Abstract
The defective mismatch repair phenotype (MMR-D) has been recognized as a distinct form of colorectal cancers with specific clinical and biologic features. It is caused by a lack of expression of mismatch repair enzymes in tumor cells either on the basis of hereditary or sporadic mutation of gene(s) encoding the enzymes such as in the Lynch syndrome, or by silencing of gene transcription due to promoter methylation. Colorectal cancers of the MMR-D phenotype have consistently shown to be associated with good prognosis and are likely, at least in early-stage disease, resistant to fluoropyrimidine monotherapy. These characteristics have significant implications for clinical practice and treatment strategies, particularly in the adjuvant setting.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 36-41 |
| Number of pages | 6 |
| Journal | Current Colorectal Cancer Reports |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2012 |
Fingerprint
Keywords
- Colon cancer
- Fluoropyrimidine
- Irinotecan
- Microsatellite instability
- Mismatch repair enzymes
ASJC Scopus subject areas
- Oncology
- Gastroenterology
- Hepatology
Cite this
Optimal treatment strategies for localized and advanced microsatellite instability-high colorectal cancer. / Grothey, Axel F.
In: Current Colorectal Cancer Reports, Vol. 8, No. 1, 03.2012, p. 36-41.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optimal treatment strategies for localized and advanced microsatellite instability-high colorectal cancer
AU - Grothey, Axel F
PY - 2012/3
Y1 - 2012/3
N2 - The defective mismatch repair phenotype (MMR-D) has been recognized as a distinct form of colorectal cancers with specific clinical and biologic features. It is caused by a lack of expression of mismatch repair enzymes in tumor cells either on the basis of hereditary or sporadic mutation of gene(s) encoding the enzymes such as in the Lynch syndrome, or by silencing of gene transcription due to promoter methylation. Colorectal cancers of the MMR-D phenotype have consistently shown to be associated with good prognosis and are likely, at least in early-stage disease, resistant to fluoropyrimidine monotherapy. These characteristics have significant implications for clinical practice and treatment strategies, particularly in the adjuvant setting.
AB - The defective mismatch repair phenotype (MMR-D) has been recognized as a distinct form of colorectal cancers with specific clinical and biologic features. It is caused by a lack of expression of mismatch repair enzymes in tumor cells either on the basis of hereditary or sporadic mutation of gene(s) encoding the enzymes such as in the Lynch syndrome, or by silencing of gene transcription due to promoter methylation. Colorectal cancers of the MMR-D phenotype have consistently shown to be associated with good prognosis and are likely, at least in early-stage disease, resistant to fluoropyrimidine monotherapy. These characteristics have significant implications for clinical practice and treatment strategies, particularly in the adjuvant setting.
KW - Colon cancer
KW - Fluoropyrimidine
KW - Irinotecan
KW - Microsatellite instability
KW - Mismatch repair enzymes
UR - http://www.scopus.com/inward/record.url?scp=84862764427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862764427&partnerID=8YFLogxK
U2 - 10.1007/s11888-011-0117-y
DO - 10.1007/s11888-011-0117-y
M3 - Article
AN - SCOPUS:84862764427
VL - 8
SP - 36
EP - 41
JO - Current Colorectal Cancer Reports
JF - Current Colorectal Cancer Reports
SN - 1556-3790
IS - 1
ER -