Overview of dementia lacking distinctive histology

Pathological designation of a progressive dementia

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The group of progressive dementing illnesses that lack distinctive histologic features includes at least four variants: a cortical type, a thalamostriate type, a motor neuronopathy type and a leukogliotic type. While the clinical presentation of some cases is that of anterograde amnesia, progressive aphasia and dysexecutive syndrome are the most common initial symptom complexes. A large number of reported cases are familial, although no abnormal gene has been identified. Pathologically, these illnesses are defined by cortical, hippocampal, striatal, medial thalamic, nigral and motor nuclei cell dropout and astrogliosis. In some cases, white matter gliosis is striking. Identification of specific histological or molecular markers of at least some of these conditions will greatly advance our understanding of these specific conditions as well as dementing illnesses in general.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalDementia
Volume4
Issue number3-4
StatePublished - 1993
Externally publishedYes

Fingerprint

Anterograde Amnesia
Corpus Striatum
Gliosis
Aphasia
Substantia Nigra
Cell Nucleus
Dementia
Histology
Genes
White Matter

Keywords

  • Dementia
  • Frontal lobes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Neuropsychology and Physiological Psychology

Cite this

Overview of dementia lacking distinctive histology : Pathological designation of a progressive dementia. / Knopman, David S.

In: Dementia, Vol. 4, No. 3-4, 1993, p. 132-136.

Research output: Contribution to journalArticle

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