Our Evolving Understanding of Migraine with Aura

Justin M. DeLange; F. Michael Cutrer

doi:10.1007/s11916-014-0453-0

Our Evolving Understanding of Migraine with Aura

Justin M. DeLange, F. Michael Cutrer

Neurology

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Migraine aura consists of fully reversible focal neurologic symptoms that may precede or coexist with headache in a significant minority of migraine patients. Typical aura symptoms include visual, sensory, and language disturbances. The most recent International Classification of Headache Disorders, 3rd edition (beta version) has added other aura types such as brainstem localizing symptoms, lateralizing weakness, and monocular visual loss. Currently available data from animal models and functional neuroimaging in humans implicate cortical spreading depression (CSD) as the phenomenon underlying migraine aura. Ongoing study suggests that susceptibility to migraine aura and CSD may be genetically mediated. CSD appears to be a potential target for future development of migraine-specific preventive therapies.

Original language	English (US)
Article number	453
Journal	Current pain and headache reports
Volume	18
Issue number	10
DOIs	https://doi.org/10.1007/s11916-014-0453-0
State	Published - Oct 2014

Keywords

Aura
Cortical spreading depression
Focal neurologic symptoms
Migraine

ASJC Scopus subject areas

Clinical Neurology
Anesthesiology and Pain Medicine

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10.1007/s11916-014-0453-0

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title = "Our Evolving Understanding of Migraine with Aura",

abstract = "Migraine aura consists of fully reversible focal neurologic symptoms that may precede or coexist with headache in a significant minority of migraine patients. Typical aura symptoms include visual, sensory, and language disturbances. The most recent International Classification of Headache Disorders, 3rd edition (beta version) has added other aura types such as brainstem localizing symptoms, lateralizing weakness, and monocular visual loss. Currently available data from animal models and functional neuroimaging in humans implicate cortical spreading depression (CSD) as the phenomenon underlying migraine aura. Ongoing study suggests that susceptibility to migraine aura and CSD may be genetically mediated. CSD appears to be a potential target for future development of migraine-specific preventive therapies.",

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AB - Migraine aura consists of fully reversible focal neurologic symptoms that may precede or coexist with headache in a significant minority of migraine patients. Typical aura symptoms include visual, sensory, and language disturbances. The most recent International Classification of Headache Disorders, 3rd edition (beta version) has added other aura types such as brainstem localizing symptoms, lateralizing weakness, and monocular visual loss. Currently available data from animal models and functional neuroimaging in humans implicate cortical spreading depression (CSD) as the phenomenon underlying migraine aura. Ongoing study suggests that susceptibility to migraine aura and CSD may be genetically mediated. CSD appears to be a potential target for future development of migraine-specific preventive therapies.

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Our Evolving Understanding of Migraine with Aura

Abstract

Keywords

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