Orthostatic intolerance and motion sickness after parabolic flight

T. T. Schlegel, T. E. Brown, S. J. Wood, E. W. Benavides, R. L. Bondar, F. Stein, P. Moradshahi, D. L. Harm, J. M. Fritsch-Yelle, P. A. Low

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Because it is not clear that the induction of orthostatic intolerance in returning astronauts always requires prolonged exposure to microgravity, we investigated orthostatic tolerance and autonomic cardiovascular function in 16 healthy subjects before and after the brief micro- and hypergravity of parabolic flight. Concomitantly, we investigated the effect of parabolic flight-induced vomiting on orthostatic tolerance, R-wave-R-wave interval and arterial pressure power spectra, and carotid-cardiac baroreflex and Valsalva responses. After parabolic flight 1) 8 of 16 subjects could not tolerate 30 min of upright tilt (compared to 2 of 16 before flight); 2) 6 of 16 subjects vomited; 3) new intolerance to upright tilt was associated with exaggerated falls in total peripheral resistance, whereas vomiting was associated with increased R-wave-R-wave interval variability and carotid-cardiac baroreflex responsiveness; and 4) the proximate mode of new orthostatic failure differed in subjects who did and did not vomit, with vomiters experiencing comparatively isolated upright hypocapnia and cerebral vasoconstriction and nonvomiters experiencing signs and symptoms reminiscent of the clinical postural tachycardia syndrome. Results suggest, first, that syndromes of orthostatic intolerance resembling those developing after space flight can develop after a brief (i.e., 2-h) parabolic flight and, second, that recent vomiting can influence the results of tests of autonomic cardiovascular function commonly utilized in returning astronauts.

Original languageEnglish (US)
Pages (from-to)67-82
Number of pages16
JournalJournal of applied physiology
Volume90
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Autonomic
  • Hypergravity
  • Microgravity
  • Postural tachycardia syndrome
  • Space flight
  • Vomiting

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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