Overwork effect on partially denervated rat soleus muscle

Carolyn L. Kinney, M. M. Jaweed, G. J. Herbison, J. F. Ditunno

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The purpose of this study was to assess the effect of overwork induced by synergistic tenotomy on the muscle weight (MW) and isometric tetanic tension (P0) of the partially denervated rat soleus muscle. Forty-nine young adult male Sprague-Dawley rats were divided into six groups (n = 5 to 9): normal control (N), normal synergistically tenotomized (N-ST), L4 denervated control (L4), L4 denervated synergistically tenotomized (L4-ST), L5 denervated control (L5), and L5 denervated synergistically tenotomized (L5-ST). Bilateral L4 or L5 root transections produced partial denervation. To yield soleus muscle overwork the gastrocnemius and plantaris muscles were bilaterally tenotomized in all ST groups at the time of denervation. The soleus MW and P0 were examined seven days following denervation and tenotomy. Compared to their respective controls, there was increased MW in the N-ST (43.5%, p<0.01) and the L4-ST (38.6% p<0.01) groups. The L5-ST group showed no significant change in MW compared to the L5 group. Tetanic tension was increased only in the N-ST group. The L4-ST and L5-ST groups did not show any change in P0 compared to their respective controls. Despite marked denervation, the L5 group did not show any atrophy as compared to the N group, suggesting passive stretch of the denervated muscle fibers, hypertrophy of the innervated muscle fibers and peripheral sprouting prevented the loss of MW due to denervation. Overwork in this markedly denervated group could not produce any increase in the MW or P0. It is suggested that peripheral sprouting and stretch-induced overwork of muscle fibers may be responsible for sparing of muscle atrophy and P0.

Original languageEnglish (US)
Pages (from-to)286-289
Number of pages4
JournalArchives of Physical Medicine and Rehabilitation
Volume67
Issue number5
StatePublished - 1986
Externally publishedYes

Fingerprint

Skeletal Muscle
Denervation
Muscles
Weights and Measures
Tenotomy
Muscular Atrophy
Hypertrophy
Atrophy
Sprague Dawley Rats
Weight Loss
Young Adult

Keywords

  • Exertion
  • Muscle contraction
  • Muscle denervation
  • Muscular atrophy

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Kinney, C. L., Jaweed, M. M., Herbison, G. J., & Ditunno, J. F. (1986). Overwork effect on partially denervated rat soleus muscle. Archives of Physical Medicine and Rehabilitation, 67(5), 286-289.

Overwork effect on partially denervated rat soleus muscle. / Kinney, Carolyn L.; Jaweed, M. M.; Herbison, G. J.; Ditunno, J. F.

In: Archives of Physical Medicine and Rehabilitation, Vol. 67, No. 5, 1986, p. 286-289.

Research output: Contribution to journalArticle

Kinney, CL, Jaweed, MM, Herbison, GJ & Ditunno, JF 1986, 'Overwork effect on partially denervated rat soleus muscle', Archives of Physical Medicine and Rehabilitation, vol. 67, no. 5, pp. 286-289.
Kinney CL, Jaweed MM, Herbison GJ, Ditunno JF. Overwork effect on partially denervated rat soleus muscle. Archives of Physical Medicine and Rehabilitation. 1986;67(5):286-289.
Kinney, Carolyn L. ; Jaweed, M. M. ; Herbison, G. J. ; Ditunno, J. F. / Overwork effect on partially denervated rat soleus muscle. In: Archives of Physical Medicine and Rehabilitation. 1986 ; Vol. 67, No. 5. pp. 286-289.
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AB - The purpose of this study was to assess the effect of overwork induced by synergistic tenotomy on the muscle weight (MW) and isometric tetanic tension (P0) of the partially denervated rat soleus muscle. Forty-nine young adult male Sprague-Dawley rats were divided into six groups (n = 5 to 9): normal control (N), normal synergistically tenotomized (N-ST), L4 denervated control (L4), L4 denervated synergistically tenotomized (L4-ST), L5 denervated control (L5), and L5 denervated synergistically tenotomized (L5-ST). Bilateral L4 or L5 root transections produced partial denervation. To yield soleus muscle overwork the gastrocnemius and plantaris muscles were bilaterally tenotomized in all ST groups at the time of denervation. The soleus MW and P0 were examined seven days following denervation and tenotomy. Compared to their respective controls, there was increased MW in the N-ST (43.5%, p<0.01) and the L4-ST (38.6% p<0.01) groups. The L5-ST group showed no significant change in MW compared to the L5 group. Tetanic tension was increased only in the N-ST group. The L4-ST and L5-ST groups did not show any change in P0 compared to their respective controls. Despite marked denervation, the L5 group did not show any atrophy as compared to the N group, suggesting passive stretch of the denervated muscle fibers, hypertrophy of the innervated muscle fibers and peripheral sprouting prevented the loss of MW due to denervation. Overwork in this markedly denervated group could not produce any increase in the MW or P0. It is suggested that peripheral sprouting and stretch-induced overwork of muscle fibers may be responsible for sparing of muscle atrophy and P0.

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