Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma

Joanne S. Colt, Nathaniel Rothman, Richard K. Severson, Patricia Hartge, James R Cerhan, Nilanjan Chatterjee, Wendy Cozen, Lindsay M. Morton, Anneclaire J. De Roos, Scott Davis, Stephen Chanock, Sophia S. Wang

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Abstract

Organochlorine exposure was linked to non-Hodgkin lymphoma (NHL) risk. To determine whether this relation is modified by immune gene variation, we genotyped 61 polymorphisms in 36 immune genes in 1172 NHL cases and 982 controls from the National Cancer Institute-Surveillance, Epidemiology, and End Results (NCI-SEER) study. We examined 3 exposures with elevated risk in this study: PCB180 (plasma, dust measurements), the toxic equivalency quotient (an integrated functional measure of several organochlorines) in plasma, and α-chlordane (dust measurements, self-reported termiticide use). Plasma (100 cases, 100 controls) and dust (682 cases, 513 controls) levels were treated as natural log-transformed continuous variables. Unconditional logistic regression was used to calculate ß coefficients and odds ratios, stratified by genotype. Associations between all 3 exposures and NHL risk were limited to the same genotypes for IFNG (C-1615T) TT and IL4 (5′-UTR, Ex1-168C>T) CC. Associations between PCB180 in plasma and dust and NHL risk were limited to the same genotypes for IL16 (3′-UTR, Ex22+871A>G) AA, IL8(T-251A) TT, and IL10 (A-1082G) AG/GG. This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL. (Blood. 2009;113:1899-1905)

Original languageEnglish (US)
Pages (from-to)1899-1905
Number of pages7
JournalBlood
Volume113
Issue number9
DOIs
StatePublished - Feb 26 2009

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Non-Hodgkin's Lymphoma
Genes
Dust
Plasmas
Genotype
Interleukin-16
Chlordan
Epidemiology
Poisons
5' Untranslated Regions
Level control
3' Untranslated Regions
Gene-Environment Interaction
Polymorphism
Interleukin-8
National Cancer Institute (U.S.)
Interleukin-4
Interleukin-10
Logistics
Blood

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Colt, J. S., Rothman, N., Severson, R. K., Hartge, P., Cerhan, J. R., Chatterjee, N., ... Wang, S. S. (2009). Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. Blood, 113(9), 1899-1905. https://doi.org/10.1182/blood-2008-04-153858

Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. / Colt, Joanne S.; Rothman, Nathaniel; Severson, Richard K.; Hartge, Patricia; Cerhan, James R; Chatterjee, Nilanjan; Cozen, Wendy; Morton, Lindsay M.; De Roos, Anneclaire J.; Davis, Scott; Chanock, Stephen; Wang, Sophia S.

In: Blood, Vol. 113, No. 9, 26.02.2009, p. 1899-1905.

Research output: Contribution to journalArticle

Colt, JS, Rothman, N, Severson, RK, Hartge, P, Cerhan, JR, Chatterjee, N, Cozen, W, Morton, LM, De Roos, AJ, Davis, S, Chanock, S & Wang, SS 2009, 'Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma', Blood, vol. 113, no. 9, pp. 1899-1905. https://doi.org/10.1182/blood-2008-04-153858
Colt JS, Rothman N, Severson RK, Hartge P, Cerhan JR, Chatterjee N et al. Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. Blood. 2009 Feb 26;113(9):1899-1905. https://doi.org/10.1182/blood-2008-04-153858
Colt, Joanne S. ; Rothman, Nathaniel ; Severson, Richard K. ; Hartge, Patricia ; Cerhan, James R ; Chatterjee, Nilanjan ; Cozen, Wendy ; Morton, Lindsay M. ; De Roos, Anneclaire J. ; Davis, Scott ; Chanock, Stephen ; Wang, Sophia S. / Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. In: Blood. 2009 ; Vol. 113, No. 9. pp. 1899-1905.
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