Oxidative stress biomarkers in endometrial secretions: A comparison between successful and unsuccessful in vitro fertilization cycles

Mohammad Ehsan Rahiminejad, Amirhossein Moaddab, Maziar Ganji, Nika Eskandari, Mayel Yepez, Soghra Rabiee, Meredith Wise, Rodrigo Ruano, Akram Ranjbar

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A potential role of oxidative stress has been implicated in the outcome of various steps of assisted reproductive technology (ART). In a prospective cohort study, a total of 100 patients undergoing IVF/ICSI procedure due to male factor infertility were recruited based on the inclusion criteria. In all patients, 1-2 ml of endometrial secretions was aspirated prior to embryo transfer. The oxidative stress markers in endometrial secretions, including superoxide dismutase (SOD), catalase (CAT) activities, lipid peroxidation (LPO), total thiol groups (TTG), and total antioxidant power (TAP) were investigated and compared among study groups including term pregnancy, failed IVF cycle, and miscarriage. P < 0.05 was considered statistically different. Of the 100 patients, 28 cases (28%) resulted in ongoing pregnancy (biochemical pregnancy followed by clinical pregnancy), 11 cases (11%) resulted in miscarriage, and 61 cases (61%), resulted in failed IVF cycle. SOD, LPO, CAT, and TAP levels in the endometrial secretions of the three groups were statistically different (P-value <0.01, <0.001, <0.001, and <0.001, respectively). TTG levels in endometrial secretion of three groups were not statistically different (P-value = 0.837). Our results indicated that higher levels of antioxidants such as SOD, CAT, or TAP, and lower levels of oxidative stress markers such as LPO in the endometrial secretions were associated with successful IVF outcome.

Original languageEnglish (US)
Pages (from-to)70-75
Number of pages6
JournalJournal of Reproductive Immunology
Volume116
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Fingerprint

Fertilization in Vitro
Oxidative Stress
Antioxidants
Biomarkers
Catalase
Lipid Peroxidation
Superoxide Dismutase
Pregnancy
Spontaneous Abortion
Sulfhydryl Compounds
Assisted Reproductive Techniques
Intracytoplasmic Sperm Injections
Embryo Transfer
Male Infertility
Cohort Studies
Prospective Studies

Keywords

  • Implantation
  • In vitro fertilization
  • Outcome
  • Oxidative stress
  • Pregnancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Oxidative stress biomarkers in endometrial secretions : A comparison between successful and unsuccessful in vitro fertilization cycles. / Rahiminejad, Mohammad Ehsan; Moaddab, Amirhossein; Ganji, Maziar; Eskandari, Nika; Yepez, Mayel; Rabiee, Soghra; Wise, Meredith; Ruano, Rodrigo; Ranjbar, Akram.

In: Journal of Reproductive Immunology, Vol. 116, 01.08.2016, p. 70-75.

Research output: Contribution to journalArticle

Rahiminejad, Mohammad Ehsan ; Moaddab, Amirhossein ; Ganji, Maziar ; Eskandari, Nika ; Yepez, Mayel ; Rabiee, Soghra ; Wise, Meredith ; Ruano, Rodrigo ; Ranjbar, Akram. / Oxidative stress biomarkers in endometrial secretions : A comparison between successful and unsuccessful in vitro fertilization cycles. In: Journal of Reproductive Immunology. 2016 ; Vol. 116. pp. 70-75.
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