Pancreatic cancer risk is modulated by inflammatory potential of diet and ABO genotype: A consortia-based evaluation and replication study

Samuel Antwi, William R. Bamlet, Katrina S. Pedersen, Kari G. Chaffee, Harvey A. Risch, Nitin Shivappa, Susan E. Steck, Kristin E. Anderson, Paige M. Bracci, Jerry Polesel, Diego Serraino, Carlo La Vecchia, Cristina Bosetti, Donghui Li, Ann L Oberg, Alan A. Arslan, Demetrius Albanes, Eric J. Duell, Inge Huybrechts, Laufey T. AmundadottirRobert Hoover, Satu Mannisto, Stephen J. Chanock, Wei Zheng, Xiao Ou Shu, Magdalena Stepien, Federico Canzian, Bas Bueno-De-Mesquita, José Ramon Quirós, Anne Zeleniuch-Jacquotte, Fiona Bruinsma, Roger L. Milne, Graham G. Giles, James R. Hébert, Rachael Z. Stolzenberg-Solomon, Gloria M Petersen

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Abstract

Diets with high inflammatory potential are suspected to increase risk for pancreatic cancer (PC). Using pooled analyses, we examined whether this association applies to populations from different geographic regions and population subgroups with varying risks for PC, including variation in ABO blood type. Data from six case-control studies (cases, n = 2414; controls, n = 4528) in the Pancreatic Cancer Case-Control Consortium (PanC4) were analyzed, followed by replication in five nested case-control studies (cases, n = 1268; controls, n = 4215) from the Pancreatic Cancer Cohort Consortium (PanScan). Two polymorphisms in the ABO locus (rs505922 and rs8176746) were used to infer participants' blood types. Dietary questionnaire-derived nutrient/food intake was used to compute energy-adjusted dietary inflammatory index (E-DII) scores to assess inflammatory potential of diet. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable-adjusted logistic regression. Higher E-DII scores, reflecting greater inflammatory potential of diet, were associated with increased PC risk in PanC4 [ORQ5 versus Q1=2.20, 95% confidence interval (CI) = 1.85-2.61, Ptrend < 0.0001; ORcontinuous = 1.20, 95% CI = 1.17-1.24], and PanScan (ORQ5 versus Q1 = 1.23, 95% CI = 0.92-1.66, Ptrend = 0.008; ORcontinuous = 1.09, 95% CI = 1.02-1.15). As expected, genotype-derived non-O blood type was associated with increased PC risk in both the PanC4 and PanScan studies. Stratified analyses of associations between E-DII quintiles and PC by genotype-derived ABO blood type did not show interaction by blood type (Pinteraction = 0.10 in PanC4 and Pinteraction=0.13 in PanScan). The results show that consuming a pro-inflammatory diet and carrying non-O blood type are each individually, but not interactively, associated with increased PC risk.

Original languageEnglish (US)
Pages (from-to)1056-1067
Number of pages12
JournalCarcinogenesis
Volume39
Issue number8
DOIs
StatePublished - Jul 30 2018

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Pancreatic Neoplasms
Genotype
Diet
Confidence Intervals
Case-Control Studies
Population
Eating
Logistic Models
Odds Ratio
Food

ASJC Scopus subject areas

  • Cancer Research

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Pancreatic cancer risk is modulated by inflammatory potential of diet and ABO genotype : A consortia-based evaluation and replication study. / Antwi, Samuel; Bamlet, William R.; Pedersen, Katrina S.; Chaffee, Kari G.; Risch, Harvey A.; Shivappa, Nitin; Steck, Susan E.; Anderson, Kristin E.; Bracci, Paige M.; Polesel, Jerry; Serraino, Diego; La Vecchia, Carlo; Bosetti, Cristina; Li, Donghui; Oberg, Ann L; Arslan, Alan A.; Albanes, Demetrius; Duell, Eric J.; Huybrechts, Inge; Amundadottir, Laufey T.; Hoover, Robert; Mannisto, Satu; Chanock, Stephen J.; Zheng, Wei; Shu, Xiao Ou; Stepien, Magdalena; Canzian, Federico; Bueno-De-Mesquita, Bas; Quirós, José Ramon; Zeleniuch-Jacquotte, Anne; Bruinsma, Fiona; Milne, Roger L.; Giles, Graham G.; Hébert, James R.; Stolzenberg-Solomon, Rachael Z.; Petersen, Gloria M.

In: Carcinogenesis, Vol. 39, No. 8, 30.07.2018, p. 1056-1067.

