Outcomes of Colorectal Cancer Arising in Solid Organ Transplant Recipients

Amit Merchea, Zaid M. Abdelsattar, Timucin Taner, Patrick G. Dean, Dorin T. Colibaseanu, David Larson, Eric Dozois

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Introduction: The incidence of colorectal cancer posttransplantation is unclear. Limited reports exist and have conflicting conclusions. We aimed to review the clinical features and oncologic outcomes of colorectal cancer in transplant recipients at our institution. Methods: A retrospective review of all patients diagnosed with colorectal cancer after solid organ transplantation between 2000 and 2011 was conducted. Clinical features and outcomes were reviewed. Results: Twenty of 3,946 patients were identified. The most common single organ transplanted was the kidney (n = 8). Six patients had multiorgan transplantation. Median age of diagnosis of cancer was 64.3 years, and median time from transplant to diagnosis of cancer was 8.7 years. Ten patients were symptomatic at presentation. Cancer was identified on routine colonoscopy in seven patients. Tumors were most commonly found in the right colon (n = 14, 70 %). Six patients had stage IV disease at presentation. Short-term morbidity was identified in 11 patients. Postoperative mortality occurred in one patient. Median follow-up was 2.47 years. Overall survival at 5 years was 69 %, and disease-free survival was 68 %. Distant recurrence was seen in 3 (15 %) patients. Conclusion: Colorectal cancer in these patients is rare, and surgery can be done safely. Vigilant screening must be maintained in this patient population.

Original languageEnglish (US)
Pages (from-to)599-604
Number of pages6
JournalJournal of Gastrointestinal Surgery
Volume18
Issue number3
DOIs
StatePublished - Mar 2014

Fingerprint

Colorectal Neoplasms
Transplants
Neoplasms
Transplant Recipients
Organ Transplantation
Colonoscopy
Disease-Free Survival
Colon
Transplantation
Morbidity
Kidney
Recurrence
Survival
Mortality
Incidence

Keywords

  • Colorectal cancer
  • Screening
  • Transplant
  • Transplantation

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Outcomes of Colorectal Cancer Arising in Solid Organ Transplant Recipients. / Merchea, Amit; Abdelsattar, Zaid M.; Taner, Timucin; Dean, Patrick G.; Colibaseanu, Dorin T.; Larson, David; Dozois, Eric.

In: Journal of Gastrointestinal Surgery, Vol. 18, No. 3, 03.2014, p. 599-604.

Research output: Contribution to journalArticle

Merchea, Amit ; Abdelsattar, Zaid M. ; Taner, Timucin ; Dean, Patrick G. ; Colibaseanu, Dorin T. ; Larson, David ; Dozois, Eric. / Outcomes of Colorectal Cancer Arising in Solid Organ Transplant Recipients. In: Journal of Gastrointestinal Surgery. 2014 ; Vol. 18, No. 3. pp. 599-604.
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abstract = "Introduction: The incidence of colorectal cancer posttransplantation is unclear. Limited reports exist and have conflicting conclusions. We aimed to review the clinical features and oncologic outcomes of colorectal cancer in transplant recipients at our institution. Methods: A retrospective review of all patients diagnosed with colorectal cancer after solid organ transplantation between 2000 and 2011 was conducted. Clinical features and outcomes were reviewed. Results: Twenty of 3,946 patients were identified. The most common single organ transplanted was the kidney (n = 8). Six patients had multiorgan transplantation. Median age of diagnosis of cancer was 64.3 years, and median time from transplant to diagnosis of cancer was 8.7 years. Ten patients were symptomatic at presentation. Cancer was identified on routine colonoscopy in seven patients. Tumors were most commonly found in the right colon (n = 14, 70 {\%}). Six patients had stage IV disease at presentation. Short-term morbidity was identified in 11 patients. Postoperative mortality occurred in one patient. Median follow-up was 2.47 years. Overall survival at 5 years was 69 {\%}, and disease-free survival was 68 {\%}. Distant recurrence was seen in 3 (15 {\%}) patients. Conclusion: Colorectal cancer in these patients is rare, and surgery can be done safely. Vigilant screening must be maintained in this patient population.",
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