Outcomes of Adolescent-Onset Postural Orthostatic Tachycardia Syndrome

Roma Bhatia, Sarah J. Kizilbash, Shelley P. Ahrens, Jill M. Killian, Stephanie A. Kimmes, Erin E. Knoebel, Prasuna Muppa, Amy L. Weaver, Philip R. Fischer

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20 Scopus citations


Objectives: To determine the clinical course of adolescent-onset postural orthostatic tachycardia syndrome (POTS) and to assess health-related quality of life, 2-10 years after diagnosis. Study design: Pediatric patients, 13-18 years of age, diagnosed with POTS at Mayo Clinic, Rochester, from 2003 to 2010 were mailed a questionnaire if they were at least 18 years of age at the time of the mailing. The primary outcome measures were norm-based, age- and sex-adjusted, 36-Item Short Form Health Survey physical composite score and mental composite score. Results: The survey was mailed to 502 patients with a response rate of 34% (n = 172). The mean duration from diagnosis to survey completion was 5.4 (SD, 1.9) years; the mean age of the respondents at the time of the survey was 21.8 (2.2) years. The responders were predominantly females (84% vs 68% of nonresponders; P <.001). Only 33 (19%) respondents reported complete resolution of symptoms, and an additional 51% reported persistent but improved symptoms, and 28 (16%) had only intermittent symptoms. The majority (71%) consider their health at least "good." The mean physical composite score was significantly lower than the population norm (mean [SD], 36.6 [15.8] vs 50; P <.001), however, the corresponding mean mental composite score was normal (50.1 [11.2]). Conclusions: Overall, 86% of adolescents with POTS report resolved, improved, or just intermittent symptoms, when assessed via questionnaire at an average of 5 years after initial treatment. Patients with persistent symptoms have more physical than mental health concerns.

Original languageEnglish (US)
JournalJournal of Pediatrics
StateAccepted/In press - Sep 21 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Bhatia, R., Kizilbash, S. J., Ahrens, S. P., Killian, J. M., Kimmes, S. A., Knoebel, E. E., Muppa, P., Weaver, A. L., & Fischer, P. R. (Accepted/In press). Outcomes of Adolescent-Onset Postural Orthostatic Tachycardia Syndrome. Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2016.02.035