Research output: Contribution to journalArticle

Antwi, S, Bamlet, WR, Pedersen, KS, Chaffee, KG, Risch, HA, Shivappa, N, Steck, SE, Anderson, KE, Bracci, PM, Polesel, J, Serraino, D, La Vecchia, C, Bosetti, C, Li, D, Oberg, AL, Arslan, AA, Albanes, D, Duell, EJ, Huybrechts, I, Amundadottir, LT, Hoover, R, Mannisto, S, Chanock, SJ, Zheng, W, Shu, XO, Stepien, M, Canzian, F, Bueno-De-Mesquita, B, Quirós, JR, Zeleniuch-Jacquotte, A, Bruinsma, F, Milne, RL, Giles, GG, Hébert, JR, Stolzenberg-Solomon, RZ & Petersen, GM 2018, 'Pancreatic cancer risk is modulated by inflammatory potential of diet and ABO genotype: A consortia-based evaluation and replication study', Carcinogenesis, vol. 39, no. 8, pp. 1056-1067. https://doi.org/10.1093/carcin/bgy072
Antwi, Samuel ; Bamlet, William R. ; Pedersen, Katrina S. ; Chaffee, Kari G. ; Risch, Harvey A. ; Shivappa, Nitin ; Steck, Susan E. ; Anderson, Kristin E. ; Bracci, Paige M. ; Polesel, Jerry ; Serraino, Diego ; La Vecchia, Carlo ; Bosetti, Cristina ; Li, Donghui ; Oberg, Ann L ; Arslan, Alan A. ; Albanes, Demetrius ; Duell, Eric J. ; Huybrechts, Inge ; Amundadottir, Laufey T. ; Hoover, Robert ; Mannisto, Satu ; Chanock, Stephen J. ; Zheng, Wei ; Shu, Xiao Ou ; Stepien, Magdalena ; Canzian, Federico ; Bueno-De-Mesquita, Bas ; Quirós, José Ramon ; Zeleniuch-Jacquotte, Anne ; Bruinsma, Fiona ; Milne, Roger L. ; Giles, Graham G. ; Hébert, James R. ; Stolzenberg-Solomon, Rachael Z. ; Petersen, Gloria M. / Pancreatic cancer risk is modulated by inflammatory potential of diet and ABO genotype : A consortia-based evaluation and replication study. In: Carcinogenesis. 2018 ; Vol. 39, No. 8. pp. 1056-1067.
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abstract = "Diets with high inflammatory potential are suspected to increase risk for pancreatic cancer (PC). Using pooled analyses, we examined whether this association applies to populations from different geographic regions and population subgroups with varying risks for PC, including variation in ABO blood type. Data from six case-control studies (cases, n = 2414; controls, n = 4528) in the Pancreatic Cancer Case-Control Consortium (PanC4) were analyzed, followed by replication in five nested case-control studies (cases, n = 1268; controls, n = 4215) from the Pancreatic Cancer Cohort Consortium (PanScan). Two polymorphisms in the ABO locus (rs505922 and rs8176746) were used to infer participants' blood types. Dietary questionnaire-derived nutrient/food intake was used to compute energy-adjusted dietary inflammatory index (E-DII) scores to assess inflammatory potential of diet. Pooled odds ratios (ORs) and 95{\%} confidence intervals (CIs) were calculated using multivariable-adjusted logistic regression. Higher E-DII scores, reflecting greater inflammatory potential of diet, were associated with increased PC risk in PanC4 [ORQ5 versus Q1=2.20, 95{\%} confidence interval (CI) = 1.85-2.61, Ptrend < 0.0001; ORcontinuous = 1.20, 95{\%} CI = 1.17-1.24], and PanScan (ORQ5 versus Q1 = 1.23, 95{\%} CI = 0.92-1.66, Ptrend = 0.008; ORcontinuous = 1.09, 95{\%} CI = 1.02-1.15). As expected, genotype-derived non-O blood type was associated with increased PC risk in both the PanC4 and PanScan studies. Stratified analyses of associations between E-DII quintiles and PC by genotype-derived ABO blood type did not show interaction by blood type (Pinteraction = 0.10 in PanC4 and Pinteraction=0.13 in PanScan). The results show that consuming a pro-inflammatory diet and carrying non-O blood type are each individually, but not interactively, associated with increased PC risk.",
author = "Samuel Antwi and Bamlet, {William R.} and Pedersen, {Katrina S.} and Chaffee, {Kari G.} and Risch, {Harvey A.} and Nitin Shivappa and Steck, {Susan E.} and Anderson, {Kristin E.} and Bracci, {Paige M.} and Jerry Polesel and Diego Serraino and {La Vecchia}, Carlo and Cristina Bosetti and Donghui Li and Oberg, {Ann L} and Arslan, {Alan A.} and Demetrius Albanes and Duell, {Eric J.} and Inge Huybrechts and Amundadottir, {Laufey T.} and Robert Hoover and Satu Mannisto and Chanock, {Stephen J.} and Wei Zheng and Shu, {Xiao Ou} and Magdalena Stepien and Federico Canzian and Bas Bueno-De-Mesquita and Quir{\'o}s, {Jos{\'e} Ramon} and Anne Zeleniuch-Jacquotte and Fiona Bruinsma and Milne, {Roger L.} and Giles, {Graham G.} and H{\'e}bert, {James R.} and Stolzenberg-Solomon, {Rachael Z.} and Petersen, {Gloria M}",
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T1 - Pancreatic cancer risk is modulated by inflammatory potential of diet and ABO genotype

T2 - A consortia-based evaluation and replication study

AU - Antwi, Samuel

AU - Bamlet, William R.

