Onapristone suppresses prolactin production in explant cultures of leiomyoma

Douglas J. Austin, Romana A. Nowak, Elizabeth A Stewart

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To assess the action of onapristone, a type I antiprogestin, on prolactin (PRL) production by explant cultures of leiomyoma and myometrium. Design: Explant cultures of myometrium and leiomyomas from 3 premenopausal women undergoing hysterectomy in the proliferative phase of the menstrual cycle. Main Outcome Measures: PRL secretion measured by radioimmunoassay. Results: PRL secretion was decreased in leiomyomas by onapristone. There was no effect in the myometrium. There was no additional effect with the addition of the type II antiprogestin mifepristone (RU 486). Conclusion: PRL production is suppressed in leiomyomas but not in myometrium after treatment with onapristone in vitro. This suppression may serve as a marker for the clinical effectiveness of agents used in the treatment of leiomyomas.

Original languageEnglish (US)
Pages (from-to)268-271
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume47
Issue number4
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Leiomyoma
Prolactin
Myometrium
Mifepristone
Follicular Phase
Hysterectomy
Radioimmunoassay
Outcome Assessment (Health Care)
onapristone
Therapeutics

Keywords

  • Leiomyoma
  • Myometrium
  • Onapristone
  • Prolactin
  • Prolactin receptor

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Onapristone suppresses prolactin production in explant cultures of leiomyoma. / Austin, Douglas J.; Nowak, Romana A.; Stewart, Elizabeth A.

In: Gynecologic and Obstetric Investigation, Vol. 47, No. 4, 1999, p. 268-271.

Research output: Contribution to journalArticle

@article{fadef5cc4e2740d88d14d2ce2d55023c,
title = "Onapristone suppresses prolactin production in explant cultures of leiomyoma",
abstract = "Objective: To assess the action of onapristone, a type I antiprogestin, on prolactin (PRL) production by explant cultures of leiomyoma and myometrium. Design: Explant cultures of myometrium and leiomyomas from 3 premenopausal women undergoing hysterectomy in the proliferative phase of the menstrual cycle. Main Outcome Measures: PRL secretion measured by radioimmunoassay. Results: PRL secretion was decreased in leiomyomas by onapristone. There was no effect in the myometrium. There was no additional effect with the addition of the type II antiprogestin mifepristone (RU 486). Conclusion: PRL production is suppressed in leiomyomas but not in myometrium after treatment with onapristone in vitro. This suppression may serve as a marker for the clinical effectiveness of agents used in the treatment of leiomyomas.",
keywords = "Leiomyoma, Myometrium, Onapristone, Prolactin, Prolactin receptor",
author = "Austin, {Douglas J.} and Nowak, {Romana A.} and Stewart, {Elizabeth A}",
year = "1999",
doi = "10.1159/000010120",
language = "English (US)",
volume = "47",
pages = "268--271",
journal = "Gynecologic and Obstetric Investigation",
issn = "0378-7346",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Onapristone suppresses prolactin production in explant cultures of leiomyoma

AU - Austin, Douglas J.

AU - Nowak, Romana A.

AU - Stewart, Elizabeth A

PY - 1999

Y1 - 1999

N2 - Objective: To assess the action of onapristone, a type I antiprogestin, on prolactin (PRL) production by explant cultures of leiomyoma and myometrium. Design: Explant cultures of myometrium and leiomyomas from 3 premenopausal women undergoing hysterectomy in the proliferative phase of the menstrual cycle. Main Outcome Measures: PRL secretion measured by radioimmunoassay. Results: PRL secretion was decreased in leiomyomas by onapristone. There was no effect in the myometrium. There was no additional effect with the addition of the type II antiprogestin mifepristone (RU 486). Conclusion: PRL production is suppressed in leiomyomas but not in myometrium after treatment with onapristone in vitro. This suppression may serve as a marker for the clinical effectiveness of agents used in the treatment of leiomyomas.

AB - Objective: To assess the action of onapristone, a type I antiprogestin, on prolactin (PRL) production by explant cultures of leiomyoma and myometrium. Design: Explant cultures of myometrium and leiomyomas from 3 premenopausal women undergoing hysterectomy in the proliferative phase of the menstrual cycle. Main Outcome Measures: PRL secretion measured by radioimmunoassay. Results: PRL secretion was decreased in leiomyomas by onapristone. There was no effect in the myometrium. There was no additional effect with the addition of the type II antiprogestin mifepristone (RU 486). Conclusion: PRL production is suppressed in leiomyomas but not in myometrium after treatment with onapristone in vitro. This suppression may serve as a marker for the clinical effectiveness of agents used in the treatment of leiomyomas.

KW - Leiomyoma

KW - Myometrium

KW - Onapristone

KW - Prolactin

KW - Prolactin receptor

UR - http://www.scopus.com/inward/record.url?scp=0033016603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033016603&partnerID=8YFLogxK

U2 - 10.1159/000010120

DO - 10.1159/000010120

M3 - Article

C2 - 10352391

AN - SCOPUS:0033016603

VL - 47

SP - 268

EP - 271

JO - Gynecologic and Obstetric Investigation

JF - Gynecologic and Obstetric Investigation

SN - 0378-7346

IS - 4

ER -