Outcomes after whole-brain radiotherapy for brain metastases with 5×4 gy: Importance of overall treatment time

Dirk Rades, Theo Veninga, Stefan Janssen, Steven E. Schild

Research output: Contribution to journalArticle

Abstract

Background/Aim: To investigate the impact of overall treatment time (OTT) of whole-brain radiotherapy (WBRT) with 5×4 Gy on outcomes. Patients and Methods: Forty-four patients for whom WBRT was started on a Monday (OTT=5 days) were compared to 136 patients, for whom WBRT was started on another weekday (OTT=7 days; weekend break) regarding intracerebral control and survival. Seven other factors were also analyzed. Results: Intracerebral control at 6 and 12 months was 64% and 36% after OTT of 5 days vs. 57% and 38% after OTT of 7 days (p=0.68). On multivariate analysis, intracerebral control was positively associated with a better Eastern Cooperative Oncology Group performance score (ECOG-PS) (p<0.001). Survival at 6 and 12 months was 36% and 16% after OTT of 5 days vs. 35% and 19% after OTT of 7 days (p=0.81). On multivariate analysis, survival was positively associated with better ECOG-PS (p<0.001) and absence of extracerebral lesions (p=0.004). Conclusion: Prolongation of OTT to 7 days had no impact on outcomes after WBRT with 5×4 Gy.

Original languageEnglish (US)
Pages (from-to)4941-4945
Number of pages5
JournalAnticancer Research
Volume36
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Radiotherapy
Neoplasm Metastasis
Brain
Therapeutics
Survival
Multivariate Analysis

Keywords

  • Brain metastases
  • Intracerebral control
  • Overall treatment time
  • Survival
  • Whole-brain radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Outcomes after whole-brain radiotherapy for brain metastases with 5×4 gy : Importance of overall treatment time. / Rades, Dirk; Veninga, Theo; Janssen, Stefan; Schild, Steven E.

In: Anticancer Research, Vol. 36, No. 9, 01.09.2016, p. 4941-4945.

Research output: Contribution to journalArticle

Rades, Dirk ; Veninga, Theo ; Janssen, Stefan ; Schild, Steven E. / Outcomes after whole-brain radiotherapy for brain metastases with 5×4 gy : Importance of overall treatment time. In: Anticancer Research. 2016 ; Vol. 36, No. 9. pp. 4941-4945.
@article{7cc63e62df8145bfa99c3e7b1bc0ad1c,
title = "Outcomes after whole-brain radiotherapy for brain metastases with 5×4 gy: Importance of overall treatment time",
abstract = "Background/Aim: To investigate the impact of overall treatment time (OTT) of whole-brain radiotherapy (WBRT) with 5×4 Gy on outcomes. Patients and Methods: Forty-four patients for whom WBRT was started on a Monday (OTT=5 days) were compared to 136 patients, for whom WBRT was started on another weekday (OTT=7 days; weekend break) regarding intracerebral control and survival. Seven other factors were also analyzed. Results: Intracerebral control at 6 and 12 months was 64{\%} and 36{\%} after OTT of 5 days vs. 57{\%} and 38{\%} after OTT of 7 days (p=0.68). On multivariate analysis, intracerebral control was positively associated with a better Eastern Cooperative Oncology Group performance score (ECOG-PS) (p<0.001). Survival at 6 and 12 months was 36{\%} and 16{\%} after OTT of 5 days vs. 35{\%} and 19{\%} after OTT of 7 days (p=0.81). On multivariate analysis, survival was positively associated with better ECOG-PS (p<0.001) and absence of extracerebral lesions (p=0.004). Conclusion: Prolongation of OTT to 7 days had no impact on outcomes after WBRT with 5×4 Gy.",
keywords = "Brain metastases, Intracerebral control, Overall treatment time, Survival, Whole-brain radiotherapy",
author = "Dirk Rades and Theo Veninga and Stefan Janssen and Schild, {Steven E.}",
year = "2016",
month = "9",
day = "1",
doi = "10.21873/anticanres.11060",
language = "English (US)",
volume = "36",
pages = "4941--4945",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "9",

}

TY - JOUR

T1 - Outcomes after whole-brain radiotherapy for brain metastases with 5×4 gy

T2 - Importance of overall treatment time

AU - Rades, Dirk

AU - Veninga, Theo

AU - Janssen, Stefan

AU - Schild, Steven E.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background/Aim: To investigate the impact of overall treatment time (OTT) of whole-brain radiotherapy (WBRT) with 5×4 Gy on outcomes. Patients and Methods: Forty-four patients for whom WBRT was started on a Monday (OTT=5 days) were compared to 136 patients, for whom WBRT was started on another weekday (OTT=7 days; weekend break) regarding intracerebral control and survival. Seven other factors were also analyzed. Results: Intracerebral control at 6 and 12 months was 64% and 36% after OTT of 5 days vs. 57% and 38% after OTT of 7 days (p=0.68). On multivariate analysis, intracerebral control was positively associated with a better Eastern Cooperative Oncology Group performance score (ECOG-PS) (p<0.001). Survival at 6 and 12 months was 36% and 16% after OTT of 5 days vs. 35% and 19% after OTT of 7 days (p=0.81). On multivariate analysis, survival was positively associated with better ECOG-PS (p<0.001) and absence of extracerebral lesions (p=0.004). Conclusion: Prolongation of OTT to 7 days had no impact on outcomes after WBRT with 5×4 Gy.

AB - Background/Aim: To investigate the impact of overall treatment time (OTT) of whole-brain radiotherapy (WBRT) with 5×4 Gy on outcomes. Patients and Methods: Forty-four patients for whom WBRT was started on a Monday (OTT=5 days) were compared to 136 patients, for whom WBRT was started on another weekday (OTT=7 days; weekend break) regarding intracerebral control and survival. Seven other factors were also analyzed. Results: Intracerebral control at 6 and 12 months was 64% and 36% after OTT of 5 days vs. 57% and 38% after OTT of 7 days (p=0.68). On multivariate analysis, intracerebral control was positively associated with a better Eastern Cooperative Oncology Group performance score (ECOG-PS) (p<0.001). Survival at 6 and 12 months was 36% and 16% after OTT of 5 days vs. 35% and 19% after OTT of 7 days (p=0.81). On multivariate analysis, survival was positively associated with better ECOG-PS (p<0.001) and absence of extracerebral lesions (p=0.004). Conclusion: Prolongation of OTT to 7 days had no impact on outcomes after WBRT with 5×4 Gy.

KW - Brain metastases

KW - Intracerebral control

KW - Overall treatment time

KW - Survival

KW - Whole-brain radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=84991648504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991648504&partnerID=8YFLogxK

U2 - 10.21873/anticanres.11060

DO - 10.21873/anticanres.11060

M3 - Article

C2 - 27630352

AN - SCOPUS:84991648504

VL - 36

SP - 4941

EP - 4945

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 9

ER -