AU - Pedersen, Katrina S.

AU - Chaffee, Kari G.

AU - Risch, Harvey A.

AU - Shivappa, Nitin

AU - Steck, Susan E.

AU - Anderson, Kristin E.

AU - Bracci, Paige M.

AU - Polesel, Jerry

AU - Serraino, Diego

AU - La Vecchia, Carlo

AU - Bosetti, Cristina

AU - Li, Donghui

AU - Oberg, Ann L

AU - Arslan, Alan A.

AU - Albanes, Demetrius

AU - Duell, Eric J.

AU - Huybrechts, Inge

AU - Amundadottir, Laufey T.

AU - Hoover, Robert

AU - Mannisto, Satu

AU - Chanock, Stephen J.

AU - Zheng, Wei

AU - Shu, Xiao Ou

AU - Stepien, Magdalena

AU - Canzian, Federico

AU - Bueno-De-Mesquita, Bas

AU - Quirós, José Ramon

AU - Zeleniuch-Jacquotte, Anne

AU - Bruinsma, Fiona

AU - Milne, Roger L.

AU - Giles, Graham G.

AU - Hébert, James R.

AU - Stolzenberg-Solomon, Rachael Z.

AU - Petersen, Gloria M

PY - 2018/7/30

Y1 - 2018/7/30

N2 - Diets with high inflammatory potential are suspected to increase risk for pancreatic cancer (PC). Using pooled analyses, we examined whether this association applies to populations from different geographic regions and population subgroups with varying risks for PC, including variation in ABO blood type. Data from six case-control studies (cases, n = 2414; controls, n = 4528) in the Pancreatic Cancer Case-Control Consortium (PanC4) were analyzed, followed by replication in five nested case-control studies (cases, n = 1268; controls, n = 4215) from the Pancreatic Cancer Cohort Consortium (PanScan). Two polymorphisms in the ABO locus (rs505922 and rs8176746) were used to infer participants' blood types. Dietary questionnaire-derived nutrient/food intake was used to compute energy-adjusted dietary inflammatory index (E-DII) scores to assess inflammatory potential of diet. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable-adjusted logistic regression. Higher E-DII scores, reflecting greater inflammatory potential of diet, were associated with increased PC risk in PanC4 [ORQ5 versus Q1=2.20, 95% confidence interval (CI) = 1.85-2.61, Ptrend < 0.0001; ORcontinuous = 1.20, 95% CI = 1.17-1.24], and PanScan (ORQ5 versus Q1 = 1.23, 95% CI = 0.92-1.66, Ptrend = 0.008; ORcontinuous = 1.09, 95% CI = 1.02-1.15). As expected, genotype-derived non-O blood type was associated with increased PC risk in both the PanC4 and PanScan studies. Stratified analyses of associations between E-DII quintiles and PC by genotype-derived ABO blood type did not show interaction by blood type (Pinteraction = 0.10 in PanC4 and Pinteraction=0.13 in PanScan). The results show that consuming a pro-inflammatory diet and carrying non-O blood type are each individually, but not interactively, associated with increased PC risk.

AB - Diets with high inflammatory potential are suspected to increase risk for pancreatic cancer (PC). Using pooled analyses, we examined whether this association applies to populations from different geographic regions and population subgroups with varying risks for PC, including variation in ABO blood type. Data from six case-control studies (cases, n = 2414; controls, n = 4528) in the Pancreatic Cancer Case-Control Consortium (PanC4) were analyzed, followed by replication in five nested case-control studies (cases, n = 1268; controls, n = 4215) from the Pancreatic Cancer Cohort Consortium (PanScan). Two polymorphisms in the ABO locus (rs505922 and rs8176746) were used to infer participants' blood types. Dietary questionnaire-derived nutrient/food intake was used to compute energy-adjusted dietary inflammatory index (E-DII) scores to assess inflammatory potential of diet. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable-adjusted logistic regression. Higher E-DII scores, reflecting greater inflammatory potential of diet, were associated with increased PC risk in PanC4 [ORQ5 versus Q1=2.20, 95% confidence interval (CI) = 1.85-2.61, Ptrend < 0.0001; ORcontinuous = 1.20, 95% CI = 1.17-1.24], and PanScan (ORQ5 versus Q1 = 1.23, 95% CI = 0.92-1.66, Ptrend = 0.008; ORcontinuous = 1.09, 95% CI = 1.02-1.15). As expected, genotype-derived non-O blood type was associated with increased PC risk in both the PanC4 and PanScan studies. Stratified analyses of associations between E-DII quintiles and PC by genotype-derived ABO blood type did not show interaction by blood type (Pinteraction = 0.10 in PanC4 and Pinteraction=0.13 in PanScan). The results show that consuming a pro-inflammatory diet and carrying non-O blood type are each individually, but not interactively, associated with increased PC risk.

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