Obstructive sleep apnea is a risk factor for barrett's esophagus

Cadman Leggett, Emmanuel C. Gorospe, Andrew D. Calvin, William S. Harmsen, Alan R. Zinsmeister, Sean Caples, Virend Somers, Kelly Dunagan, Lori Lutzke, Kenneth Ke Ning Wang, Prasad G Iyer

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background & Aims: Common risk factors for obstructive sleep apnea (OSA) and Barrett's esophagus (BE) include obesity and gastroesophageal reflux disease (GERD). The aims of this study were to assess the association between OSA and BE and to determine whether the association is independent of GERD and body mass index (BMI). Methods: Patients who had undergone a diagnostic polysomnogram and esophagogastroduodenoscopy were identified by using Mayo Clinic (Rochester, Minnesota) databases from January 2000-November 2011. They were randomly matched for age, sex, and BMI at time of polysomnogram into the following groups: BE but no OSA (n= 36), OSA but no BE (n= 78), both (n= 74), or neither (n= 74). Clinical and demographic variables were abstracted from medical records. The association between OSA and BE was assessed by using a multiple variable logistic model that incorporated age, sex, BMI, clinical diagnosis of GERD, and smoking history. Results: Subjects with OSA had an 80% increased risk for BE compared with subjects without OSA (odds ratio, 1.8; 95% confidence interval, 1.1-3.2; P= .03). These findings were independent of age, sex, BMI, GERD, and smoking history. Increasing severity of OSA, measured by using the apnea-hypopnea index, was associated with an increased risk of BE (odds ratio, 1.2 per 10-unit increase in apnea-hypopnea index; 95% confidence interval, 1.0-1.3; P= .03). Conclusions: In this case-control study, OSA was associated with an increased risk of BE, potentially through BMI and GERD independent mechanisms. Patients with OSA may benefit from evaluation for BE.

Original languageEnglish (US)
JournalClinical Gastroenterology and Hepatology
Volume12
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Barrett Esophagus
Obstructive Sleep Apnea
Gastroesophageal Reflux
Body Mass Index
Apnea
Smoking
History
Odds Ratio
Confidence Intervals
Digestive System Endoscopy
Medical Records
Case-Control Studies
Obesity
Logistic Models
Demography
Databases

Keywords

  • Esophageal adenocarcinoma
  • Obesity
  • Screening
  • Sleep-related breathing disorder

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Obstructive sleep apnea is a risk factor for barrett's esophagus. / Leggett, Cadman; Gorospe, Emmanuel C.; Calvin, Andrew D.; Harmsen, William S.; Zinsmeister, Alan R.; Caples, Sean; Somers, Virend; Dunagan, Kelly; Lutzke, Lori; Wang, Kenneth Ke Ning; Iyer, Prasad G.

In: Clinical Gastroenterology and Hepatology, Vol. 12, No. 4, 2014.

Research output: Contribution to journalArticle

Leggett, Cadman ; Gorospe, Emmanuel C. ; Calvin, Andrew D. ; Harmsen, William S. ; Zinsmeister, Alan R. ; Caples, Sean ; Somers, Virend ; Dunagan, Kelly ; Lutzke, Lori ; Wang, Kenneth Ke Ning ; Iyer, Prasad G. / Obstructive sleep apnea is a risk factor for barrett's esophagus. In: Clinical Gastroenterology and Hepatology. 2014 ; Vol. 12, No. 4.
@article{f7341cdd251d4e16a1f521ab1cfd1cdb,
title = "Obstructive sleep apnea is a risk factor for barrett's esophagus",
abstract = "Background & Aims: Common risk factors for obstructive sleep apnea (OSA) and Barrett's esophagus (BE) include obesity and gastroesophageal reflux disease (GERD). The aims of this study were to assess the association between OSA and BE and to determine whether the association is independent of GERD and body mass index (BMI). Methods: Patients who had undergone a diagnostic polysomnogram and esophagogastroduodenoscopy were identified by using Mayo Clinic (Rochester, Minnesota) databases from January 2000-November 2011. They were randomly matched for age, sex, and BMI at time of polysomnogram into the following groups: BE but no OSA (n= 36), OSA but no BE (n= 78), both (n= 74), or neither (n= 74). Clinical and demographic variables were abstracted from medical records. The association between OSA and BE was assessed by using a multiple variable logistic model that incorporated age, sex, BMI, clinical diagnosis of GERD, and smoking history. Results: Subjects with OSA had an 80{\%} increased risk for BE compared with subjects without OSA (odds ratio, 1.8; 95{\%} confidence interval, 1.1-3.2; P= .03). These findings were independent of age, sex, BMI, GERD, and smoking history. Increasing severity of OSA, measured by using the apnea-hypopnea index, was associated with an increased risk of BE (odds ratio, 1.2 per 10-unit increase in apnea-hypopnea index; 95{\%} confidence interval, 1.0-1.3; P= .03). Conclusions: In this case-control study, OSA was associated with an increased risk of BE, potentially through BMI and GERD independent mechanisms. Patients with OSA may benefit from evaluation for BE.",
keywords = "Esophageal adenocarcinoma, Obesity, Screening, Sleep-related breathing disorder",
author = "Cadman Leggett and Gorospe, {Emmanuel C.} and Calvin, {Andrew D.} and Harmsen, {William S.} and Zinsmeister, {Alan R.} and Sean Caples and Virend Somers and Kelly Dunagan and Lori Lutzke and Wang, {Kenneth Ke Ning} and Iyer, {Prasad G}",
year = "2014",
doi = "10.1016/j.cgh.2013.08.043",
language = "English (US)",
volume = "12",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Obstructive sleep apnea is a risk factor for barrett's esophagus

