TY - JOUR
T1 - Oligodendroglial tumors
T2 - Diagnostic and molecular pathology
AU - Rodriguez, Fausto J.
AU - Giannini, Caterina
PY - 2010/5
Y1 - 2010/5
N2 - Oligodendroglial tumors, which encompass pure oligodendroglioma and mixed oligoastrocytoma, represent the second most common glioma in adults after glioblastoma. They remain controversial neoplasms in the realm of surgical neuropathology. The early recognition of their more favorable prognosis and responsiveness to treatment when compared with diffusely infiltrating astrocytomas has influenced the pathologic diagnostic interpretation, and resulted in a pervasive interobserver variability. The more recent finding of an increased frequency of 1p/19q deletion in these tumors by cytogenetic analysis, and the association of this molecular abnormality with a better prognosis has greatly impacted the field of neuro-oncology. In this review, we focus on important histopathologic aspects in the evaluation of oligodendroglial tumors, key differential diagnoses, and highlight particular clinical and molecular characteristics, as well as current diagnostic and conceptual controversies.
AB - Oligodendroglial tumors, which encompass pure oligodendroglioma and mixed oligoastrocytoma, represent the second most common glioma in adults after glioblastoma. They remain controversial neoplasms in the realm of surgical neuropathology. The early recognition of their more favorable prognosis and responsiveness to treatment when compared with diffusely infiltrating astrocytomas has influenced the pathologic diagnostic interpretation, and resulted in a pervasive interobserver variability. The more recent finding of an increased frequency of 1p/19q deletion in these tumors by cytogenetic analysis, and the association of this molecular abnormality with a better prognosis has greatly impacted the field of neuro-oncology. In this review, we focus on important histopathologic aspects in the evaluation of oligodendroglial tumors, key differential diagnoses, and highlight particular clinical and molecular characteristics, as well as current diagnostic and conceptual controversies.
KW - Brain tumor
KW - Grading
KW - Oligoastrocytoma
KW - Oligodendroglioma
UR - http://www.scopus.com/inward/record.url?scp=77955234721&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955234721&partnerID=8YFLogxK
U2 - 10.1053/j.semdp.2010.05.001
DO - 10.1053/j.semdp.2010.05.001
M3 - Article
C2 - 20860317
AN - SCOPUS:77955234721
SN - 0740-2570
VL - 27
SP - 136
EP - 145
JO - Seminars in Diagnostic Pathology
JF - Seminars in Diagnostic Pathology
IS - 2
ER -