On to the road to degradation: Atherosclerosis and the proteasome

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Protein metabolism is a central element of every living cell. The ubiquitin-proteasome system (UPS) is an integral part of the protein metabolism machinery mediating post-transcriptional processing and degradation of the majority of intracellular proteins. Over the past few years, remarkable progress has been made in our understanding of the role of the UPS in vascular biology and pathobiology, particularly atherosclerosis. This review reflects on the recent developments from the effects on endothelial cells and the initial stage of atherosclerosis to the effects on vascular smooth muscle and the progression stage of atherosclerosis and finally to the effects on cell viability and the complication stage of atherosclerosis. It will conclude with the integration of the available information in a synoptic view of the involvement of the UPS in atherosclerosis.

Original languageEnglish (US)
Pages (from-to)291-302
Number of pages12
JournalCardiovascular research
Volume85
Issue number2
DOIs
StatePublished - Jan 2010

Keywords

  • Atherosclerosis
  • Inflammation
  • Oxidative stress
  • Proteasome
  • Ubiquitin

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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