan E. Corral; Frank J. Lukens; Baoan Ji; Paul T. Kröner; Francis A. Farraye; Yan Bi

doi:10.1007/s10620-021-06899-2

Pancreatic Disorders in Patients with Inflammatory Bowel Disease

Marilia L. Montenegro, Juan E. Corral, Frank J. Lukens, Baoan Ji, Paul T. Kröner, Francis A. Farraye, Yan Bi

Research output: Contribution to journal › Review article › peer-review

Abstract

Inflammatory bowel disease (IBD) can involve multiple organ systems, and pancreatic manifestations of IBD are not uncommon. The incidence of several pancreatic diseases is more frequent in patients with Crohn’s disease and ulcerative colitis than in the general population. Pancreatic manifestations in IBD include a heterogeneous group of disorders and abnormalities ranging from mild, self-limited disorders to severe diseases. Asymptomatic elevation of amylase and/or lipase is common. The risk of acute pancreatitis in patients with IBD is increased due to the higher incidence of cholelithiasis and drug-induced pancreatitis in this population. Patients with IBD commonly have altered pancreatic histology and chronic pancreatic exocrine dysfunction. Diagnosing acute pancreatitis in patients with IBD is challenging. In this review, we discuss the manifestations and possible causes of pancreatic abnormalities in patients with IBD.

Original language	English (US)
Pages (from-to)	423-436
Number of pages	14
Journal	Digestive diseases and sciences
Volume	67
Issue number	2
DOIs	https://doi.org/10.1007/s10620-021-06899-2
State	Published - Feb 2022

Keywords

Crohn’s disease
Extraintestinal manifestations
Inflammatory bowel disease
Pancreatitis
Ulcerative colitis

ASJC Scopus subject areas

Physiology
Gastroenterology

Access to Document

10.1007/s10620-021-06899-2

Cite this

@article{46079f5604e54f33a416ea6e711e3a18,

title = "Pancreatic Disorders in Patients with Inflammatory Bowel Disease",

abstract = "Inflammatory bowel disease (IBD) can involve multiple organ systems, and pancreatic manifestations of IBD are not uncommon. The incidence of several pancreatic diseases is more frequent in patients with Crohn{\textquoteright}s disease and ulcerative colitis than in the general population. Pancreatic manifestations in IBD include a heterogeneous group of disorders and abnormalities ranging from mild, self-limited disorders to severe diseases. Asymptomatic elevation of amylase and/or lipase is common. The risk of acute pancreatitis in patients with IBD is increased due to the higher incidence of cholelithiasis and drug-induced pancreatitis in this population. Patients with IBD commonly have altered pancreatic histology and chronic pancreatic exocrine dysfunction. Diagnosing acute pancreatitis in patients with IBD is challenging. In this review, we discuss the manifestations and possible causes of pancreatic abnormalities in patients with IBD.",

keywords = "Crohn{\textquoteright}s disease, Extraintestinal manifestations, Inflammatory bowel disease, Pancreatitis, Ulcerative colitis",

author = "Montenegro, {Marilia L.} and Corral, {Juan E.} and Lukens, {Frank J.} and Baoan Ji and Kr{\"o}ner, {Paul T.} and Farraye, {Francis A.} and Yan Bi",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.",

year = "2022",

month = feb,

doi = "10.1007/s10620-021-06899-2",

language = "English (US)",

volume = "67",

pages = "423--436",

journal = "Digestive diseases and sciences",

issn = "0163-2116",

publisher = "Springer New York",

number = "2",

}

TY - JOUR

T1 - Pancreatic Disorders in Patients with Inflammatory Bowel Disease

AU - Montenegro, Marilia L.

AU - Corral, Juan E.

AU - Lukens, Frank J.

AU - Ji, Baoan

AU - Kröner, Paul T.

AU - Farraye, Francis A.

AU - Bi, Yan

PY - 2022/2

Y1 - 2022/2

N2 - Inflammatory bowel disease (IBD) can involve multiple organ systems, and pancreatic manifestations of IBD are not uncommon. The incidence of several pancreatic diseases is more frequent in patients with Crohn’s disease and ulcerative colitis than in the general population. Pancreatic manifestations in IBD include a heterogeneous group of disorders and abnormalities ranging from mild, self-limited disorders to severe diseases. Asymptomatic elevation of amylase and/or lipase is common. The risk of acute pancreatitis in patients with IBD is increased due to the higher incidence of cholelithiasis and drug-induced pancreatitis in this population. Patients with IBD commonly have altered pancreatic histology and chronic pancreatic exocrine dysfunction. Diagnosing acute pancreatitis in patients with IBD is challenging. In this review, we discuss the manifestations and possible causes of pancreatic abnormalities in patients with IBD.

AB - Inflammatory bowel disease (IBD) can involve multiple organ systems, and pancreatic manifestations of IBD are not uncommon. The incidence of several pancreatic diseases is more frequent in patients with Crohn’s disease and ulcerative colitis than in the general population. Pancreatic manifestations in IBD include a heterogeneous group of disorders and abnormalities ranging from mild, self-limited disorders to severe diseases. Asymptomatic elevation of amylase and/or lipase is common. The risk of acute pancreatitis in patients with IBD is increased due to the higher incidence of cholelithiasis and drug-induced pancreatitis in this population. Patients with IBD commonly have altered pancreatic histology and chronic pancreatic exocrine dysfunction. Diagnosing acute pancreatitis in patients with IBD is challenging. In this review, we discuss the manifestations and possible causes of pancreatic abnormalities in patients with IBD.

KW - Crohn’s disease

KW - Extraintestinal manifestations

KW - Inflammatory bowel disease

KW - Pancreatitis

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=85101559066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85101559066&partnerID=8YFLogxK

U2 - 10.1007/s10620-021-06899-2

DO - 10.1007/s10620-021-06899-2

M3 - Review article

C2 - 33625614

AN - SCOPUS:85101559066

SN - 0163-2116

VL - 67

SP - 423

EP - 436

JO - Digestive diseases and sciences

JF - Digestive diseases and sciences

IS - 2

ER -

Pancreatic Disorders in Patients with Inflammatory Bowel Disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this