Outcomes of Pituitary Radiation for Cushing's Disease

Natasha Ironside; Ching Jen Chen; Cheng Chia Lee; Daniel M. Trifiletti; Mary Lee Vance; Jason P. Sheehan

doi:10.1016/j.ecl.2018.01.002

Outcomes of Pituitary Radiation for Cushing's Disease

Natasha Ironside, Ching Jen Chen, Cheng Chia Lee, Daniel M. Trifiletti, Mary Lee Vance, Jason P. Sheehan

Radiation Oncology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

6 Scopus citations

Abstract

Achievement of biochemical remission with preservation of normal pituitary function is the goal of treatment for Cushing's disease. For patients with persistent or recurrent Cushing's disease after transsphenoidal resection, radiation therapy may be a safe and effective treatment. Stereotactic radiosurgery is favored over conventional fractionated external beam radiation. Hormonal recurrence rates range from 0% to 36% at 8 years after treatment. Tumor control rates are high. New pituitary hormone deficiency is the most common adverse effect after stereotactic radiosurgery and external beam radiation. The effects of radiation planning optimization and use of adjuvant medication on endocrine remission rates warrant investigation.

Original language	English (US)
Title of host publication	Endocrinology and Metabolism Clinics of North America
Editors	Adriana G. Ioachimescu
Publisher	W.B. Saunders
Pages	349-365
Number of pages	17
Volume	47
Edition	2
ISBN (Print)	9780323612937
DOIs	https://doi.org/10.1016/j.ecl.2018.01.002
State	Published - Jun 2018

Keywords

Cushing's disease
Endocrine
Radiation therapy
Remission
Stereotactic radiosurgery

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.ecl.2018.01.002

Cite this

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abstract = "Achievement of biochemical remission with preservation of normal pituitary function is the goal of treatment for Cushing's disease. For patients with persistent or recurrent Cushing's disease after transsphenoidal resection, radiation therapy may be a safe and effective treatment. Stereotactic radiosurgery is favored over conventional fractionated external beam radiation. Hormonal recurrence rates range from 0% to 36% at 8 years after treatment. Tumor control rates are high. New pituitary hormone deficiency is the most common adverse effect after stereotactic radiosurgery and external beam radiation. The effects of radiation planning optimization and use of adjuvant medication on endocrine remission rates warrant investigation.",

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AU - Vance, Mary Lee

AU - Sheehan, Jason P.

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Outcomes of Pituitary Radiation for Cushing's Disease

Abstract

Keywords

ASJC Scopus subject areas

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