TY - JOUR
T1 - Obstructive sleep apnea is associated with increased high-sensitivity cardiac troponin T levels
AU - Randby, Anna
AU - Namtvedt, Silje K.
AU - Einvik, Gunnar
AU - Hrubos-Strmø, Harald
AU - Hagve, Tor Arne
AU - Somers, Virend K.
AU - Omland, Torbjrøn
N1 - Funding Information:
Financial/nonfinancial disclosures: The authors have reported to CHEST the following conflicts of interest: Dr Somers has served as a consultant for ResMed; Sova Pharmaceuticals, Inc; Apnex Medical, Inc; Johnson & Johnson; Merck & Co, Inc; and Respircardia, Inc (Cardiac Concepts). He has received research grants from the Philips Respironics Sleep and Breathing Foundation, ELA Medical, and Select Research, Inc. Dr Omland has received research support and speaker's honoraria from Roche Diagnostics and Abbott Laboratories. Drs Randby, Namtvedt, Einvik, Hrubos-Strøm, and Hagve have reported that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Funding Information:
Funding/Support: This work was supported by the South-Eastern Norway Regional Health Authority [ Grants 2004219, 2007048 ] and the University of Oslo, Oslo, Norway.
PY - 2012/9
Y1 - 2012/9
N2 - Background: Obstructive sleep apnea (OSA) is associated with increased cardiovascular risk. Stress imposed on the myocardium by repeated severe hypoxemia and/or BP surges during sleep may result in subclinical myocardial injury. A high-sensitivity cardiac troponin T (hs-cTnT) assay has been developed. We hypothesized that the severity of OSA, as assessed by the apnea-hypopnea index (AHI), is associated with circulating levels of hs-cTnT in the general population. Methods: Five hundred five subjects drawn from the general population (age range, 30-65 years; 45% women) underwent in-hospital polysomnography and had morning blood samples drawn. Oversampling of subjects at high risk of OSA was performed. Results: Overall, hs-cTnT was detectable (≥3 ng/L) in 216 subjects (42.8%). After categorizing subjects according to AHI cutoffs that correspond to no, mild to moderate, and severe OSA, the proportion of subjects with detectable hs-cTnT levels increased with increasing severity of OSA (P for trend <.001). Multivariate logistic regression with detectable hs-cTnT as the dependent variable was used to further assess the association between OSA and troponin T. After adjustment for significant univariate predictors of detectable hs-cTnT, the association between AHI and hs-cTnT was no longer statistically significant. Conclusions: The prevalence of detectable hs-cTnT increases in proportion to OSA severity, but this association is likely to be caused by a clustering of cardiovascular risk factors among subjects with OSA.
AB - Background: Obstructive sleep apnea (OSA) is associated with increased cardiovascular risk. Stress imposed on the myocardium by repeated severe hypoxemia and/or BP surges during sleep may result in subclinical myocardial injury. A high-sensitivity cardiac troponin T (hs-cTnT) assay has been developed. We hypothesized that the severity of OSA, as assessed by the apnea-hypopnea index (AHI), is associated with circulating levels of hs-cTnT in the general population. Methods: Five hundred five subjects drawn from the general population (age range, 30-65 years; 45% women) underwent in-hospital polysomnography and had morning blood samples drawn. Oversampling of subjects at high risk of OSA was performed. Results: Overall, hs-cTnT was detectable (≥3 ng/L) in 216 subjects (42.8%). After categorizing subjects according to AHI cutoffs that correspond to no, mild to moderate, and severe OSA, the proportion of subjects with detectable hs-cTnT levels increased with increasing severity of OSA (P for trend <.001). Multivariate logistic regression with detectable hs-cTnT as the dependent variable was used to further assess the association between OSA and troponin T. After adjustment for significant univariate predictors of detectable hs-cTnT, the association between AHI and hs-cTnT was no longer statistically significant. Conclusions: The prevalence of detectable hs-cTnT increases in proportion to OSA severity, but this association is likely to be caused by a clustering of cardiovascular risk factors among subjects with OSA.
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U2 - 10.1378/chest.11-1779
DO - 10.1378/chest.11-1779
M3 - Article
C2 - 22406957
AN - SCOPUS:84865845866
SN - 0012-3692
VL - 142
SP - 639
EP - 646
JO - Chest
JF - Chest
IS - 3
ER -