Outcome following decompressive craniectomy for malignant middle cerebral artery infarction in children

Sabrina E. Smith, Fenella J. Kirkham, Gabrielle Deveber, Guy Millman, Peter B. Dirks, Elaine C Wirrell, Albert E. Telfeian, Kim Sykes, Karen Barlow, Rebecca Ichord

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Aim: Mortality from malignant middle cerebral artery infarction (MMCAI) approaches 80% in adult series. Although decompressive craniectomy decreases mortality and leads to an acceptable outcome in selected adult patients, there are few data on MMCAI in children with stroke. This study evaluated the frequency of MMCAI and the use of decompressive craniectomy in children. Method: We retrospectively reviewed cases of MMCAI from five pediatric tertiary care centers. Results: Ten children (two females, eight males; median age 9y 10mo, range 22mo-14y) had MMCAI, with a median Glasgow Coma Scale score of 6 (range 3-9). MMCAI represented fewer than 2% of cases of pediatric arterial ischemic stroke. Three patients who did not undergo decompression, all of whom had monitoring of intracranial pressure, developed intractable intracranial hypertension, and fulfilled criteria for brain death. In contrast, seven patients underwent decompressive craniectomy and survived, with rapid improvement in their level of consciousness postoperatively. All seven survivors now walk independently with mild to moderate residual hemiparesis and speak fluently, even though four had left-sided infarcts. Interpretation: Decompressive craniectomy can lead to a moderately good outcome for children with MMCAI and should be considered, even with symptomatic stroke and deep coma. Monitoring of intracranial pressure may delay life-saving treatment.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalDevelopmental Medicine and Child Neurology
Volume53
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

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Decompressive Craniectomy
Middle Cerebral Artery Infarction
Stroke
Intracranial Pressure
Pediatrics
Glasgow Coma Scale
Brain Death
Intracranial Hypertension
Mortality
Paresis
Coma
Decompression
Consciousness
Tertiary Care Centers
Survivors

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience

Cite this

Outcome following decompressive craniectomy for malignant middle cerebral artery infarction in children. / Smith, Sabrina E.; Kirkham, Fenella J.; Deveber, Gabrielle; Millman, Guy; Dirks, Peter B.; Wirrell, Elaine C; Telfeian, Albert E.; Sykes, Kim; Barlow, Karen; Ichord, Rebecca.

In: Developmental Medicine and Child Neurology, Vol. 53, No. 1, 01.2011, p. 29-33.

Research output: Contribution to journalArticle

Smith, SE, Kirkham, FJ, Deveber, G, Millman, G, Dirks, PB, Wirrell, EC, Telfeian, AE, Sykes, K, Barlow, K & Ichord, R 2011, 'Outcome following decompressive craniectomy for malignant middle cerebral artery infarction in children', Developmental Medicine and Child Neurology, vol. 53, no. 1, pp. 29-33. https://doi.org/10.1111/j.1469-8749.2010.03775.x
Smith, Sabrina E. ; Kirkham, Fenella J. ; Deveber, Gabrielle ; Millman, Guy ; Dirks, Peter B. ; Wirrell, Elaine C ; Telfeian, Albert E. ; Sykes, Kim ; Barlow, Karen ; Ichord, Rebecca. / Outcome following decompressive craniectomy for malignant middle cerebral artery infarction in children. In: Developmental Medicine and Child Neurology. 2011 ; Vol. 53, No. 1. pp. 29-33.
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