Onapristone suppresses prolactin production in explant cultures of leiomyoma

Douglas J. Austin; Romana A. Nowak; Elizabeth A. Stewart

doi:10.1159/000010120

Onapristone suppresses prolactin production in explant cultures of leiomyoma

Douglas J. Austin, Romana A. Nowak, Elizabeth A. Stewart

Obstetrics/Gynecology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: To assess the action of onapristone, a type I antiprogestin, on prolactin (PRL) production by explant cultures of leiomyoma and myometrium. Design: Explant cultures of myometrium and leiomyomas from 3 premenopausal women undergoing hysterectomy in the proliferative phase of the menstrual cycle. Main Outcome Measures: PRL secretion measured by radioimmunoassay. Results: PRL secretion was decreased in leiomyomas by onapristone. There was no effect in the myometrium. There was no additional effect with the addition of the type II antiprogestin mifepristone (RU 486). Conclusion: PRL production is suppressed in leiomyomas but not in myometrium after treatment with onapristone in vitro. This suppression may serve as a marker for the clinical effectiveness of agents used in the treatment of leiomyomas.

Original language	English (US)
Pages (from-to)	268-271
Number of pages	4
Journal	Gynecologic and Obstetric Investigation
Volume	47
Issue number	4
DOIs	https://doi.org/10.1159/000010120
State	Published - 1999

Keywords

Leiomyoma
Myometrium
Onapristone
Prolactin
Prolactin receptor

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

Access to Document

10.1159/000010120

Cite this

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title = "Onapristone suppresses prolactin production in explant cultures of leiomyoma",

abstract = "Objective: To assess the action of onapristone, a type I antiprogestin, on prolactin (PRL) production by explant cultures of leiomyoma and myometrium. Design: Explant cultures of myometrium and leiomyomas from 3 premenopausal women undergoing hysterectomy in the proliferative phase of the menstrual cycle. Main Outcome Measures: PRL secretion measured by radioimmunoassay. Results: PRL secretion was decreased in leiomyomas by onapristone. There was no effect in the myometrium. There was no additional effect with the addition of the type II antiprogestin mifepristone (RU 486). Conclusion: PRL production is suppressed in leiomyomas but not in myometrium after treatment with onapristone in vitro. This suppression may serve as a marker for the clinical effectiveness of agents used in the treatment of leiomyomas.",

keywords = "Leiomyoma, Myometrium, Onapristone, Prolactin, Prolactin receptor",

author = "Austin, {Douglas J.} and Nowak, {Romana A.} and Stewart, {Elizabeth A.}",

year = "1999",

doi = "10.1159/000010120",

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pages = "268--271",

journal = "Gynecologic and Obstetric Investigation",

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T1 - Onapristone suppresses prolactin production in explant cultures of leiomyoma

AU - Austin, Douglas J.

AU - Nowak, Romana A.

AU - Stewart, Elizabeth A.

PY - 1999

Y1 - 1999

N2 - Objective: To assess the action of onapristone, a type I antiprogestin, on prolactin (PRL) production by explant cultures of leiomyoma and myometrium. Design: Explant cultures of myometrium and leiomyomas from 3 premenopausal women undergoing hysterectomy in the proliferative phase of the menstrual cycle. Main Outcome Measures: PRL secretion measured by radioimmunoassay. Results: PRL secretion was decreased in leiomyomas by onapristone. There was no effect in the myometrium. There was no additional effect with the addition of the type II antiprogestin mifepristone (RU 486). Conclusion: PRL production is suppressed in leiomyomas but not in myometrium after treatment with onapristone in vitro. This suppression may serve as a marker for the clinical effectiveness of agents used in the treatment of leiomyomas.

AB - Objective: To assess the action of onapristone, a type I antiprogestin, on prolactin (PRL) production by explant cultures of leiomyoma and myometrium. Design: Explant cultures of myometrium and leiomyomas from 3 premenopausal women undergoing hysterectomy in the proliferative phase of the menstrual cycle. Main Outcome Measures: PRL secretion measured by radioimmunoassay. Results: PRL secretion was decreased in leiomyomas by onapristone. There was no effect in the myometrium. There was no additional effect with the addition of the type II antiprogestin mifepristone (RU 486). Conclusion: PRL production is suppressed in leiomyomas but not in myometrium after treatment with onapristone in vitro. This suppression may serve as a marker for the clinical effectiveness of agents used in the treatment of leiomyomas.

KW - Leiomyoma

KW - Myometrium

KW - Onapristone

KW - Prolactin

KW - Prolactin receptor

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Onapristone suppresses prolactin production in explant cultures of leiomyoma

Abstract

Keywords

ASJC Scopus subject areas

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