TY - JOUR
T1 - Obstructive sleep apnea is a risk factor for barrett's esophagus
AU - Leggett, Cadman L.
AU - Gorospe, Emmanuel C.
AU - Calvin, Andrew D.
AU - Harmsen, William S.
AU - Zinsmeister, Alan R.
AU - Caples, Sean
AU - Somers, Virend K.
AU - Dunagan, Kelly
AU - Lutzke, Lori
AU - Wang, Kenneth K.
AU - Iyer, Prasad G.
N1 - Funding Information:
Funding Supported in part by the American College of Gastroenterology, National Institutes of Diabetes, Digestive and Kidney Disease (grant RC4DK090413 ), and the Edward C. Rosenow Endowed Professorship Internal Medicine Residency Award.
PY - 2014/4
Y1 - 2014/4
N2 - Background & Aims: Common risk factors for obstructive sleep apnea (OSA) and Barrett's esophagus (BE) include obesity and gastroesophageal reflux disease (GERD). The aims of this study were to assess the association between OSA and BE and to determine whether the association is independent of GERD and body mass index (BMI). Methods: Patients who had undergone a diagnostic polysomnogram and esophagogastroduodenoscopy were identified by using Mayo Clinic (Rochester, Minnesota) databases from January 2000-November 2011. They were randomly matched for age, sex, and BMI at time of polysomnogram into the following groups: BE but no OSA (n= 36), OSA but no BE (n= 78), both (n= 74), or neither (n= 74). Clinical and demographic variables were abstracted from medical records. The association between OSA and BE was assessed by using a multiple variable logistic model that incorporated age, sex, BMI, clinical diagnosis of GERD, and smoking history. Results: Subjects with OSA had an 80% increased risk for BE compared with subjects without OSA (odds ratio, 1.8; 95% confidence interval, 1.1-3.2; P= .03). These findings were independent of age, sex, BMI, GERD, and smoking history. Increasing severity of OSA, measured by using the apnea-hypopnea index, was associated with an increased risk of BE (odds ratio, 1.2 per 10-unit increase in apnea-hypopnea index; 95% confidence interval, 1.0-1.3; P= .03). Conclusions: In this case-control study, OSA was associated with an increased risk of BE, potentially through BMI and GERD independent mechanisms. Patients with OSA may benefit from evaluation for BE.
AB - Background & Aims: Common risk factors for obstructive sleep apnea (OSA) and Barrett's esophagus (BE) include obesity and gastroesophageal reflux disease (GERD). The aims of this study were to assess the association between OSA and BE and to determine whether the association is independent of GERD and body mass index (BMI). Methods: Patients who had undergone a diagnostic polysomnogram and esophagogastroduodenoscopy were identified by using Mayo Clinic (Rochester, Minnesota) databases from January 2000-November 2011. They were randomly matched for age, sex, and BMI at time of polysomnogram into the following groups: BE but no OSA (n= 36), OSA but no BE (n= 78), both (n= 74), or neither (n= 74). Clinical and demographic variables were abstracted from medical records. The association between OSA and BE was assessed by using a multiple variable logistic model that incorporated age, sex, BMI, clinical diagnosis of GERD, and smoking history. Results: Subjects with OSA had an 80% increased risk for BE compared with subjects without OSA (odds ratio, 1.8; 95% confidence interval, 1.1-3.2; P= .03). These findings were independent of age, sex, BMI, GERD, and smoking history. Increasing severity of OSA, measured by using the apnea-hypopnea index, was associated with an increased risk of BE (odds ratio, 1.2 per 10-unit increase in apnea-hypopnea index; 95% confidence interval, 1.0-1.3; P= .03). Conclusions: In this case-control study, OSA was associated with an increased risk of BE, potentially through BMI and GERD independent mechanisms. Patients with OSA may benefit from evaluation for BE.
KW - Esophageal adenocarcinoma
KW - Obesity
KW - Screening
KW - Sleep-related breathing disorder
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U2 - 10.1016/j.cgh.2013.08.043
DO - 10.1016/j.cgh.2013.08.043
M3 - Article
C2 - 24035775
AN - SCOPUS:84896087349
SN - 1542-3565
VL - 12
SP - 583-588.e1
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 4
ER -