Optimal treatment strategies for localized and advanced microsatellite instability-high colorectal cancer

Axel F Grothey

Research output: Contribution to journalArticle

Abstract

The defective mismatch repair phenotype (MMR-D) has been recognized as a distinct form of colorectal cancers with specific clinical and biologic features. It is caused by a lack of expression of mismatch repair enzymes in tumor cells either on the basis of hereditary or sporadic mutation of gene(s) encoding the enzymes such as in the Lynch syndrome, or by silencing of gene transcription due to promoter methylation. Colorectal cancers of the MMR-D phenotype have consistently shown to be associated with good prognosis and are likely, at least in early-stage disease, resistant to fluoropyrimidine monotherapy. These characteristics have significant implications for clinical practice and treatment strategies, particularly in the adjuvant setting.

Original languageEnglish (US)
Pages (from-to)36-41
Number of pages6
JournalCurrent Colorectal Cancer Reports
Volume8
Issue number1
DOIs
StatePublished - Mar 2012

Fingerprint

Microsatellite Instability
DNA Mismatch Repair
Colorectal Neoplasms
Phenotype
Hereditary Nonpolyposis Colorectal Neoplasms
Gene Silencing
Enzymes
Methylation
Mutation
Genes
Neoplasms

Keywords

  • Colon cancer
  • Fluoropyrimidine
  • Irinotecan
  • Microsatellite instability
  • Mismatch repair enzymes

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Hepatology

Cite this

Optimal treatment strategies for localized and advanced microsatellite instability-high colorectal cancer. / Grothey, Axel F.

In: Current Colorectal Cancer Reports, Vol. 8, No. 1, 03.2012, p. 36-41.

Research output: Contribution to journalArticle

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