Optimization of vancomycin dosing in very low-birth-weight preterm neonates

Theresa Madigan, Christine B. Teng, Jena Koshaish, Kent R. Johnson, Kevin K. Graner, Ritu Banerjee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: To compare vancomycin serum trough concentrations and 24-hour area under the serum concentration-versus-time curve (AUC24) among very low-birth-weight (VLBW) premature infants before and after implementation of an institution-wide increase in neonatal vancomycin dosing.

STUDY DESIGN: We performed a retrospective analysis of vancomycin concentrations among preterm VLBW neonates before (2007-2010) and after (2010-2013) implementation of a new vancomycin dosing protocol consisting of increased vancomycin daily dose and frequency of administration.

RESULTS: Neonates weighing 

CONCLUSION: Increasing the vancomycin daily dose and dosing frequency led to an increase in vancomycin trough concentrations and AUC24, and a decrease in the proportion of undetectable (<5.0 µg/mL) troughs, without an increase in toxicity among VLBW premature neonates.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalAmerican Journal of Perinatology
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Very Low Birth Weight Infant
Vancomycin
Newborn Infant
Serum
Premature Infants

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Madigan, T., Teng, C. B., Koshaish, J., Johnson, K. R., Graner, K. K., & Banerjee, R. (2015). Optimization of vancomycin dosing in very low-birth-weight preterm neonates. American Journal of Perinatology, 32(1), 83-86. https://doi.org/10.1055/s-0034-1376183

Optimization of vancomycin dosing in very low-birth-weight preterm neonates. / Madigan, Theresa; Teng, Christine B.; Koshaish, Jena; Johnson, Kent R.; Graner, Kevin K.; Banerjee, Ritu.

In: American Journal of Perinatology, Vol. 32, No. 1, 01.01.2015, p. 83-86.

Research output: Contribution to journalArticle

Madigan, T, Teng, CB, Koshaish, J, Johnson, KR, Graner, KK & Banerjee, R 2015, 'Optimization of vancomycin dosing in very low-birth-weight preterm neonates', American Journal of Perinatology, vol. 32, no. 1, pp. 83-86. https://doi.org/10.1055/s-0034-1376183
Madigan, Theresa ; Teng, Christine B. ; Koshaish, Jena ; Johnson, Kent R. ; Graner, Kevin K. ; Banerjee, Ritu. / Optimization of vancomycin dosing in very low-birth-weight preterm neonates. In: American Journal of Perinatology. 2015 ; Vol. 32, No. 1. pp. 83-86.
@article{cf43aca900be4d46967247dda7cf7d19,
title = "Optimization of vancomycin dosing in very low-birth-weight preterm neonates",
abstract = "OBJECTIVE: To compare vancomycin serum trough concentrations and 24-hour area under the serum concentration-versus-time curve (AUC24) among very low-birth-weight (VLBW) premature infants before and after implementation of an institution-wide increase in neonatal vancomycin dosing.STUDY DESIGN: We performed a retrospective analysis of vancomycin concentrations among preterm VLBW neonates before (2007-2010) and after (2010-2013) implementation of a new vancomycin dosing protocol consisting of increased vancomycin daily dose and frequency of administration.RESULTS: Neonates weighing CONCLUSION: Increasing the vancomycin daily dose and dosing frequency led to an increase in vancomycin trough concentrations and AUC24, and a decrease in the proportion of undetectable (<5.0 µg/mL) troughs, without an increase in toxicity among VLBW premature neonates.",
author = "Theresa Madigan and Teng, {Christine B.} and Jena Koshaish and Johnson, {Kent R.} and Graner, {Kevin K.} and Ritu Banerjee",
year = "2015",
month = "1",
day = "1",
doi = "10.1055/s-0034-1376183",
language = "English (US)",
volume = "32",
pages = "83--86",
journal = "American Journal of Perinatology",
issn = "0735-1631",
publisher = "Thieme Medical Publishers",
number = "1",

}

TY - JOUR

T1 - Optimization of vancomycin dosing in very low-birth-weight preterm neonates

AU - Madigan, Theresa

AU - Teng, Christine B.

AU - Koshaish, Jena

AU - Johnson, Kent R.

AU - Graner, Kevin K.

AU - Banerjee, Ritu

PY - 2015/1/1

Y1 - 2015/1/1

N2 - OBJECTIVE: To compare vancomycin serum trough concentrations and 24-hour area under the serum concentration-versus-time curve (AUC24) among very low-birth-weight (VLBW) premature infants before and after implementation of an institution-wide increase in neonatal vancomycin dosing.STUDY DESIGN: We performed a retrospective analysis of vancomycin concentrations among preterm VLBW neonates before (2007-2010) and after (2010-2013) implementation of a new vancomycin dosing protocol consisting of increased vancomycin daily dose and frequency of administration.RESULTS: Neonates weighing CONCLUSION: Increasing the vancomycin daily dose and dosing frequency led to an increase in vancomycin trough concentrations and AUC24, and a decrease in the proportion of undetectable (<5.0 µg/mL) troughs, without an increase in toxicity among VLBW premature neonates.

AB - OBJECTIVE: To compare vancomycin serum trough concentrations and 24-hour area under the serum concentration-versus-time curve (AUC24) among very low-birth-weight (VLBW) premature infants before and after implementation of an institution-wide increase in neonatal vancomycin dosing.STUDY DESIGN: We performed a retrospective analysis of vancomycin concentrations among preterm VLBW neonates before (2007-2010) and after (2010-2013) implementation of a new vancomycin dosing protocol consisting of increased vancomycin daily dose and frequency of administration.RESULTS: Neonates weighing CONCLUSION: Increasing the vancomycin daily dose and dosing frequency led to an increase in vancomycin trough concentrations and AUC24, and a decrease in the proportion of undetectable (<5.0 µg/mL) troughs, without an increase in toxicity among VLBW premature neonates.

UR - http://www.scopus.com/inward/record.url?scp=84965123894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965123894&partnerID=8YFLogxK

U2 - 10.1055/s-0034-1376183

DO - 10.1055/s-0034-1376183

M3 - Article

VL - 32

SP - 83

EP - 86

JO - American Journal of Perinatology

JF - American Journal of Perinatology

SN - 0735-1631

IS - 1

ER -