AU - Leggett, Cadman

AU - Gorospe, Emmanuel C.

AU - Calvin, Andrew D.

AU - Harmsen, William S.

AU - Zinsmeister, Alan R.

AU - Caples, Sean

AU - Somers, Virend

AU - Dunagan, Kelly

AU - Lutzke, Lori

AU - Wang, Kenneth Ke Ning

AU - Iyer, Prasad G

PY - 2014

Y1 - 2014

N2 - Background & Aims: Common risk factors for obstructive sleep apnea (OSA) and Barrett's esophagus (BE) include obesity and gastroesophageal reflux disease (GERD). The aims of this study were to assess the association between OSA and BE and to determine whether the association is independent of GERD and body mass index (BMI). Methods: Patients who had undergone a diagnostic polysomnogram and esophagogastroduodenoscopy were identified by using Mayo Clinic (Rochester, Minnesota) databases from January 2000-November 2011. They were randomly matched for age, sex, and BMI at time of polysomnogram into the following groups: BE but no OSA (n= 36), OSA but no BE (n= 78), both (n= 74), or neither (n= 74). Clinical and demographic variables were abstracted from medical records. The association between OSA and BE was assessed by using a multiple variable logistic model that incorporated age, sex, BMI, clinical diagnosis of GERD, and smoking history. Results: Subjects with OSA had an 80% increased risk for BE compared with subjects without OSA (odds ratio, 1.8; 95% confidence interval, 1.1-3.2; P= .03). These findings were independent of age, sex, BMI, GERD, and smoking history. Increasing severity of OSA, measured by using the apnea-hypopnea index, was associated with an increased risk of BE (odds ratio, 1.2 per 10-unit increase in apnea-hypopnea index; 95% confidence interval, 1.0-1.3; P= .03). Conclusions: In this case-control study, OSA was associated with an increased risk of BE, potentially through BMI and GERD independent mechanisms. Patients with OSA may benefit from evaluation for BE.

AB - Background & Aims: Common risk factors for obstructive sleep apnea (OSA) and Barrett's esophagus (BE) include obesity and gastroesophageal reflux disease (GERD). The aims of this study were to assess the association between OSA and BE and to determine whether the association is independent of GERD and body mass index (BMI). Methods: Patients who had undergone a diagnostic polysomnogram and esophagogastroduodenoscopy were identified by using Mayo Clinic (Rochester, Minnesota) databases from January 2000-November 2011. They were randomly matched for age, sex, and BMI at time of polysomnogram into the following groups: BE but no OSA (n= 36), OSA but no BE (n= 78), both (n= 74), or neither (n= 74). Clinical and demographic variables were abstracted from medical records. The association between OSA and BE was assessed by using a multiple variable logistic model that incorporated age, sex, BMI, clinical diagnosis of GERD, and smoking history. Results: Subjects with OSA had an 80% increased risk for BE compared with subjects without OSA (odds ratio, 1.8; 95% confidence interval, 1.1-3.2; P= .03). These findings were independent of age, sex, BMI, GERD, and smoking history. Increasing severity of OSA, measured by using the apnea-hypopnea index, was associated with an increased risk of BE (odds ratio, 1.2 per 10-unit increase in apnea-hypopnea index; 95% confidence interval, 1.0-1.3; P= .03). Conclusions: In this case-control study, OSA was associated with an increased risk of BE, potentially through BMI and GERD independent mechanisms. Patients with OSA may benefit from evaluation for BE.

KW - Esophageal adenocarcinoma

KW - Obesity

KW - Screening

KW - Sleep-related breathing disorder

UR - http://www.scopus.com/inward/record.url?scp=84896087349&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896087349&partnerID=8YFLogxK

U2 - 10.1016/j.cgh.2013.08.043

DO - 10.1016/j.cgh.2013.08.043

M3 - Article

VL - 12

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

IS - 4

ER -